期刊
INTERNATIONAL JOURNAL OF CANCER
卷 127, 期 10, 页码 2239-2247出版社
WILEY
DOI: 10.1002/ijc.25511
关键词
ARF; tumor suppressor; gene; p53; DNA damage; human tumor
类别
资金
- Ligue Nationale contre le Cancer
- Conseil Scientifique National d'AGIR a dom, INCa
- Association for Cancer Research (ARC), French Ministry of Education and Research
The INK4b-ARF-INK4a locus encodes two members of the INK4 family of cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a), and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing evidence that ARF signaling is complex, and involves p53-dependent or -independent pathways aiming mainly at restraining abnormal cell growth and at maintaining genomic stability. As such, ARF is a critical component of tumor surveillance, and its expression is decreased in human tumors. In this review, we present the current knowledge on ARF regulation and major functions. The ARF status in human tumors is also briefly summarized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据