Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator

Biogenesis pathways of α-helical mitochondrial outer membrane proteins

(2020) Layla Drwesh et al.   BIOLOGICAL CHEMISTRY

In Vivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23

(2020) Umut Günsel et al.   JOURNAL OF MOLECULAR BIOLOGY

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

(2020) Srujan Kumar Matta et al.   MOLECULAR BIOLOGY OF THE CELL

Role of the translocase of the mitochondrial inner membrane in the import of tRNAs into mitochondria in Trypanosoma brucei

(2020) Muhammad Younas Khan Barozai et al.   GENE

Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators

(2020) Huy Cuong Tran et al.   MITOCHONDRION

Novel IM‐associated protein Tim54 plays a role in the mitochondrial import of internal signal‐containing proteins in Trypanosoma brucei

(2020) Ujjal K Singha et al.   BIOLOGY OF THE CELL

Structure of the mitochondrial TIM22 complex from yeast

(2020) Yutong Zhang et al.   CELL RESEARCH

Cryo-EM structure of the human mitochondrial translocase TIM22 complex

(2020) Liangbo Qi et al.   CELL RESEARCH

The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor

(2020) Eva Zöller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

(2020) Maria Calvo-Rodriguez et al.   TRENDS IN NEUROSCIENCES

Kinetoplast Division Factors in a Trypanosome

(2019) Kojo Mensa-Wilmot et al.   TRENDS IN PARASITOLOGY

Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis

(2019) Abhijith Makki et al.   PLOS BIOLOGY

Transport of Proteins into Mitochondria

(2019) Katja G. Hansen et al.   PROTEIN JOURNAL

Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity

(2019) Angelica Avagliano et al.   Cells

LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of Breast Cancer Cells

(2019) Xinping Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease

(2019) Matthew J Eramo et al.   JOURNAL OF BIOCHEMISTRY

Plant mitochondrial protein import: the ins and outs

(2018) Abi S. Ghifari et al.   BIOCHEMICAL JOURNAL

Mitochondrial Outer Membrane Channels: Emerging Diversity in Transport Processes

(2018) Thomas Becker et al.   BIOESSAYS

Plant Mitochondrial Inner Membrane Protein Insertion

(2018) Renuka Kolli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

(2018) Joseph T. Smith et al.   mSphere

A Single Tim Translocase In The Mitosomes Of Giardia Intestinalis Illustrates Convergence Of Protein Import Machines In Anaerobic Eukaryotes

(2018) Eva Pyrihová et al.   Genome Biology and Evolution

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

(2018) Alexander Benjamin Schendzielorz et al.   Nature Communications

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space

(2018) Katharina Weinhäupl et al.   CELL

Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?

(2018) André Schneider   PLoS Pathogens

The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei

(2017) Ebony Weems et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Structure and function of complex I in animals and plants - a comparative view

(2017) Jennifer Senkler et al.   PHYSIOLOGIA PLANTARUM

tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes

(2017) Moritz Niemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acylglycerol Kinase: Mitochondrial Protein Transport Meets Lipid Biosynthesis

(2017) Christoph U. Mårtensson et al.   TRENDS IN CELL BIOLOGY

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

(2017) Alena Zíková et al.   PLoS Pathogens

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

(2017) Christoph Wenger et al.   PLoS Pathogens

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

(2017) Keren Demishtein-Zohary et al.   eLife

Mitochondrial protein import - Functional analysis of the highly diverged Tom22 orthologue of Trypanosoma brucei

(2017) Jan Mani et al.   Scientific Reports

Evolution of the Tim17 protein family

(2016) Vojtěch Žárský et al.   Biology Direct

TIM29 is a subunit of the human carrier translocase required for protein transport

(2016) Sylvie Callegari et al.   FEBS LETTERS

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase

(2016) Devanjan Sinha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

(2016) Ajay Ramesh et al.   JOURNAL OF CELL BIOLOGY

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability

(2016) Srujan Kumar Matta et al.   MOLECULAR AND CELLULAR BIOLOGY

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

(2016) Lidia Wrobel et al.   Scientific Reports

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

(2016) Yilin Kang et al.   eLife

Functional Complementation Analyses Reveal that the Single PRAT Family Protein of Trypanosoma brucei Is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae

(2015) Ebony Weems et al.   EUKARYOTIC CELL

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress

(2015) Marjorie Fullerton et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Peeping at TOMs—Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes

