Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults

Vaccines for the elderly: current use and future challenges

(2018) Birgit Weinberger   Immunity & Ageing

Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial

(2018) Stéphane Pillet et al.   npj Vaccines

Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older

(2017) Lisa M. Dunkle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages

(2017) Alexander I. Makarkov et al.   VACCINE

Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs

(2017) Nana H. Overgaard et al.   VACCINE

Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro

(2017) Hilary E. Hendin et al.   VACCINE

AS03- and MF59-Adjuvanted Influenza Vaccines in Children

(2017) Amanda L. Wilkins et al.   Frontiers in Immunology

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Aging of the immune system: Focus on inflammation and vaccination

(2016) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Influenza immunology evaluation and correlates of protection: a focus on vaccines

(2016) Claudia Maria Trombetta et al.   Expert Review of Vaccines

High-dose influenza vaccine in older adults

(2016) Joyce M. Wang et al.   JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain

(2016) Donald D Raymond et al.   NATURE MEDICINE

The confounded effects of age and exposure history in response to influenza vaccination

(2016) Ana Mosterín Höpping et al.   VACCINE

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

(2015) Andrew C. Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Generation and characterization of a trackable plant-made influenza H5 virus-like particle (VLP) containing enhanced green fluorescent protein (eGFP)

(2015) Katie R. Young et al.   FASEB JOURNAL

Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets

(2015) S. Pillet et al.   VACCINE

Safe vaccination of patients with egg allergy by using live attenuated influenza vaccine

(2015) Anne Des Roches et al.   Journal of Allergy and Clinical Immunology-In Practice

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Modeling the Effect of Different Vaccine Effectiveness Estimates on the Number of Vaccine-Prevented Influenza-Associated Hospitalizations in Older Adults

(2014) Alicia M. Fry et al.   CLINICAL INFECTIOUS DISEASES

Ageing and respiratory infections: The airway of ageing

(2014) Kamran Haq et al.   IMMUNOLOGY LETTERS

Longevity of B-Cell and T-Cell Responses After Live Attenuated Influenza Vaccination in Children

(2014) K. G.- I. Mohn et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged ≥18 years: A phase III, randomized trial

(2014) Juan Carlos Tinoco et al.   VACCINE

Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines

(2014) Brian J. Ward et al.   VACCINE

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

(2013) K. Kai McKinstry et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged ≥18 years

(2013) Dorothee Kieninger et al.   BMC INFECTIOUS DISEASES

Patients Hospitalized With Laboratory-Confirmed Influenza During the 2010-2011 Influenza Season: Exploring Disease Severity by Virus Type and Subtype

(2013) S. S. Chaves et al.   JOURNAL OF INFECTIOUS DISEASES

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses

(2013) F. Spensieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Immunogenicity and safety of Fluzone® intradermal and high-dose influenza vaccines in older adults ≥65 years of age: A randomized, controlled, phase II trial

(2013) Peter Tsang et al.   VACCINE

Hospitalizations Associated With Influenza and Respiratory Syncytial Virus in the United States, 1993–2008

(2012) Hong Zhou et al.   CLINICAL INFECTIOUS DISEASES

Egg-allergic patients can be safely vaccinated against influenza

(2012) Anne Des Roches et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

(2012) Janet E. McElhaney et al.   VACCINE

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Humoral and Cell-Mediated Immunity to Pandemic H1N1 Influenza in a Canadian Cohort One Year Post-Pandemic: Implications for Vaccination

(2011) Lisa E. Wagar et al.   PLoS One

Immunogenicity and safety of inactivated influenza vaccines in primed populations: A systematic literature review and meta-analysis

(2011) W.E.P. Beyer et al.   VACCINE

Influenza vaccine responses in older adults

(2010) Janet E. McElhaney   AGEING RESEARCH REVIEWS

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination

(2010) Ramu A. Subbramanian et al.   VACCINE

Lung homing CTLs and their proliferation ability are important correlates of vaccine protection against influenza

(2010) Jianping Lin et al.   VACCINE

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

(2008) B. D. Forrest et al.   Clinical and Vaccine Immunology

Biology of Immune Responses to Vaccines in Elderly Persons

(2008) Birgit Weinberger et al.   CLINICAL INFECTIOUS DISEASES