Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells

(2015) Cinzia Franchin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Case 1-2015

(2015) Beverly Moy et al.   NEW ENGLAND JOURNAL OF MEDICINE

ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65

(2015) Min-Young Kim et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels

(2014) Nishi Srivastava et al.   Cell Metabolism

Association of the Breast Cancer Antiestrogen Resistance Protein 1 (BCAR1) and BCAR3 Scaffolding Proteins in Cell Signaling and Antiestrogen Resistance

(2014) Yann Wallez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade

(2014) Zhibo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma

(2014) Rika Fujii et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

(2014) Ayesha N Shajahan-Haq et al.   Molecular Cancer

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

(2014) Yoonjin Lee et al.   NATURE

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Extended adjuvant endocrine therapy in hormone-receptor positive breast cancer

(2013) Kathrin Strasser-Weippl et al.   BREAST

Tamoxifen resistance: From bench to bedside

(2013) Marjolein Droog et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acquired Resistance to Tamoxifen Is Associated with Loss of the Type I Insulin-like Growth Factor Receptor: Implications for Breast Cancer Treatment

(2012) D. H. Fagan et al.   CANCER RESEARCH

Sequence analysis of mutations and translocations across breast cancer subtypes

(2012) Shantanu Banerji et al.   NATURE

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ

(2012) Ja Hee Lee et al.   PLoS One

The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle

(2011) L. Wang et al.   Acta Physiologica

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

(2011) Cody C. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A non-functional retinoblastoma tumor suppressor (RB) pathway in premenopausal breast cancer is associated with resistance to tamoxifen

(2011) Sophie Lehn et al.   CELL CYCLE

A Gene Expression Signature from Human Breast Cancer Cells with Acquired Hormone Independence Identifies MYC as a Mediator of Antiestrogen Resistance

(2011) T. W. Miller et al.   CLINICAL CANCER RESEARCH

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance

(2010) Andrew Skildum et al.   BREAST CANCER RESEARCH AND TREATMENT

Molecular Mechanism and Clinical Implications of Endocrine Therapy Resistance in Breast Cancer

(2010) Grazia Arpino et al.   ONCOLOGY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

(2008) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY