Arrested development: suppression of NK cell function in the tumor microenvironment

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

(2020) Christopher E. Rudd et al.   Cell Reports

Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors

(2020) Ombretta Melaiu et al.   Frontiers in Immunology

CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency

(2020) Feng Li et al.   Journal for ImmunoTherapy of Cancer

NK Cell-Based Immunotherapy in Renal Cell Carcinoma

(2020) Iñigo Terrén et al.   Cancers

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

(2020) Jing Ni et al.   IMMUNITY

Combination of monalizumab and cetuximab in recurrent or metastatic head and neck cancer patients previously treated with platinum-based chemotherapy and PD-(L)1 inhibitors.

(2020) Roger B. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells

(2020) Luke Riggan et al.   Cell Reports

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

(2020) Rih-Sheng Huang et al.   Frontiers in Immunology

Overcoming hypoxia-induced functional suppression of NK cells

(2020) Kristen Solocinski et al.   Journal for ImmunoTherapy of Cancer

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

(2020) Huang Zhu et al.   Cell Stem Cell

Drug target validation in primary human natural killer cells using CRISPR RNP

(2020) Jai Rautela et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies

(2020) Tobias Bald et al.   NATURE IMMUNOLOGY

MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

(2020) Srividya Swaminathan et al.   Nature Communications

Targeting NK Cell Checkpoint Receptors or Molecules for Cancer Immunotherapy

(2020) Cai Zhang et al.   Frontiers in Immunology

PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

(2020) Qi Peng et al.   Nature Communications

CAR-NK cells: A promising cellular immunotherapy for cancer

(2020) Guozhu Xie et al.   EBioMedicine

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Natural killer group 2D receptor and its ligands in cancer immune escape

(2019) Shixin Duan et al.   Molecular Cancer

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

(2019) Takahiro Kamiya et al.   JOURNAL OF CLINICAL INVESTIGATION

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors

(2019) Salah-Eddine Bentebibel et al.   Cancer Discovery

An IL-15-based superagonist ALT-803 enhances the NK cell response to cetuximab-treated squamous cell carcinoma of the head and neck

(2019) Ashley Pinette et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

(2019) Xiaofei Zhou et al.   NATURE IMMUNOLOGY

Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment

(2019) Russell K. Pachynski et al.   Frontiers in Immunology

The Natural Cytotoxicity Receptors in Health and Disease

(2019) Alexander David Barrow et al.   Frontiers in Immunology

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

(2019) Claudia Carenza et al.   Frontiers in Immunology

TAM receptors attenuate murine NK‐cell responses via E3 ubiquitin ligase Cbl‐b

(2019) Leilani M. Chirino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

(2019) Shuang Qin et al.   Molecular Cancer

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

(2019) Xiaohu Zheng et al.   NATURE IMMUNOLOGY

The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy

(2019) Haoyu Sun et al.   Frontiers in Immunology

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells

(2019) Mattias Carlsten et al.   Frontiers in Immunology

Impairment of NKG2D-Mediated Tumor Immunity by TGF-β

(2019) Mariya Lazarova et al.   Frontiers in Immunology

PD-1 disrupted CAR-T cells in the treatment of solid tumors: Promises and challenges

(2019) Eileen McGowan et al.   BIOMEDICINE & PHARMACOTHERAPY

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

(2019) Shi Yong Neo et al.   JOURNAL OF CLINICAL INVESTIGATION

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

(2019) David N. Nguyen et al.   NATURE BIOTECHNOLOGY

CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice with Peritoneal Xenografts

