Inherited CARD9 Deficiency: Invasive Disease Caused by Ascomycete Fungi in Previously Healthy Children and Adults

A young girl with severe cerebral fungal infection due to card 9 deficiency

(2018) Pinar Gur Cetinkaya et al.   CLINICAL IMMUNOLOGY

GM-CSF therapy in human caspase recruitment domain–containing protein 9 deficiency

(2018) Rebecca A. Drummond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

(2018) Xiaowen Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human genetics of infectious diseases: Unique insights into immunological redundancy

(2018) Jean-Laurent Casanova et al.   SEMINARS IN IMMUNOLOGY

Dermatophytic disease with deficit in CARD9: A new case with a brain impairment

(2017) O. Boudghene Stambouli et al.   JOURNAL DE MYCOLOGIE MEDICALE

Allogeneic Reduced-Intensity Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: a Single-Center Prospective Trial

(2017) Mark Parta et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Risk Factors and Outcomes of Invasive Fungal Infections in Allogeneic Hematopoietic Cell Transplant Recipients

(2017) Marisa H. Miceli et al.   MYCOPATHOLOGIA

Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review

(2017) Kate E. Oberlin et al.   Transplant Infectious Disease

Cellular and Molecular Defects Underlying Invasive Fungal Infections—Revelations from Endemic Mycoses

(2017) Pamela P. Lee et al.   Frontiers in Immunology

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

(2016) J. Toubiana et al.   BLOOD

Dermatophyte abscesses caused by Trichophyton rubrum in a patient without pre-existing superficial dermatophytosis: a case report

(2016) Si-Hyun Kim et al.   BMC INFECTIOUS DISEASES

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Candidemia and invasive candidiasis in adults: A narrative review

(2016) Spinello Antinori et al.   European Journal of Internal Medicine

Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection

(2016) Chiung-Yu Hung et al.   INFECTION AND IMMUNITY

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

(2016) Christina Gavino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exome and genome sequencing for inborn errors of immunity

(2016) Isabelle Meyts et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic and Invasive Fungal Infections in a Family with CARD9 Deficiency

(2016) Ana Karina Alves de Medeiros et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Recent Advances in DOCK8 Immunodeficiency Syndrome

(2016) Qian Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Hyper IgM Syndrome: a Report from the USIDNET Registry

(2016) Emily A. Leven et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Superficial Phaeohyphomycosis Caused by Aureobasidium melanogenum Mimicking Tinea Nigra in an Immunocompetent Patient and Review of Published Reports

(2016) Wan-Ting Chen et al.   MYCOPATHOLOGIA

Impairment of Immune Response against Dematiaceous Fungi in Card9 Knockout Mice

(2016) Weiwei Wu et al.   MYCOPATHOLOGIA

The Changing Face of Dermatophytic Infections Worldwide

(2016) Ping Zhan et al.   MYCOPATHOLOGIA

The mutation significance cutoff: gene-level thresholds for variant predictions

(2016) Yuval Itan et al.   NATURE METHODS

Successful Granulocyte Colony-stimulating Factor Treatment of Relapsing Candida albicans Meningoencephalitis Caused by CARD9 Deficiency

(2016) Fatih Celmeli et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

(2016) Susanne Roth et al.   Cell Reports

Primary immune deficiencies with defects in neutrophil function

(2016) M. C. Dinauer   Hematology-American Society of Hematology Education Program

Ecology of aspergillosis: insights into the pathogenic potency ofAspergillus fumigatusand some otherAspergillusspecies

(2016) Caroline Paulussen et al.   Microbial Biotechnology

CARD9mutation linked toCorynespora cassiicolainfection in a Chinese patient

(2015) X.X. Yan et al.   BRITISH JOURNAL OF DERMATOLOGY

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Homozygous CARD9 Mutation in a Brazilian Patient with Deep Dermatophytosis

(2015) Anete S. Grumach et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

(2015) Yun Ling et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17–Mediated Immunity to the Opportunistic Fungal PathogenCandida albicans

