Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

An Updated Review of Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer’s Patients

(2020) Haolong Liu et al.   Frontiers in Pharmacology

Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

(2020) Mohamed A. Salem et al.   Metabolites

Discovery of Helminthosporin, an Anthraquinone Isolated from Rumex abyssinicus Jacq as a Dual Cholinesterase Inhibitor

(2020) Ntemafack Augustin et al.   ACS Omega

Bioactivity-Guided Identification of Anti-Adipogenic Isothiocyanates in the Moringa (Moringa oleifera) Seed and Investigation of the Structure-Activity Relationship

(2020) Linhua Huang et al.   MOLECULES

Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition

(2020) Bathini Thissera et al.   SOUTH AFRICAN JOURNAL OF BOTANY

A comprehensive study on narcissus tazetta subsp. tazetta L.: Chemo-profiling, isolation, anticholinesterase activity and molecular docking of amaryllidaceae alkaloids

(2020) Ç. Karakoyun et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Carbonic anhydrase and cholinesterase inhibitory activities of isolated flavonoids from Oxalis corniculata L. and their first-principles investigations

(2020) Muhammad Imran et al.   INDUSTRIAL CROPS AND PRODUCTS

Honokiol ameliorates angiotensin II‐induced hypertension and endothelial dysfunction by inhibiting HDAC6‐mediated cystathionine γ‐lyase degradation

(2020) Zhexi Chi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lupeol Counteracts the Proinflammatory Signalling Triggered in Macrophages by 7-Keto-Cholesterol: New Perspectives in the Therapy of Atherosclerosis

(2020) Sarmistha Saha et al.   Oxidative Medicine and Cellular Longevity

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling

(2020) Shan Lu et al.   Frontiers in Pharmacology

Constituents of Talisia nervosa with Potential Utility against Metabolic Syndrome

(2019) Yelkaira Vásquez et al.   Natural Product Communications

Dihydromyricetin Inhibits α-Synuclein Aggregation, Disrupts Preformed Fibrils, and Protects Neuronal Cells in Culture against Amyloid-Induced Cytotoxicity

(2019) Longgang Jia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson’s Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways

(2019) Jin-Sun Park et al.   Biomolecules & Therapeutics

Identification of embelin, a 3‐undecyl‐1,4‐benzoquinone from Embelia ribes as a multitargeted anti‐Alzheimer agent

(2019) Vijay K. Nuthakki et al.   DRUG DEVELOPMENT RESEARCH

Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities

(2019) Sara Freitas et al.   Marine Drugs

Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics

(2019) Xiang-tao Huang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches

(2019) Juan F. González et al.   Expert Opinion on Drug Discovery

Antidiabetic Activity of Acidic Polysaccharide From Schisandra chinensis in STZ-Induced Diabetic Mice

(2019) Xue Tao et al.   Natural Product Communications

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Chemical composition, antioxidant activity and inhibitory capacity of α-amylase, α-glucosidase, lipase and non-enzymatic glycation, in vitro, of the leaves of Cassia bakeriana Craib

(2019) Tiara da Costa Silva et al.   INDUSTRIAL CROPS AND PRODUCTS

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

(2019) Gaia Fancellu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

α-Glucosidase inhibitory activity and in vivo antihyperglycemic effect of secondary metabolites from the leaf infusion of Ocimum campechianum mill

(2019) Javier A. Ruiz-Vargas et al.   JOURNAL OF ETHNOPHARMACOLOGY

Terminalia Arjuna bark extract impedes foam cell formation and promotes apoptosis in ox-LDL-stimulated macrophages by enhancing UPR-CHOP pathway

(2019) Shipra Bhansali et al.   Lipids in Health and Disease

α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives

(2019) Yuri Yoshioka et al.   MOLECULES

Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates

(2019) Shamini Vijayakumaran et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Anti-adipogenic Effect of β-Carboline Alkaloids from Garlic (Allium sativum)

(2019) Su Cheol Baek et al.   Foods

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

Bioactivities of Phenolics by Focusing on Suppression of Chronic Diseases: A Review

