A genome‐scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures

Integration of Time-Series Transcriptomic Data with Genome-Scale CHO Metabolic Models for mAb Engineering

(2020) Zhuangrong Huang et al.   Processes

What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

(2020) Diana Széliová et al.   METABOLIC ENGINEERING

Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli

(2019) Mattia Zampieri et al.   Nature Communications

Machine and deep learning meet genome-scale metabolic modeling

(2019) Guido Zampieri et al.   PLoS Computational Biology

Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms

(2019) Bergthor Traustason et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies

(2018) Frank V. Ritacco et al.   BIOTECHNOLOGY PROGRESS

Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

(2018) Cyrielle Calmels et al.   METABOLIC ENGINEERING

In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

(2017) Hemlata Bhatia et al.   ENGINEERING IN LIFE SCIENCES

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

A hybrid approach identifies metabolic signatures of high-producers for chinese hamster ovary clone selection and process optimization

(2016) Oliver Popp et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

(2016) Hooman Hefzi et al.   Cell Systems

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic responses of CHO cells to limitation of key amino acids

(2014) Tiago M. Duarte et al.   BIOTECHNOLOGY AND BIOENGINEERING

optGpSampler: An Improved Tool for Uniformly Sampling the Solution-Space of Genome-Scale Metabolic Networks

(2014) Wout Megchelenbrink et al.   PLoS One

Cellular responses to individual amino-acid depletion in antibody-expressing and parental CHO cell lines

(2013) Dina Fomina-Yadlin et al.   BIOTECHNOLOGY AND BIOENGINEERING

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

(2013) Ali Ebrahim et al.   BMC Systems Biology

Network Context and Selection in the Evolution to Enzyme Specificity

(2012) H. Nam et al.   SCIENCE

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

(2011) Jan Schellenberger et al.   Nature Protocols

The biomass objective function

(2010) Adam M Feist et al.   CURRENT OPINION IN MICROBIOLOGY