Article
Oncology
Rupen Desai, Andrew T. Coxon, Gavin P. Dunn
Summary: This article provides an overview of the importance of the immune system in cancer therapy, discussing the immunoediting hypothesis and the development and application of immunotherapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemical Research Methods
Xiaoming Zhong, Hongqun Liao, Shaowen Hu, Kaiyuan Luo, Huifang Zhu
Summary: The natural product adenanthin significantly promotes the expression of NKG2D ligands in hepatoma cells, improving the killing activity of NK cells against liver cancer cells. This study is the first to report the anti-cancer effects of adenanthin mediated by indirect activation of NK cells. Adenanthin may be used as a sensitizing agent for NK cells in tumor immunotherapy.
MOLECULAR AND CELLULAR PROBES
(2021)
Review
Pharmacology & Pharmacy
Yarong Zhao, Luotong Liu, Rongze Sun, Guilin Cui, Shuyu Guo, Songren Han, Ziwei Li, Tian Bai, Lesheng Teng
Summary: As an important means of communication among cells, exosomes are increasingly studied, especially in the context of cancer immunotherapy. Exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions due to carrying different proteins and nucleic acids from the source cells. Based on the role of exosomes in intercellular communication, cancer treatment methods are continuously being researched. This review briefly introduces the molecular composition of exosomes and its secretion mechanism, summarizes the role of exosomes encapsulating different information molecules, and provides a detailed introduction to the role of exosomes in the three phases of tumor immunoediting and the relevant literature of exosomes in the tumor immune microenvironment.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Editorial Material
Oncology
Miriam Ferrer, Tobias Janowitz
Summary: This study found that low-intensity exercise can improve tumor control and response to immunotherapy in an orthotopic pancreatic cancer model, and combination therapy significantly reduces tumor growth.
Review
Cell Biology
Theodora Katopodi, Savvas Petanidis, Charalampos Charalampidis, Ioanna Chatziprodromidou, Panagiotis Eskitzis, Drosos Tsavlis, Paul Zarogoulidis, Christoforos Kosmidis, Dimitris Matthaios, Konstantinos Porpodis
Summary: The tumor microenvironment, particularly the dendritic cells (DCs), plays a crucial role in tumor progression, metastasis, and immunosuppression. This review examines the function of tumor-infiltrating DCs in immune cell signaling pathways, treatment resistance, tumor recurrence, and immunosuppression. Special emphasis is given to DC metabolism, differentiation, and plasticity, as well as the interaction between myeloid cells and DCs in tumor-related immunosuppression. The article also discusses the molecular immune-related mechanisms in the tumor microenvironment that lead to reduced drug sensitivity and tumor relapse, and explores innovative approaches for therapeutic modulation of immunosuppressive DCs.
Review
Immunology
Kari A. Shaver, Tayler J. Croom-Perez, Alicja J. Copik
Summary: This review highlights the crucial role of NK cells in cancer immunotherapy, emphasizing their importance in priming the immune system, activating the adaptive immune response, and improving treatment success rates. However, compromised NK cell immunity in many patients reduces the likelihood of successful outcomes from immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xin Chen, Lei Jiang, Xuesong Liu
Summary: This review discusses the contributions of natural killer (NK) cells in cancer treatment, explores the current strategies at harnessing NK cells for cancer treatment, and highlights the importance of NK cell-mediated therapies in the next wave of cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark Samuels, Georgios Giamas
Summary: Breast cancer immunotherapy, as an active field of research over the past 50 years, has shown great potential in improving survival rates for patients. Researchers are exploring how breast cancer evades immune destruction and developing new treatment options such as cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natasa Todorovic-Rakovic
Summary: The evolution of malignant cells is driven by the increasing oncogenic fitness in active interaction with the tumor microenvironment. Mechanisms promoting the adaptive evolution of cancer cells involve clonal selection and selective pressure from host defensive strategies. The immune system, as part of host defense mechanisms, plays a crucial role in modulating cancer evolution and progression.
Article
Nanoscience & Nanotechnology
Ashley R. Hoover, Kaili Liu, Wei R. Chen
Summary: The combination of nanotechnology, photonics, and immunotherapy has the potential to significantly impact the field of cancer treatment by synergizing to regulate immune editing and the immune system. By combining different treatment modalities, it can provide long-term tumor-specific immunity, preventing tumor metastasis and recurrence.
Review
Chemistry, Multidisciplinary
Shan Gao, Xiaoye Yang, Jiangkang Xu, Na Qiu, Guangxi Zhai
Summary: Immunotherapy utilizing the human immune system against cancer has become a mainstream strategy, with the potential to eliminate tumors and treat metastasis and recurrence. The development of nanotechnology has enabled the application of nanomaterials in cancer immunotherapy, offering significant potential for improving treatment efficacy. Nanotechnology-based immunotherapy aims to produce effective anti-tumor immune responses and enhance tumor immune defense by modulating the immune suppression mechanism in the tumor microenvironment.
Article
Oncology
Constantin N. Baxevanis, Maria Goulielmaki, Maria Adamaki, Sotirios P. Fortis
Summary: The cancer immunoediting theory explains the role of endogenous antitumor immunity in shaping tumor development and the potential for targeted therapies based on tumor-specific neoantigens.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Immunology
Carmen Mestre-Duran, Carla Martin-Cortazar, Blanca Garcia-Solis, Alicia Pernas, Lidia Pertinez, Victor Galan, Luisa Sisinni, Laura Clares-Villa, Alfonso Navarro-Zapata, Karima Al-Akioui, Adela Escudero, Cristina Ferreras, Antonio Perez-Martinez
Summary: Natural killer (NK) cells, as part of the innate immune system, play a vital role in defending against infected and transformed cells. The balance between inhibitory and activating receptors on NK cells controls their cytotoxic capability. The JAK/STAT pathway and Toll-like receptors (TLRs) are key factors in NK cell activation and response to pathogens. Ruxolitinib, a JAK1/2 inhibitor, has shown moderate effects on TLR pathway activation and cytokine production in NK cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Siavash Rajabpour, Alexander Vera, Wen He, Benjamin N. Katz, Roland J. Koch, Margaux Lassauniere, Xuegang Chen, Cequn Li, Katharina Nisi, Hesham El-Sherif, Maxwell T. Wetherington, Chengye Dong, Aaron Bostwick, Chris Jozwiak, Adri C. T. van Duin, Nabil Bassim, Jun Zhu, Gwo-Ching Wang, Ursula Wurstbauer, Eli Rotenberg, Vincent Crespi, Su Ying Quek, Joshua A. Robinson
Summary: Controllably tuning the electronic, superconducting, and optical properties of 2D metals can be achieved through the formation of alloys. Environmentally robust large-area 2D-InxGa1-x alloys with adjustable composition show a direct correlation between optical and electronic properties.
ADVANCED MATERIALS
(2021)
Review
Mathematics, Interdisciplinary Applications
Manuel Arturo Nova Martinez, Hector Andres Granada Diaz, Pablo Emilio Calderon Saavedra
Summary: This article investigates the dynamics of cancer using a coupled system of three nonlinear ordinary differential equations. The study examines the evolution of the cancer tumor and determines the values of the immune cell activation parameter that cause changes in this evolution. The analysis reveals the range of immune cell activation that leads to tumor escape, tumor latency, or oscillatory behavior.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2022)
Editorial Material
Oncology
Robert D. Schreiber, Philip D. Greenberg
Summary: Looking back at 2021, the challenges brought by the COVID-19 pandemic highlighted the importance of scientific research and collaboration. Cancer Immunology Research plays a central role in this rapidly growing field. The Journal received a record number of original research articles and achieved a high Impact Factor in 2021. The success of Cancer Immunology Research is attributed to the hard work of many individuals, including editors, reviewers, and researchers. The Journal remains committed to publishing innovative research and advancing cancer immunology and immunotherapy education.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Yu Xia, Katalin Sandor, Joy A. Pai, Bence Daniel, Saravanan Raju, Renee Wu, Sunnie Hsiung, Yanyan Qi, Tenzin Yangdon, Mariko Okamoto, Chun Chou, Kamir J. Hiam-Galvez, Robert D. Schreiber, Kenneth M. Murphy, Ansuman T. Satpathy, Takeshi Egawa
Summary: The study reveals the heterogeneity and plasticity of CD4(+) T cells during chronic infection and tumor response, and highlights their population dynamics through a stable, bipotent intermediate state.
Article
Oncology
Stephen T. Ferris, Ray A. Ohara, Feiya Ou, Renee Wu, Xiao Huang, Sunkyung Kim, Jing Chen, Tian-Tian Liu, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy
Summary: It has been found that dendritic cells (DC) do not directly activate tumor-specific T cells, but induce anti-tumor immune responses by transferring their antigens to host DCs. Type 1 conventional DCs (cDC1) are more effective than GMDC as cancer vaccines. Vaccination with cDC1 can activate tumor-specific CD8+ T cells and lead to tumor rejection.
CANCER IMMUNOLOGY RESEARCH
(2022)
Editorial Material
Oncology
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Editorial Material
Oncology
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
CANCER PREVENTION RESEARCH
(2022)
Editorial Material
Oncology
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Editorial Material
Oncology
Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Benjamin Kraemer, Ansel P. Nalin, Feiyan Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M. Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hoelzel, Robert Hueneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J. Kaczmarek, Brooke Benner, Matthew R. Lordo, Jesse Kowalski, Adam Gerhardt, Joerg Timm, Marieta Toma, Raphael Mohr, Andreas Tuerler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T. Abdallah, Christian P. Strassburg, Ulrich Spengler, William E. Carson III, Bethany L. Mundy-Bosse, Matteo Pellegrini, Timothy E. O'Sullivan, Aharon G. Freud, Jacob Nattermann
Summary: We identified a distinct population of liver-type ILC1s with unique transcriptional, phenotypic, and functional features, different from other known ILC1 subsets. These liver-type ILC1s express CD49a+CD94+CD200R1+ and the transcription factor T-BET, but not the activating receptor NKp80 or the transcription factor EOMES. Similar to NK cells, liver-type ILC1s produce IFN-g, TNF-a, and GM-CSF, but they also produce IL-2 and lack perforin and granzyme-B. These cells can be expanded in cirrhotic liver tissues and can be generated in vitro from blood-derived ILC precursors in the presence of TGF-b1 and liver sinusoidal endothelial cells. Cells with similar characteristics can also be found in tonsil and intestinal tissues. In conclusion, our study identifies and classifies a population of human cross-tissue ILC1s.
Article
Immunology
Iona S. Schuster, Xavier Y. X. Sng, Colleen M. Lau, David R. Powell, Orr-El Weizman, Joseph C. Sun, Peter Fleming, Georgia E. G. Neate, Valentina Voigt, Sam Sheppard, Andreas I. Maraskovsky, Sheridan Daly, Motoko Koyama, Geoffrey R. Hill, Stephen J. Turner, Timothy E. O'Sullivan, Christopher E. Andoniou, Mariapia A. Degli-Esposti
Summary: Tissue health relies on the ability to respond to disturbances and restore homeostasis. This study identifies a population of innate lymphocytes, called tissue-resident memory-like natural killer (NKRM) cells, that develop adaptive-like features including long-term residency in non-lymphoid tissues. These NKRM cells prevent autoimmunity by eliminating CD4+ T cells, and modulating their functions could offer new strategies for treating inflammatory and autoimmune diseases.
Article
Immunology
Mandy I. Cheng, Joey H. Li, Luke Riggan, Bryan Chen, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O'Sullivan, Maureen A. Su
Summary: The outcomes of viral infections are influenced by sex, with males being more susceptible. Surprisingly, males have increased numbers of antiviral natural killer (NK) cells. However, these NK cells in males display decreased effector function compared to females in both mice and humans. The differences are not solely dependent on gonadal hormones and are associated with lower levels of UTX, an epigenetic regulator, in male NK cells. On the other hand, NK cell-intrinsic UTX deficiency in female mice increases NK cell numbers and reduces effector responses, leading to increased lethality to mouse cytomegalovirus.
Article
Cell Biology
Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, Timothy E. O'Sullivan
Summary: Using single-cell transcriptomic analysis, the study reveals the liver-resident cell connectome and signalome during acute liver injury. The results identify Il12b as a central regulator of liver injury-associated changes in gene expression. It is found that Interleukin (IL)-12 produced by conventional type 1 dendritic cells (cDC1s) is required for protection during acute injury through activation of interferon (IFN)-g production by liver-resident type 1 innate lymphoid cells (ILC1s). The study also uncovers the role of cDC1-intrinsic cGAS-STING signaling in initiating early protective immune responses via IL-12 production.
Article
Endocrinology & Metabolism
Andrew D. Hildreth, Eddie T. Padilla, Meha Gupta, Yung Yu Wong, Ryan Sun, Akshara R. Legala, Timothy E. O'Sullivan
Summary: This study reveals that conventional type 1 dendritic cells (cDC1s) in white adipose tissue (WAT) take up DNA-containing apoptotic bodies from adipocytes, which triggers STING-dependent interleukin-12 production from cDC1s, contributing to WAT inflammation in mice.
Meeting Abstract
Immunology
Yu Xia, Katalin Sandor, Joy A. Pai, Bence Daniel, Saravanan Raju, Renee Wu, Sunnie Hsiung, Yanyan Qi, Tenzin Yangdon, Mariko Okamoto, Robert D. Schreiber, Kenneth M. Murphy, Ansuman Satpathy, Takeshi Egawa
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Mandy I. Cheng, Luke Riggan, Feiyang Ma, Scott Chin, Rana Tafti, Matteo Pellegrini, Timothy E. O'Sullivan, Maureen A. Su
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
Koral Shah, Aravinda Ganapathy, Ariel Borkowski, Nakul Shah, Dhruv Bansal, Rachel Beck, Eric Marshall Knoche, Joel Picus, Melissa Andrea Reimers, Bruce J. Roth, James L. Gulley, Robert Schreiber, Russell Kent Pachynski
JOURNAL OF CLINICAL ONCOLOGY
(2022)