(2018) Fereidoon Shahidi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum

(2018) Zeljka Rupcic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

(2018) Shreekrishna Lamichane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application

(2018) Ana Seca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells

(2018) Kuljeet S. Gugnani et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of Peptides for the Management of Alzheimer’s Disease: Diagnosis and Inhibition

(2018) Mohammad H. Baig et al.   Frontiers in Aging Neuroscience

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

(2018) Sara Anna Bonini et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation

(2018) Antonio Laghezza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease

(2018) Luca Piemontese et al.   MOLECULES

A bile acid derivative with PPARγ-mediated anti-inflammatory activity

(2018) Sen Liu et al.   STEROIDS

Secondary metabolites from lichen as potent inhibitors of advanced glycation end products and vasodilative agents

(2018) Andreas Schinkovitz et al.   FITOTERAPIA

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

(2018) Long-He Yang et al.   Marine Drugs

Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B

(2017) Narayan D. Chaurasiya et al.   Evidence-based Complementary and Alternative Medicine

Endocannabinoid system in neurodegenerative disorders

(2017) Balapal S. Basavarajappa et al.   JOURNAL OF NEUROCHEMISTRY

Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B

(2017) Jutta Wiese et al.   Marine Drugs

Deep Eutectic Solvents as Novel and Effective Extraction Media for Quantitative Determination of Ochratoxin A in Wheat and Derived Products

(2017) Luca Piemontese et al.   MOLECULES

In vitro neuroprotective potential of lichen metabolite fumarprotocetraric acid via intracellular redox modulation

(2017) Carlos Fernández-Moriano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia

(2017) Ghada Ahmed Fawzy et al.   SAUDI PHARMACEUTICAL JOURNAL

Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens

(2016) Hyun Woo Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Waste grape skins: evaluation of safety aspects for the production of functional powders and extracts for the food sector

(2016) Alessandro Moncalvo et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids

(2016) Simone Carradori et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plant polyphenols as natural drugs for the management of Down syndrome and related disorders

(2016) Rosa Anna Vacca et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lichen-derived compounds show potential for central nervous system therapeutics

(2016) R. Gajendra Reddy et al.   PHYTOMEDICINE

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles

(2015) Antonio Laghezza et al.   ChemMedChem

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175

(2015) Luca Piemontese et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32

(2015) Ya-Qin Fan et al.   Marine Drugs

Spongionella Secondary Metabolites Protect Mitochondrial Function in Cortical Neurons against Oxidative Stress

(2014) Marta Leirós et al.   Marine Drugs

A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review

(2014) Cristina Torres-Fuentes et al.   NUTRITIONAL NEUROSCIENCE

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release

(2014) John P.M. Finberg   PHARMACOLOGY & THERAPEUTICS

Molecular determinants for nuclear receptors selectivity: Chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists

(2013) Antonio Carrieri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Origins of the β-lactam rings in natural products

(2013) Kapil Tahlan et al.   JOURNAL OF ANTIBIOTICS

Effect on α-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC751

(2013) Rizna Triana Dewi et al.   MEDICINAL CHEMISTRY RESEARCH

Vasodilator Compounds Derived from Plants and Their Mechanisms of Action

(2013) Francisco Luna-Vázquez et al.   MOLECULES

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists

(2012) Giuseppe Fracchiolla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effects of natural antioxidants in neurodegenerative disease

(2012) Sonia Luz Albarracin et al.   NUTRITIONAL NEUROSCIENCE

Nutraceuticals as Ligands of PPARγ

(2012) Meera Penumetcha et al.   PPAR Research

The Pharmacological Treatment and Management of Obesity

(2011) Syed Sufyan Hussain et al.   POSTGRADUATE MEDICINE

Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?

(2010) Alessandro Martorana et al.   CNS Neuroscience & Therapeutics

Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity

(2008) Giuseppe Fracchiolla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Paclitaxel and docetaxel in the treatment of breast cancer

(2008) Emmanouel Saloustros et al.   EXPERT OPINION ON PHARMACOTHERAPY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions

(2008) Nicholas P. Hays et al.   PHARMACOLOGY & THERAPEUTICS