(2019) Yu Yang Ng et al.   Molecular Therapy-Oncolytics

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

(2018) Alexander D. Barrow et al.   CELL

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

(2018) Jingjing Cong et al.   Cell Metabolism

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells

(2018) Akiko Seki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial

(2018) John M Wrangle et al.   LANCET ONCOLOGY

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

(2018) Carsten Denkert et al.   LANCET ONCOLOGY

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

(2018) Róisín M. Loftus et al.   Nature Communications

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

(2018) Katharina Helene Susek et al.   Frontiers in Immunology

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

(2018) Brian W. Labadie et al.   CLINICAL CANCER RESEARCH

High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

(2018) Adeline Crinier et al.   IMMUNITY

Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis

(2018) Cathal Harmon et al.   Cancer Immunology Research

Adenosinergic Signaling Alters Natural Killer Cell Functional Responses

(2018) Andrea M. Chambers et al.   Frontiers in Immunology

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

(2017) Zachary B. Davis et al.   SEMINARS IN IMMUNOLOGY

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells

(2017) Stefano Regis et al.   Frontiers in Immunology

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

(2017) Eva M. Putz et al.   OncoImmunology

Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma

(2017) Veronika Kremer et al.   Journal for ImmunoTherapy of Cancer

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

(2017) Deborah Charych et al.   PLoS One

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Toxicities of chimeric antigen receptor T cells: recognition and management

(2016) Jennifer N. Brudno et al.   BLOOD

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities

(2016) Sonia Y. Velásquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CIS is a potent checkpoint in NK cell–mediated tumor immunity

(2016) Rebecca B Delconte et al.   NATURE IMMUNOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

(2016) Rizwan Romee et al.   Science Translational Medicine

Repression of GSK3 restores NK cell cytotoxicity in AML patients

(2016) Reshmi Parameswaran et al.   Nature Communications

T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells

(2016) E. Zah et al.   Cancer Immunology Research

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor

(2016) Silvia Pesce et al.   Frontiers in Immunology

Human Circulating and Tissue-Resident CD56bright Natural Killer Cell Populations

(2016) Janine E. Melsen et al.   Frontiers in Immunology

Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells

(2016) Sourav Paul et al.   OncoImmunology

The breast tumor microenvironment alters the phenotype and function of natural killer cells

(2015) Tamara Krneta et al.   Cellular & Molecular Immunology

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Characterization of tumor infiltrating natural killer cell subset

(2015) Inbar Levi et al.   Oncotarget

Chemokine Receptor Expression on Normal Blood CD56+NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population

(2015) Margarida Lima et al.   Journal of Immunology Research

TGF-  Utilizes SMAD3 to Inhibit CD16-Mediated IFN-  Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

(2014) R. Trotta et al.   JOURNAL OF IMMUNOLOGY

CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph

(2014) P. Carrega et al.   JOURNAL OF IMMUNOLOGY

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Interleukin-17D Mediates Tumor Rejection through Recruitment of Natural Killer Cells

(2014) Timothy O’Sullivan et al.   Cell Reports

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Neuroblastoma-Derived TGF- 1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells

(2013) R. Castriconi et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

(2013) Subhashis Sarkar et al.   PLoS One

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow

(2013) Giovanni Bernardini et al.   Frontiers in Immunology

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis

(2013) Xinrong Ma et al.   OncoImmunology

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

(2012) Timothy O’Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

(2012) Gregory L. Moore et al.   mAbs

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking

(2011) K. Mayol et al.   BLOOD

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

(2011) Dawn Holt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Establishment, Characterization, and Successful Adaptive Therapy against Human Tumors of NKG Cell, a New Human NK Cell Line

(2011) Min Cheng et al.   CELL TRANSPLANTATION

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Immunoediting of the NK Group 2D Ligand H60a

(2011) T. O'Sullivan et al.   JOURNAL OF IMMUNOLOGY

TGF-  downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

(2011) C. A. Crane et al.   NEURO-ONCOLOGY

Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population

(2010) Nicole Marquardt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase

(2010) Hun Sik Kim et al.   IMMUNITY

Activating and inhibitory receptors of natural killer cells

(2010) Hollie J Pegram et al.   IMMUNOLOGY AND CELL BIOLOGY

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

(2009) H. Fujisaki et al.   CANCER RESEARCH

Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells

(2008) Paolo Carrega et al.   CANCER

Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-  and CXCR3 Ligands

(2008) M. Wendel et al.   CANCER RESEARCH

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY