期刊
MITOCHONDRION
卷 9, 期 2, 页码 144-148出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2009.01.011
关键词
MELAS; Stroke-like episodes; Oxidative stress; Over-reduction state; PET; Functional imaging
资金
- National Institute of Radiological Sciences, Chiba, Japan
- Japan Society for the Promotion of Science [17209040]
- 21st Century COE Program (Medical Science)
- Grants-in-Aid for Scientific Research [17209040] Funding Source: KAKEN
In stroke-like episodes of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), changes in oxidative stress and glucose metabolism and their sequence remain obscure. We developed a novel double imaging method using positron emission tomography (PET) with [Cu-62]-diacetyl-bis(N4-methylthiosemicarbazone) ((CU)-C-62-ATSM) and [F-18]-fluorodeoxyglucose ((18)FDG) to visualize the regional oxidative stress, glucose metabolism and blood flow in brain lesions of stroke-like episodes non-invasively and rapidly. These PET imagings were performed on a MELAS patient with stroke-like lesions, and clearly demonstrated that oxidative stress following hyperemia along with increased glucose metabolism plays crucial roles in the pathogenesis of MELAS stroke-like episodes. (C) 2009 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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