期刊
IMMUNOLOGY
卷 143, 期 4, 页码 550-559出版社
WILEY
DOI: 10.1111/imm.12333
关键词
B cell; B-cell receptor; Notch ligand; Notch1
类别
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2011-0029179]
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A111838]
- GIST-Caltech research Collaboration
- Bioimaging research center project through GIST
- Korea Health Promotion Institute [A111838] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2011-0029179] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand.
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