(2015) Jan Mani et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Mitochondrial Heat Shock Protein Machinery Hsp70/Hsp40 Is Indispensable for Proper Mitochondrial DNA Maintenance and Replication

(2015) Jiří Týč et al.   mBio

Architecture of the TIM23 Inner Mitochondrial Translocon and Interactions with the Matrix Import Motor

(2014) See-Yeun Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 fromArabidopsis thaliana

(2014) Rashmi Panigrahi et al.   JOURNAL OF MOLECULAR RECOGNITION

Unraveling the Intricate Organization of Mammalian Mitochondrial Presequence Translocases: Existence of Multiple Translocases for Maintenance of Mitochondrial Function

(2014) D. Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages

(2014) S Srivastava et al.   Cell Death & Disease

Lupine embryo axes under salinity stress. II. Mitochondrial proteome response

(2013) Łukasz Wojtyla et al.   ACTA PHYSIOLOGIAE PLANTARUM

Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

(2013) Takashi Makiuchi et al.   BIOCHIMIE

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Folding and Biogenesis of Mitochondrial Small Tim Proteins

(2013) Efrain Ceh-Pavia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TIMMDC1/C3orf1 Functions as a Membrane-Embedded Mitochondrial Complex I Assembly Factor through Association with the MCIA Complex

(2013) Virginia Guarani et al.   MOLECULAR AND CELLULAR BIOLOGY

Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function

(2013) Adinarayana Marada et al.   MOLECULAR BIOLOGY OF THE CELL

Three proteins mediate import of transit sequence-less precursors into the inner envelope of chloroplasts in Arabidopsis thaliana

(2013) C. Rossig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Back to basics: A revealing secondary reduction of the mitochondrial protein import pathway in diverse intracellular parasites

(2012) Eva Heinz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries

(2012) Elisabeth Eckers et al.   BIOLOGICAL CHEMISTRY

Genetic Analysis of Complex Interactions Among Components of the Mitochondrial Import Motor and Translocon in Saccharomyces cerevisiae

(2012) B. A. Schilke et al.   GENETICS

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50 inTrypanosoma bruceiPossesses a Dual Specificity Phosphatase Activity and Is Critical for Mitochondrial Protein Import

(2012) Melanie R. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import

(2012) Sanjana Rao et al.   MOLECULAR BIOLOGY OF THE CELL

Dual Location of the Mitochondrial Preprotein Transporters B14.7 and Tim23-2 in Complex I and the TIM17:23 Complex inArabidopsisLinks Mitochondrial Activity and Biogenesis

(2012) Yan Wang et al.   PLANT CELL

A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways

(2012) V. L. Hewitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial tRNA Import and Its Consequences for Mitochondrial Translation

(2011) André Schneider   Annual Review of Biochemistry

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

(2011) Oliver Schmidt et al.   CELL

Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

(2011) Mascha Pusnik et al.   CURRENT BIOLOGY

In vivo study in Trypanosoma brucei links mitochondrial transfer RNA import to mitochondrial protein import

(2011) Florence Tschopp et al.   EMBO REPORTS

The Core Components of Organelle Biogenesis and Membrane Transport in the Hydrogenosomes of Trichomonas vaginalis

(2011) Petr Rada et al.   PLoS One

On the mechanism of preprotein import by the mitochondrial presequence translocase

(2010) Martin van der Laan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Common ground for protein translocation: access control for mitochondria and chloroplasts

(2010) Enrico Schleiff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High TIMM17A expression is associated with adverse pathological and clinical outcomes in human breast cancer

(2010) Mohamed Salhab et al.   Breast Cancer

The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica

(2010) Pavel Dolezal et al.   PLoS Pathogens

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis

(2009) M. J. Dagley et al.   MOLECULAR BIOLOGY AND EVOLUTION

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

(2008) Natalia Gebert et al.   EMBO REPORTS

The Tim8–Tim13 Complex Has Multiple Substrate Binding Sites and Binds Cooperatively to Tim23

(2008) Kristen N. Beverly et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei

(2008) Ujjal K. Singha et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Structural and Functional Requirements for Activity of the Tim9–Tim10 Complex in Mitochondrial Protein Import

(2008) Michael J. Baker et al.   MOLECULAR BIOLOGY OF THE CELL