期刊
EUROPEAN NEUROLOGY
卷 78, 期 3-4, 页码 161-168出版社
KARGER
DOI: 10.1159/000479627
关键词
Cu-62-ATSM PET; I-123-FP-CIT SPECT; Parkinson's disease; Oxidative stress; Mitochondrial dysfunction; Dopaminergic neuron
资金
- Japan Society for the Promotion of Science [15K15453, 16K09712]
- Grants-in-Aid for Scientific Research [16K09712, 15H01846, 15K09440, 15K15453] Funding Source: KAKEN
Background: This study sought to precisely evaluate striatal oxidative stress and its relationship with the disease severity in Parkinson's disease (PD) using double brain imaging, Cu-62-diacetyl- bis (N-4-methylthiosemicarbazone) (Cu-62-ATSM) PET and I-123-FP-CIT SPECT. Methods: Nine PD patients were studied with brain Cu-62-ATSM PET for oxidative stress and I-123-FPCIT SPECT for the density of striatal dopamine transporter. Standardized uptake values (SUVs) were obtained from the delayed phase of dynamic Cu-62-ATSM PET, and striatum-tocerebellum SUV ratio (SUVR) was calculated. To correct the effect of neuronal loss in the striatum, Cu-62-ATSM SUVR was corrected for striatal specific binding ratio (SBR) values of I-123-FP-CIT (SUVR/SBR). Results: Cu-62-ATSM SUVR without correction was not significantly correlated with disease severity estimated by the Unified Parkinson's Disease Rating Scale (UPDRS) scores or I-123-FP-CIT SBR. In contrast, the SUVR/SBR showed significant correlations with the UPDRS total and motor scores, and I-123-FP-CIT SBR. Conclusion: Oxidative stress in the remaining striatal dopaminergic neurons estimated by SUVR/SBR was increased with disease severity in PD patients, suggesting that oxidative stress based on mitochondrial dysfunction contributes to promoting dopaminergic neuronal degeneration in PD. Cu-62-ATSM PET with (IFP)-I-123- CIT SPECT correction would be a promising tool to evaluate dopaminergic neuronal oxidative stress in PD. (C) 2017 S. Karger AG, Basel
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