Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis

(2020) Bing Zhai et al.   NATURE MEDICINE

Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

(2020) Irina Leonardi et al.   Cell Host & Microbe

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

Systemic anti-commensal response to fungi analyzed by flow cytometry is related to gut mycobiome ecology

(2020) Alicia Moreno-Sabater et al.   Microbiome

Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models

(2019) Jose J. Limon et al.   Cell Host & Microbe

Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses

(2019) Tzu-Yu Shao et al.   Cell Host & Microbe

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection

(2019) Jessica N. Witchley et al.   Cell Host & Microbe

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

(2019) Shen-Huan Liang et al.   Cell Host & Microbe

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

(2019) Petra Bacher et al.   CELL

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

(2019) Christopher S. Smillie et al.   CELL

Profound mycobiome differences between segregated mouse colonies do not influence Th17 responses to a newly introduced gut fungal commensal

(2019) Itai Doron et al.   FUNGAL GENETICS AND BIOLOGY

Gut Mycobiota in Immunity and Inflammatory Disease

(2019) Xin V. Li et al.   IMMUNITY

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

(2019) Eduard Ansaldo et al.   SCIENCE

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

(2019) Sohn G. Kim et al.   NATURE

A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis—A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial

(2018) John E Edwards et al.   CLINICAL INFECTIOUS DISEASES

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses

(2018) Gaetan Barbet et al.   IMMUNITY

CX3CR1+Macrophages and CD8+T Cells Control Intestinal IgA Production

(2018) Young-In Kim et al.   JOURNAL OF IMMUNOLOGY

CX3CR1+mononuclear phagocytes control immunity to intestinal fungi

(2018) Irina Leonardi et al.   SCIENCE

Inherited CARD9 Deficiency: Invasive Disease Caused by Ascomycete Fungi in Previously Healthy Children and Adults

(2018) Emilie Corvilain et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Response to Fungal Dysbiosis by Gut-Resident CX3CR1+ Mononuclear Phagocytes Aggravates Allergic Airway Disease

(2018) Xin Li et al.   Cell Host & Microbe

Synergistic convergence of microbiota-specific systemic IgG and secretory IgA

(2018) Jehane Fadlallah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Candida auris Outbreak and Its Control in an Intensive Care Setting

(2018) David W. Eyre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Experimental evolution of a fungal pathogen into a gut symbiont

(2018) Gloria Hoi Wan Tso et al.   SCIENCE

Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

(2018) Fiona M. Rudkin et al.   Nature Communications

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin

(2018) Adriana Flores-Langarica et al.   Frontiers in Immunology

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production

(2017) H Takaki et al.   Mucosal Immunology

The gut mycobiome of the Human Microbiome Project healthy cohort

(2017) Andrea K. Nash et al.   Microbiome

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Fungal microbiota dysbiosis in IBD

(2016) Harry Sokol et al.   GUT

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens

(2016) Melody Y. Zeng et al.   IMMUNITY

Serum Antibody Profile during Colonization of the Mouse Gut by Candida albicans: Relevance for Protection during Systemic Infection

(2016) Blanca Huertas et al.   JOURNAL OF PROTEOME RESEARCH

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Human seroreactivity to gut microbiota antigens

(2015) Benjamin S. Christmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic errors of the human caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity

(2015) Rebeca Pérez de Diego et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mycobiome: Approaches to analysis of intestinal fungi

(2015) Jie Tang et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

(2015) Di Fan et al.   NATURE MEDICINE

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

(2015) Andrew L. Kau et al.   Science Translational Medicine

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

(2015) Rebecca A. Drummond et al.   PLoS Pathogens

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Mendelian Genetics of Human Susceptibility to Fungal Infection

(2014) M. S. Lionakis et al.   Cold Spring Harbor Perspectives in Medicine

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Adaptive Immunity to Fungi

(2012) Marcel Wüthrich et al.   Annual Review of Immunology

FungiQuant: A broad-coverage fungal quantitative real-time PCR assay

(2012) Cindy M Liu et al.   BMC MICROBIOLOGY

Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases

(2012) Arturo Casadevall et al.   Cell Host & Microbe

Emerging fungal threats to animal, plant and ecosystem health

(2012) Matthew C. Fisher et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

(2012) T. W. Hand et al.   SCIENCE

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism

(2010) Erin E. McClelland et al.   JOURNAL OF CLINICAL INVESTIGATION

Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungusPneumocystis murina

(2010) Rekha R. Rapaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global Warming Will Bring New Fungal Diseases for Mammals

(2010) M. A. Garcia-Solache et al.   mBio

Candida albicans Colonization and ASCA in Familial Crohn's Disease

(2009) Annie Standaert-Vitse et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination

(2008) Andrew Y. Koh et al.   PLoS Pathogens

Anti-β-glucan antibodies in healthy human subjects

(2008) P. Chiani et al.   VACCINE