Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma

(2019) Luc-Matthieu Fornecker et al.   Scientific Reports

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

(2019) Robin Beekhof et al.   Molecular Systems Biology

B-cell specific IRF4 deletion accelerates Chronic Lymphocytic Leukemia development by enhanced tumor immune evasion

(2019) Daniela Asslaber et al.   BLOOD

Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

(2019) Bader Alanazi et al.   LEUKEMIA

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model

(2018) Marina García-Peydró et al.   JOURNAL OF CLINICAL INVESTIGATION

PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation

(2018) Santiago Nahuel Villegas et al.   Cell Reports

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

(2018) Nadja Zaborsky et al.   LEUKEMIA

Loss of NFAT2 expression results in the acceleration of clonal evolution in chronic lymphocytic leukemia

(2018) David J. Müller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies

(2018) Francesca Arruga et al.   Frontiers in Oncology

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways

(2017) D Benedetti et al.   LEUKEMIA

NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia

(2017) Melanie Märklin et al.   Nature Communications

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

(2017) Chenhui Wang et al.   Nature Communications

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice

(2016) G. Knittel et al.   BLOOD

Functional and Clinical Significance of the Integrin Alpha Chain CD49d Expression in Chronic Lymphocytic Leukemia

(2016) Michele Dal Bo et al.   CURRENT CANCER DRUG TARGETS

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia

(2016) E Young et al.   LEUKEMIA

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Richter syndrome: pathogenesis and management

(2016) Davide Rossi et al.   SEMINARS IN ONCOLOGY

Richter transformation of CLL

(2016) Nitin Jain et al.   Expert Review of Hematology

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

(2015) Jessica Okosun et al.   NATURE GENETICS

The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia

(2015) Julia Christine Gutjahr et al.   Frontiers in Immunology

How we treat Richter syndrome

(2014) S. A. Parikh et al.   BLOOD

Constitutive AKT activation in follicular lymphoma

(2014) Ouardia I Yahiaoui et al.   BMC CANCER

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

(2014) G. Packham et al.   HAEMATOLOGICA

Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand

(2014) Jung-Ah Kang et al.   IMMUNOLOGY

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome

(2013) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1

(2013) Maria Elena De Obaldia et al.   NATURE IMMUNOLOGY

Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells

(2013) Audun Os et al.   Cell Reports

Notch Suppresses Nuclear Factor of Activated T Cells (Nfat) Transactivation andNfatc1Expression in Chondrocytes

(2012) Stefano Zanotti et al.   ENDOCRINOLOGY

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

(2011) Oliver Stöhr et al.   AGE

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling

(2011) F. Hampel et al.   BLOOD

The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation

(2011) D. Rossi et al.   BLOOD

B-cell receptor signaling in chronic lymphocytic leukemia

(2011) F. K. Stevenson et al.   BLOOD

NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

(2011) Sankar Bhattacharyya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome

(2009) D. Rossi et al.   CLINICAL CANCER RESEARCH

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

(2008) I. Joshi et al.   BLOOD

Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome

(2008) Davide Rossi et al.   BRITISH JOURNAL OF HAEMATOLOGY

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism