Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

The dynamics of γ-secretase and its substrates

(2020) Manuel Hitzenberger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The substrate repertoire of γ-secretase/presenilin

(2020) Gökhan Güner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase

(2019) Sara Suna Yücel et al.   Cell Reports

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

(2019) Torben Mentrup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage

(2019) Alexander Götz et al.   BIOPHYSICAL JOURNAL

Signal peptide peptidase‐like 2c impairs vesicular transport and cleaves SNARE proteins

(2019) Alkmini A Papadopoulou et al.   EMBO REPORTS

Conformationally Flexible Sites within the Transmembrane Helices of Amyloid Precursor Protein and Notch1 Receptor

(2019) Walter Stelzer et al.   BIOCHEMISTRY

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix

(2018) Philipp Högel et al.   BIOCHEMISTRY

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

(2018) Sandra Stefanovic‐Barrett et al.   EMBO REPORTS

Dissecting conformational changes in APP’s transmembrane domain linked to ε-efficiency in familial Alzheimer’s disease

(2018) Alexander Götz et al.   PLoS One

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding

(2018) Linda Schauenburg et al.   Scientific Reports

Latest emerging functions of SPP/SPPL intramembrane proteases

(2017) Torben Mentrup et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74

(2016) S. Huttl et al.   BIOCHEMICAL JOURNAL

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ

(2016) Marty A. Fernandez et al.   BIOCHEMISTRY

The life cycle of the low-density lipoprotein receptor

(2015) Melinde Wijers et al.   CURRENT OPINION IN LIPIDOLOGY

Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways

(2015) Peer-Hendrik Kuhn et al.   MOLECULAR & CELLULAR PROTEOMICS

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

(2015) David M. Bolduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases

(2015) Torben Mentrup et al.   TRAFFIC

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

(2015) D. Langosch et al.   TRENDS IN BIOCHEMICAL SCIENCES

γ-secretase directly sheds the survival receptor BCMA from plasma cells

(2015) Sarah A. Laurent et al.   Nature Communications

Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

(2014) Christina Scharnagl et al.   BIOPHYSICAL JOURNAL

Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation

(2014) Matthias Voss et al.   EMBO JOURNAL

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

(2014) C.-y. Chen et al.   EMBO JOURNAL

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

(2014) Jessica M. Boname et al.   JOURNAL OF CELL BIOLOGY

Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity

(2014) F-F Hsu et al.   ONCOGENE

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

γ-Secretase-Regulated Signaling Typified by Notch Signaling in the Immune System

(2013) Hisashi Nagase et al.   Current Stem Cell Research & Therapy

Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)

(2012) Matthias Voss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase

(2012) Oxana Pester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Shifting hydrogen bonds may produce flexible transmembrane helices

(2012) Z. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b)

(2011) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices

(2010) Stefan Quint et al.   BIOPHYSICAL JOURNAL

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Membrane protein folding: how important are hydrogen bonds?

(2010) James U Bowie   CURRENT OPINION IN STRUCTURAL BIOLOGY

The proteome of lysosomes

(2010) Bernd A. Schröder et al.   PROTEOMICS

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

Sequence-Specific Conformational Dynamics of Model Transmembrane Domains Determines Their Membrane Fusogenic Function

(2009) Bernhard C. Poschner et al.   JOURNAL OF MOLECULAR BIOLOGY

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation

(2008) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis

(2008) Lucas Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY