期刊
EMBO REPORTS
卷 12, 期 8, 页码 825-832出版社
WILEY
DOI: 10.1038/embor.2011.111
关键词
F1-ATP synthase; mitochondrial protein import; mitochondrial tRNA import; parasitic protozoa
资金
- Swiss National Foundation [3100A0_121937]
Trypanosoma brucei imports all mitochondrial transfer RNAs (tRNAs) from the cytosol. By using cell lines that allow independent tetracycline-inducible RNA interference and isopropyl-beta-D-thiogalactopyranoside-inducible expression of a tagged tRNA, we show that ablation of Tim17 and mitochondrial heat-shock protein 70, components of the inner-membrane protein translocation machinery, strongly inhibits import of newly synthesized tRNAs. These findings, together with previous results in yeast and plants, suggest that the requirement for mitochondrial protein-import factors might be a conserved feature of mitochondrial tRNA import in all systems.
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