Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Cationic HDL mimetics enhance in vivo delivery of self-replicating mRNA

(2020) Wei He et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

(2020) Philipp A. Ilinykh et al.   Cell Host & Microbe

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

(2020) Alba Grifoni et al.   Cell Host & Microbe

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

(2020) Hisashi Kai et al.   HYPERTENSION RESEARCH

Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2

(2020) Kazuma Kiyotani et al.   JOURNAL OF HUMAN GENETICS

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Ethics of controlled human infection to address COVID-19

(2020) Seema K. Shah et al.   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

Immunogenicity of a DNA vaccine candidate for COVID-19

(2020) Trevor R. F. Smith et al.   Nature Communications

Mechanism of Virus Attenuation by Codon Pair Deoptimization

(2020) Nicole Groenke et al.   Cell Reports

Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction

(2020) Kelly R. Rhodes et al.   Acta Biomaterialia

Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2

(2020) Hui Wang et al.   CELL

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

(2020) Lianpan Dai et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice

(2020) James Brett Case et al.   Cell Host & Microbe

COVID-19 pathophysiology: A review

(2020) Koichi Yuki et al.   CLINICAL IMMUNOLOGY

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes

(2020) Shengli Xia et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Feng-Cai Zhu et al.   LANCET

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models

(2020) Meagan E. Deming et al.   NEW ENGLAND JOURNAL OF MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

(2020) Xiangyang Chi et al.   SCIENCE

SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses

(2020) He-wei Jiang et al.   Nature Communications

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

COVID-19 and the Path to Immunity

(2020) David S. Stephens et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

What can we expect from first-generation COVID-19 vaccines?

(2020) Malik Peiris et al.   LANCET

COVID-19 vaccine trials should seek worthwhile efficacy

(2020) Philip Krause et al.   LANCET

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

(2020) Christopher O. Barnes et al.   NATURE

Emergency Use Authorization of Covid Vaccines — Safety and Efficacy Follow-up Considerations

(2020) Philip R. Krause et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding COVID-19 vaccine efficacy

(2020) Marc Lipsitch et al.   SCIENCE

Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac – PROFISCOV: A structured summary of a study protocol for a randomised controlled trial

(2020) Ricardo Palacios et al.   Trials

As Plain as the Nose on Your Face: The Case for A Nasal (Mucosal) Route of Vaccine Administration for Covid-19 Disease Prevention

(2020) Craig R. Travis   Frontiers in Immunology

Racial and Ethnic Disparities Among COVID-19 Cases in Workplace Outbreaks by Industry Sector — Utah, March 6–June 5, 2020

(2020) David P. Bui et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

Why Oxford’s positive COVID vaccine results are puzzling scientists

(2020) Ewen Callaway   NATURE

RNA Modifications Modulate Activation of Innate Toll-Like Receptors

(2019) Isabel Freund et al.   Genes

Development of Pyro-Drive Jet Injector With Controllable Jet Pressure

(2019) Hiroshi Miyazaki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants

(2019) Sita Awasthi et al.   VACCINE

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

(2019) Kayvon Modjarrad et al.   LANCET INFECTIOUS DISEASES

Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults

(2019) Stéphane Pillet et al.   PLoS One

A phase 2, prospective, randomized, multicenter, open-label study of GX-188E, an HPV DNA vaccine, in patients with cervical intraepithelial neoplasia 3

(2019) Youn Jin Choi et al.   CLINICAL CANCER RESEARCH

Algorithm-based liquid formulation development including a DoE concept predicts long-term viral vector stability

(2019) E.B. Reinauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector

(2019) Chinyang Chang et al.   AAPS PHARMSCITECH

One-step artificial antigen presenting cell-based vaccines induce potent effector CD8 T cell responses

(2019) Qingtai Su et al.   Scientific Reports

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

(2018) Sofia E. Magnusson et al.   IMMUNOLOGIC RESEARCH

Combination attenuation offers strategy for live-attenuated coronavirus vaccines

(2018) Vineet D. Menachery et al.   JOURNAL OF VIROLOGY

The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

(2018) Ellen Suder et al.   Human Vaccines & Immunotherapeutics

The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

(2018) Julia Bally et al.   Annual Review of Phytopathology

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

(2018) Robert N. Kirchdoerfer et al.   Scientific Reports

Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial

(2018) Emil C Reisinger et al.   LANCET

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

(2018) Harm HogenEsch et al.   npj Vaccines

SalmonellaVaccines: Conduits for Protective Antigens

(2017) Josephine E. Clark-Curtiss et al.   JOURNAL OF IMMUNOLOGY

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Feng-Cai Zhu et al.   LANCET

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

A Recombinant Vesicular Stomatitis Virus Ebola Vaccine

(2017) Jason A. Regules et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs

(2017) Chao Wang et al.   Theranostics

A thermostable messenger RNA based vaccine against rabies

(2017) Lothar Stitz et al.   PLoS Neglected Tropical Diseases

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

(2017) Masayuki Hayashi et al.   EBioMedicine

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

(2017) Johannes Lutz et al.   npj Vaccines

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

(2016) Carole J. Henry Dunand et al.   Cell Host & Microbe

Parenteral Vaccination Can Be an Effective Means of Inducing Protective Mucosal Responses

(2016) John D. Clements et al.   Clinical and Vaccine Immunology

Molecular pharming — VLPs made in plants

(2016) Johanna Marsian et al.   CURRENT OPINION IN BIOTECHNOLOGY

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

(2016) Selidji T. Agnandji et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens

(2016) Gokul Swaminathan et al.   VACCINE

A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

(2016) Wanbo Tai et al.   VIROLOGY

Induction of mucosal immunity through systemic immunization: Phantom or reality?

(2016) Fei Su et al.   Human Vaccines & Immunotherapeutics

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

(2016) Gene S. Tan et al.   PLoS Pathogens

Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes

(2016) Theone C. Kon et al.   PLoS One

Systemic and mucosal immune responses following oral adenoviral delivery of influenza vaccine to the human intestine by radio controlled capsule

(2016) Leesun Kim et al.   Scientific Reports

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial

(2015) Katrin Ramsauer et al.   LANCET INFECTIOUS DISEASES

Innate Responses Induced by Whole Inactivated Virus or Subunit Influenza Vaccines in Cultured Dendritic Cells Correlate with Immune Responses In Vivo

(2015) Maaike Stoel et al.   PLoS One

Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer

(2015) Marcela de Azevedo et al.   VACCINE

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

(2014) Ozan S. Kumru et al.   BIOLOGICALS

Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of meningitis A vaccine in Chad

(2014) Patrick Lydon et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node

(2014) J. M. Thompson et al.   JOURNAL OF IMMUNOLOGY

Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

(2014) Yoshikazu Honda-Okubo et al.   JOURNAL OF VIROLOGY

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

Matrix-M™ adjuvant: enhancing immune responses by ‘setting the stage’ for the antigen

(2013) Karin Lövgren Bengtsson et al.   Expert Review of Vaccines

The Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly[2-(dimethylamino)ethyl methacrylate]-Based siRNA Complexes

(2013) Dana J. Gary et al.   MACROMOLECULAR BIOSCIENCE

A decade after SARS: strategies for controlling emerging coronaviruses

(2013) Rachel L. Graham et al.   NATURE REVIEWS MICROBIOLOGY

New paradigms for functional HIV-specific nonneutralizing antibodies

(2013) Don Forthal et al.   Current Opinion in HIV and AIDS

Tolerability of intramuscular and intradermal delivery by CELLECTRA®adaptive constant current electroporation device in healthy volunteers

(2013) Malissa C Diehl et al.   Human Vaccines & Immunotherapeutics

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

Correction: Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Matrix-M™ Adjuvant Induces Local Recruitment, Activation and Maturation of Central Immune Cells in Absence of Antigen

(2012) Jenny M. Reimer et al.   PLoS One

RNA-based vaccines

(2012) Jeffrey B. Ulmer et al.   VACCINE

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines

(2011) S. Kreiter et al.   CANCER RESEARCH

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

(2011) Dan H. Barouch et al.   VACCINE

Evaluation of a virosomal H5N1 vaccine formulated with Matrix M™ adjuvant in a phase I clinical trial

(2011) Rebecca J. Cox et al.   VACCINE

A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan

(2010) Eric HY Lau et al.   BMC INFECTIOUS DISEASES

Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA

(2010) Elizabeth S. Gabitzsch et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

DNA vaccines for targeting bacterial infections

(2010) Mariana Ingolotti et al.   Expert Review of Vaccines

Delta inulin: a novel, immunologically active, stable packing structure comprising  -D-[2 -> 1] poly(fructo-furanosyl)  -D-glucose polymers

(2010) P. D. Cooper et al.   GLYCOBIOLOGY

Vaccine stability study design and analysis to support product licensure

(2009) Timothy L. Schofield   BIOLOGICALS

Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity

(2009) T Osada et al.   CANCER GENE THERAPY

SARS vaccines: where are we?

(2009) Rachel L Roper et al.   Expert Review of Vaccines

Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein

(2009) K Yang et al.   GENE THERAPY

Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity

(2009) Yeu-Chun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Influenza Vaccine Manufacture: Keeping Up with Change

(2009) Kathleen M. Neuzil et al.   JOURNAL OF INFECTIOUS DISEASES

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of action of licensed vaccine adjuvants

(2009) Elaine Tritto et al.   VACCINE

Highly efficient in vivo gene transfection by plasmid/PEI complexes coated by anionic PEG derivatives bearing carboxyl groups and RGD peptide

(2008) Mitsuko Sakae et al.   BIOMEDICINE & PHARMACOTHERAPY

A preliminary and comparative evaluation of a novel Ad5 [E1-, E2b-] recombinant-based vaccine used to induce cell mediated immune responses

(2008) Elizabeth S. Gabitzsch et al.   IMMUNOLOGY LETTERS

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults

(2008) Pierre Van Damme et al.   VACCINE

SARS vaccine based on a replication-defective recombinant vesicular stomatitis virus is more potent than one based on a replication-competent vector

(2008) Sagar U. Kapadia et al.   VIROLOGY

Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways

(2007) Bruce A. Kerwin   JOURNAL OF PHARMACEUTICAL SCIENCES

Human immunopathogenesis of severe acute respiratory syndrome (SARS)

(2007) Mark J. Cameron et al.   VIRUS RESEARCH