(2015) Heather R. Conti et al.   JOURNAL OF IMMUNOLOGY

Delinking CARD9 and IL-17: CARD9 Protects againstCandida tropicalisInfection through a TNF-α–Dependent, IL-17–Independent Mechanism

(2015) Natasha Whibley et al.   JOURNAL OF IMMUNOLOGY

A new species of the oligotrophic genus Ochroconis (Sympoventuriaceae)

(2015) K. Samerpitak et al.   MYCOLOGICAL PROGRESS

CARD9 Deficiencies Linked to Impaired Neutrophil Functions Against Phialophora verrucosa

(2015) Pin Liang et al.   MYCOPATHOLOGIA

Case of dermatophyte abscess caused byTrichophyton rubrum: a case report and review of the literature

(2015) Makoto Inaoki et al.   MYCOSES

Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X)

(2015) Martin Herbst et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The human gene damage index as a gene-level approach to prioritizing exome variants

(2015) Yuval Itan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity

(2015) Takayuki Uematsu et al.   Scientific Reports

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

(2015) Anupam Jhingran et al.   PLoS Pathogens

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

(2015) Rebecca A. Drummond et al.   PLoS Pathogens

Posaconazole Treatment of Extensive Skin and Nail Dermatophytosis Due to Autosomal Recessive Deficiency of CARD9

(2015) Marie Jachiet et al.   JAMA Dermatology

Clinical, epidemiological, and therapeutic profile of dermatophytosis

(2014) Carla Andréa Avelar Pires et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

(2014) R. P. Gazendam et al.   BLOOD

CARD9 Deficiency and Spontaneous Central Nervous System Candidiasis: Complete Clinical Remission With GM-CSF Therapy

(2014) C. Gavino et al.   CLINICAL INFECTIOUS DISEASES

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi

(2014) A. Chowdhary et al.   CLINICAL MICROBIOLOGY AND INFECTION

Black Yeasts and Their Filamentous Relatives: Principles of Pathogenesis and Host Defense

(2014) S. Seyedmousavi et al.   CLINICAL MICROBIOLOGY REVIEWS

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

(2014) Rhiannon Parkhouse et al.   FEBS LETTERS

Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans

(2014) Hideki Yamamoto et al.   INFECTION AND IMMUNITY

Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity

(2014) Juan Manuel Torres et al.   JOURNAL OF CLINICAL INVESTIGATION

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

(2014) Xin-Ming Jia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Inherited CARD9 Deficiency in 2 Unrelated Patients With Invasive Exophiala Infection

(2014) Fanny Lanternier et al.   JOURNAL OF INFECTIOUS DISEASES

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

(2014) Jacinta Bustamante et al.   SEMINARS IN IMMUNOLOGY

Allogeneic Hematopoietic Cell Transplantation for GATA2 Deficiency in a Patient With Disseminated Human Papillomavirus Disease

(2014) Markus Maeurer et al.   TRANSPLANTATION

Black Molds and Melanized Yeasts Pathogenic to Humans

(2014) Anuradha Chowdhary et al.   Cold Spring Harbor Perspectives in Medicine

The Spectrum of Fungi That Infects Humans

(2014) J. R. Kohler et al.   Cold Spring Harbor Perspectives in Medicine

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity

(2013) M. A. Spinner et al.   BLOOD

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

(2013) Le-Le Zhu et al.   IMMUNITY

An ACT1 Mutation Selectively Abolishes Interleukin-17 Responses in Humans with Chronic Mucocutaneous Candidiasis

(2013) Bertrand Boisson et al.   IMMUNITY

The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections

(2013) Shrinivas Bishu et al.   INFECTION AND IMMUNITY

Molecular epidemiology, phylogeny and evolution of Candida albicans

(2013) Brenda A. McManus et al.   INFECTION GENETICS AND EVOLUTION

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency

(2013) Haifa H. Jabara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies

(2013) Xiaowen Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rare case of fungal keratitis caused by Corynespora cassiicola

