Molecular imaging for mitochondrial metabolism and oxidative stress in mitochondrial diseases and neurodegenerative disorders

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

(2020) Tatsuhiro Terada et al.   NEUROLOGY

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

PET imaging of 11C-labeled coenzyme Q10: Comparison of biodistribution between [11C]ubiquinol-10 and [11C]ubiquinone-10

(2019) Kyosuke Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantifying normal human brain metabolism using hyperpolarized [1–13C]pyruvate and magnetic resonance imaging

(2019) James T. Grist et al.   NEUROIMAGE

Causative Links between Protein Aggregation and Oxidative Stress: A Review

(2019) Elise Lévy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genetic architecture of Parkinson's disease

(2019) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

(2019) Masamichi Ikawa et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Anatomic & metabolic brain markers of the m.3243A>G mutation: A multi-parametric 7T MRI study

(2018) Roy A.M. Haast et al.   NeuroImage-Clinical

Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in Patients with Parkinson’s Disease: A Study with 62Cu-ATSM PET and 123I-FP-CIT SPECT

(2017) Hiroyuki Neishi et al.   EUROPEAN NEUROLOGY

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

(2017) James B. Hilton et al.   Scientific Reports

Differential diagnosis of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and ischemic stroke using 3D pseudocontinuous arterial spin labeling

(2016) Rui Li et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

(2015) M. Ikawa et al.   NEUROLOGY

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Functional Imaging of Oxidative Stress with a Novel PET Imaging Agent, 18F-5-Fluoro-L-Aminosuberic Acid

(2014) J. M. Webster et al.   JOURNAL OF NUCLEAR MEDICINE

Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer

(2014) D. M. Wilson et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers

(2014) N. Weiduschat et al.   NEUROLOGY

Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients

(2014) Koji Abe et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Evaluation of 18F-BCPP-EF for mitochondrial complex 1 imaging in the brain of conscious monkeys using PET

(2013) Hideo Tsukada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology

(2013) Subhashini Bolisetty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients

(2013) Masamichi Ikawa et al.   MITOCHONDRION

Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

(2012) Masamichi Ikawa et al.   EUROPEAN NEUROLOGY

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

In vivo functional brain imaging and a therapeutic trial of l-arginine in MELAS patients

(2011) Makoto Yoneda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease

(2011) Makoto Isozaki et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET

(2011) Masamichi Ikawa et al.   NUCLEAR MEDICINE AND BIOLOGY

Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation

(2011) Yukie Yoshii et al.   NUCLEAR MEDICINE AND BIOLOGY

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

(2011) P. S. Donnelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral metabolism of oxygen and glucose in a patient with MELAS syndrome

(2010) M. Sano et al.   ACTA NEUROLOGICA SCANDINAVICA

Energy States in Mitochondrial Cardiomyopathy

(2010) Masamichi Ikawa et al.   CIRCULATION JOURNAL

Abnormal Myocardial Energy-Production State in Mitochondrial Cardiomyopathy and Acute Response to L-Arginine Infusion

(2010) Kenichiro Arakawa et al.   CIRCULATION JOURNAL

Parkinson's disease: Mitochondrial damage control

(2010) Asa Abeliovich   NATURE

Disruption of Endothelial Tight Junctions in a Patient with Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS)

(2010) M. Matsuzaki et al.   NEUROPEDIATRICS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images

(2009) Tetsuya Tsujikawa et al.   BRAIN & DEVELOPMENT

Accumulation of oxidative stress around the stroke-like lesions of MELAS patients

(2009) Yuri Katayama et al.   MITOCHONDRION

PET imaging of redox and energy states in stroke-like episodes of MELAS

(2009) Masamichi Ikawa et al.   MITOCHONDRION

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL