The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
出版年份 2021 全文链接
标题
The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
作者
关键词
-
出版物
Frontiers in Oncology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-01-11
DOI
10.3389/fonc.2020.583217
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mitochondrial TCA cycle metabolites control physiology and disease
- (2020) Inmaculada Martínez-Reyes et al. Nature Communications
- PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling
- (2020) Michelle K. Y. Siu et al. Oncogenesis
- STAT 3 ‐dependent analysis reveals PDK 4 as independent predictor of recurrence in prostate cancer
- (2020) Monika Oberhuber et al. Molecular Systems Biology
- Micromanaging aerobic respiration and glycolysis in cancer cells
- (2019) Ayla V. Orang et al. Molecular Metabolism
- Serum pyruvate dehydrogenase kinase as a prognostic marker for cholangiocarcinoma
- (2019) Surangkana Sanmai et al. Oncology Letters
- PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia
- (2019) Fabrizio Pin et al. FASEB JOURNAL
- High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases
- (2019) Moritz J. Strowitzki et al. BRITISH JOURNAL OF CANCER
- Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation
- (2019) Ya‐Nan Xue et al. Cancer Medicine
- MicroRNA‐214 suppresses cell proliferation and migration and cell metabolism by targeting PDK2 and PHF6 in hepatocellular carcinoma
- (2019) Qiangfeng Yu et al. CELL BIOLOGY INTERNATIONAL
- miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3
- (2019) Lan Feng et al. BIOSCIENCE REPORTS
- Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
- (2019) Benjamin L. Woolbright et al. MOLECULAR CANCER THERAPEUTICS
- The Role of Glutaminase in Cancer
- (2019) Brendah K. Masisi et al. HISTOPATHOLOGY
- Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway
- (2019) Yu Liang et al. ONCOGENE
- Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
- (2019) Tiziana Tataranni et al. Oxidative Medicine and Cellular Longevity
- The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer
- (2019) Wenjuan Qin et al. Scientific Reports
- Benzyl butyl phthalate (BBP) triggers the malignancy of acute myeloid leukemia cells via upregulation of PDK4
- (2019) Xian-Liang Duan et al. TOXICOLOGY IN VITRO
- Loss of PDK4 switches the hepatic NF-κB/TNF pathway from pro-survival to pro-apoptosis
- (2018) Jianguo Wu et al. HEPATOLOGY
- The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance
- (2018) Benjamin L Woolbright et al. MOLECULAR CANCER THERAPEUTICS
- Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
- (2018) Jingjing Chen et al. NATURE GENETICS
- Interacting Cancer Machineries: Cell Signaling, Lipid Metabolism, and Epigenetics
- (2018) Thomas W. Grunt TRENDS IN ENDOCRINOLOGY AND METABOLISM
- MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer
- (2018) Zhongyuan He et al. Cell Death & Disease
- Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression
- (2018) Leena Latonen et al. Nature Communications
- PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
- (2018) Bo-Yoon Park et al. DIABETES
- Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation
- (2018) Meng Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Discovery of potent pyruvate dehydrogenase kinases inhibitors and their anti-lung cancer activity evaluation under hypoxia
- (2018) Ronghua Yang et al. MedChemComm
- Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia
- (2018) Longzhen Cui et al. CANCER GENE THERAPY
- Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex
- (2018) Alla Klyuyeva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
- (2018) Giorgia Zadra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer
- (2018) Jinghao Wang et al. Cancer Management and Research
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
- (2017) F Peng et al. ONCOGENE
- Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxel-resistant human lung cancer cells to paclitaxel
- (2017) Hong Sun et al. Oncotarget
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Glucose Metabolism in the Progression of Prostate Cancer
- (2017) Francesca Cutruzzolà et al. Frontiers in Physiology
- The Metabolic Phenotype of Prostate Cancer
- (2017) Eric Eidelman et al. Frontiers in Oncology
- The Warburg effect and drug resistance
- (2016) Bhaskar Bhattacharya et al. BRITISH JOURNAL OF PHARMACOLOGY
- Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer
- (2016) Jong-Lyel Roh et al. CANCER LETTERS
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins
- (2016) Jonathan Choiniere et al. MOLECULAR PHARMACOLOGY
- The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis
- (2016) G Li et al. ONCOGENE
- PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer
- (2016) Tao Liu et al. ONCOLOGY REPORTS
- KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis
- (2016) Ling-Yu Wang et al. Cell Reports
- PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
- (2015) Fanny Dupuy et al. Cell Metabolism
- Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
- (2015) Wen Zhang et al. International Journal of Biological Sciences
- The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents
- (2015) Elise Saunier et al. INTERNATIONAL JOURNAL OF CANCER
- Dysregulated metabolism contributes to oncogenesis
- (2015) Matthew D. Hirschey et al. SEMINARS IN CANCER BIOLOGY
- Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- (2015) Lijun Qin et al. Oncotarget
- Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells
- (2015) William Walter et al. SpringerPlus
- PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade
- (2014) Zhibo Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth
- (2014) Changliang Shan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex
- (2014) Jun Fan et al. MOLECULAR CELL
- The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
- (2014) Shuai Zhang et al. Nutrition & Metabolism
- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
- (2014) In-Kyu Lee Diabetes & Metabolism Journal
- Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
- (2013) S.-M. Fendt et al. CANCER RESEARCH
- Regulation of pyruvate metabolism and human disease
- (2013) Lawrence R. Gray et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
- (2013) Yi Xuan et al. EXPERIMENTAL CELL RESEARCH
- Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes
- (2013) Rongya Tao et al. PLoS One
- Inactivation of the HIF-1 /PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
- (2012) J. Kluza et al. CANCER RESEARCH
- Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target
- (2012) HOON HUR et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle
- (2011) L. Wang et al. Acta Physiologica
- Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer
- (2011) Chun-Wun Lu et al. AMERICAN JOURNAL OF PATHOLOGY
- p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2
- (2011) T. Contractor et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
- (2011) Taro Hitosugi et al. MOLECULAR CELL
- Mitochondrial Mutations Contribute to HIF1 Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma
- (2009) W. Sun et al. CLINICAL CANCER RESEARCH
- Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin
- (2009) Sara Connaughton et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
- (2008) S M Wigfield et al. BRITISH JOURNAL OF CANCER
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells
- (2008) Thomas McFate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance
- (2008) Chun-Wun Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search