(2013) Hiroki Yamada et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Deep Dermatophytosis and Inherited CARD9 Deficiency

(2013) Fanny Lanternier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Candida and Host Determinants of Susceptibility to Invasive Candidiasis

(2013) Michail S. Lionakis et al.   PLoS Pathogens

Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm

(2013) Nicolas Papon et al.   PLoS Pathogens

Impact of lymphocyte and monocyte recovery on the outcomes of allogeneic hematopoietic SCT with fludarabine and melphalan conditioning

(2012) L J DeCook et al.   BONE MARROW TRANSPLANTATION

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

(2012) Anne Puel et al.   Current Opinion in Allergy and Clinical Immunology

Immunity to infection in IL-17-deficient mice and humans

(2012) Sophie Cypowyj et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

Diagnosis and treatment of postpartum Candida endophthalmitis

(2012) Jae Hyung Lee et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome

(2012) Marie-Olivia Chandesris et al.   MEDICINE

Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa

(2012) Lu-juan Gao et al.   MYCOPATHOLOGIA

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

(2012) Anupam Jhingran et al.   Cell Reports

Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency

(2011) J. Cuellar-Rodriguez et al.   BLOOD

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

Emergence of Aureobasidium pullulans as human fungal pathogen and molecular assay for future medical diagnosis

(2011) Giek Far Chan et al.   FOLIA MICROBIOLOGICA

Invasive cutaneous Trichophyton shoenleinii infection in an immunosuppressed patient

(2011) Petronius Dan et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Successful Treatment of Chronic Mucocutaneous Candidiasis Caused by Azole-ResistantCandida albicanswith Posaconazole

(2010) Davide Firinu et al.   Clinical & Developmental Immunology

Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001–2006: Overview of the Transplant‐Associated Infection Surveillance Network (TRANSNET) Database

(2010) Dimitrios P. Kontoyiannis et al.   CLINICAL INFECTIOUS DISEASES

Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)

(2010) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Melanized Fungi in Human Disease

(2010) S. G. Revankar et al.   CLINICAL MICROBIOLOGY REVIEWS

Chronic mucocutaneous candidiasis and congenital susceptibility to Candida

(2010) Erik Glocker et al.   Current Opinion in Allergy and Clinical Immunology

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

(2010) Rebecca A. Drummond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Organ-Specific Innate Immune Responses in a Mouse Model of Invasive Candidiasis

(2010) Michail S. Lionakis et al.   Journal of Innate Immunity

Disseminated dermatophytosis in a patient with hereditary hemochromatosis and hepatic cirrhosis: case report and review of the literature

(2010) Vincent C. Marconi et al.   MEDICAL MYCOLOGY

Role of NADPH oxidase in host defense against aspergillosis

(2010) Melissa J. Grimm et al.   MEDICAL MYCOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

CARD9 Signaling in the Innate Immune Response

(2009) Jürgen Ruland   Annals of the New York Academy of Sciences

Unrelated donor and HLA-identical sibling haematopoietic stem cell transplantation cure chronic granulomatous disease with good long-term outcome and growth

(2009) Elena Soncini et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex

(2009) Weihui Wu et al.   NATURE IMMUNOLOGY

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Aspergillosis

(2009) Brahm H. Segal   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Host Specialization and Phylogenetic Diversity ofCorynespora cassiicola

(2009) L. J. Dixon et al.   PHYTOPATHOLOGY

Hematopoietic cell transplantation for correction of primary immunodeficiencies

(2008) A H Filipovich   BONE MARROW TRANSPLANTATION

Modern management of chronic granulomatous disease

(2008) Reinhard A. Seger   BRITISH JOURNAL OF HAEMATOLOGY

Update in Antifungal Therapy of Dermatophytosis

(2008) Aditya K. Gupta et al.   MYCOPATHOLOGIA

Epidemiological trends in skin mycoses worldwide

(2008) Blanka Havlickova et al.   MYCOSES

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY