Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the  receptor protein of CRL2Prame complex

Protein neddylation and its alterations in human cancers for targeted therapy

(2018) Lisha Zhou et al.   CELLULAR SIGNALLING

Primary Cervical Malignant Melanoma

(2018) Can Yin et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Firmiana: towards a one-stop proteomic cloud platform for data processing and analysis

(2017) Jinwen Feng et al.   NATURE BIOTECHNOLOGY

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

(2016) Weijia Cai et al.   Cell Division

S6 Kinase- and β-TrCP2-Dependent Degradation of p19ArfIs Required for Cell Proliferation

(2015) Tadashi Nakagawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex

(2015) Henry C. Nguyen et al.   STRUCTURE

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

ARF tumor suppression in the nucleolus

(2014) Leonard B. Maggi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

(2014) Junfeng Xu et al.   MOLECULAR & CELLULAR PROTEOMICS

Loss ofCDKN2Aexpression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

(2014) Richard J. Young et al.   Pigment Cell & Melanoma Research

PRAME-Induced Inhibition of Retinoic Acid Receptor Signaling-Mediated Differentiation--A Possible Target for ATRA Response in AML without t(15;17)

(2013) L. Bullinger et al.   CLINICAL CANCER RESEARCH

Cullin-RING Ligases as Attractive Anti-cancer Targets

(2013) Yongchao Zhao et al.   CURRENT PHARMACEUTICAL DESIGN

Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression

(2013) Delin Chen et al.   MOLECULAR CELL

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

The cancer testis antigen PRAME as a biomarker for solid tumor cancer management

(2012) Steve Goodison et al.   Biomarkers in Medicine

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

Targeting neddylation in cancer therapy

(2012) Kristal Duncan et al.   Future Oncology

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters

(2011) Adalberto Costessi et al.   EMBO JOURNAL

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer

(2011) Meng Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study

(2011) Robert Pirker et al.   LANCET ONCOLOGY

ARF Suppresses Tumor Angiogenesis through Translational Control of VEGFA mRNA

(2010) Hiroyuki Kawagishi et al.   CANCER RESEARCH

The ARF tumor suppressor: Structure, functions and status in cancer

(2010) Peggy Ozenne et al.   INTERNATIONAL JOURNAL OF CANCER

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

(2010) Frances Wadelin et al.   Molecular Cancer

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence

(2009) L. Jia et al.   CANCER RESEARCH

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxygen-Regulated  2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL

(2009) L. Xie et al.   Science Signaling

RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival

(2009) Lijun Jia et al.   Cell Division

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL