Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

TUBB Variants Underlying Different Phenotypes Result in Altered Vesicle Trafficking and Microtubule Dynamics

(2020) Antonella Sferra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Distribution patterns of tau pathology in progressive supranuclear palsy

(2020) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

(2020) Nadine Ait-Bouziad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

Tau immunotherapies: Lessons learned, current status and future considerations

(2020) L.A. Sandusky-Beltran et al.   NEUROPHARMACOLOGY

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Astrocyte Senescence and Alzheimer’s Disease: A Review

(2020) Xiaojuan Han et al.   Frontiers in Aging Neuroscience

Phosphorylated tau interactome in the human Alzheimer’s disease brain

(2020) Eleanor Drummond et al.   BRAIN

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fyn Kinase Controls Tau Aggregation In Vivo

(2020) Adam Briner et al.   Cell Reports

The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging

(2020) Francisco Muñoz-Carvajal et al.   Frontiers in Aging Neuroscience

Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain

(2020) David F. Wilson et al.   Frontiers in Physiology

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

A Metabolomic study of hibernating Syrian hamster brain: in search of neuroprotective agents

(2019) Carolina Gonzalez-Riano et al.   JOURNAL OF PROTEOME RESEARCH

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

(2019) Erin E. Congdon et al.   EBioMedicine

Dural lymphatics regulate clearance of extracellular tau from the CNS

(2019) Tirth K. Patel et al.   Molecular Neurodegeneration

Tau modulates Schwann cell proliferation, migration and differentiation following peripheral nerve injury

(2019) Sheng Yi et al.   JOURNAL OF CELL SCIENCE

Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor

(2019) Marco Luppi et al.   Frontiers in Neuroanatomy

Tau Phosphorylation and Aggregation in the Developing Human Brain

(2019) Marco M Hefti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

Tau Secretion: Good and Bad for Neurons

(2019) Camille Pernègre et al.   Frontiers in Neuroscience

Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy

(2019) Marianna Alves et al.   Frontiers in Aging Neuroscience

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome

(2019) Richard M. Tsai et al.   JAMA Neurology

Brain inflammatory cytokines and microglia morphology changes throughout hibernation phases in Syrian hamster

(2018) V. Cogut et al.   BRAIN BEHAVIOR AND IMMUNITY

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Recent developments with tau-based drug discovery

(2018) Khalid Iqbal et al.   Expert Opinion on Drug Discovery

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Phosphorylation of different tau sites during progression of Alzheimer’s disease

(2018) Joerg Neddens et al.   Acta Neuropathologica Communications

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction

(2018) Limor Raz et al.   NEUROBIOLOGY OF DISEASE

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

(2018) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development

(2017) Dilina Tuerde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead

(2017) Kai-Hei Tse et al.   JOURNAL OF NEUROCHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Decrease of Protein Phosphatase 2A and its Association with Accumulation and Hyperphosphorylation of Tau in Down Syndrome

(2017) Zhihou Liang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology

(2016) Helen Ling et al.   BRAIN

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Stability properties of neuronal microtubules

(2016) Peter W. Baas et al.   Cytoskeleton

Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons

(2016) Hai-Hong Wang et al.   MOLECULAR NEUROBIOLOGY

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Deep clinical and neuropathological phenotyping of Pick disease

(2015) David J. Irwin et al.   ANNALS OF NEUROLOGY

Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters

(2015) Torsten Bullmann et al.   HIPPOCAMPUS

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Changes in the Golgi Apparatus of Neocortical and Hippocampal Neurons in the Hibernating Hamster

(2015) Alejandro Antón-Fernández et al.   Frontiers in Neuroanatomy

Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer’s disease pathology

(2014) Thomas Arendt et al.   JOURNAL OF NEURAL TRANSMISSION

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

(2013) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

Hibernation

(2013) Fritz Geiser   CURRENT BIOLOGY

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Neuroprotection: Lessons from hibernators

(2012) Kunjan R. Dave et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Human fetal tau protein isoform: Possibilities for Alzheimer's disease treatment

(2012) Nataša Jovanov-Milošević et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Development and Plasticity of the Primary Visual Cortex

(2012) J. Sebastian Espinosa et al.   NEURON

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Pathogenesis of the Tauopathies

(2011) Michel Goedert et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Corticobasal degeneration: a pathologically distinct 4R tauopathy

(2011) Naomi Kouri et al.   Nature Reviews Neurology

The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Hibernation

(2011) Jens T. Stieler et al.   PLoS One

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

From brain formation to plasticity: Insights on Otx2 homeoprotein

(2010) Sayaka Sugiyama et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Pattern of tau isoforms expression during development in vivo

(2009) Torsten Bullmann et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation

(2009) Jens Thorsten Stieler et al.   JOURNAL OF NEURAL TRANSMISSION

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Physiological regulation of tau phosphorylation during hibernation

(2008) Bo Su et al.   JOURNAL OF NEUROCHEMISTRY

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats

(2008) Selina Wray et al.   JOURNAL OF NEUROCHEMISTRY

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A B  Subunit Expression That Correlate with Enhanced Tau Phosphorylation

(2008) J.-M. Sontag et al.   JOURNAL OF NEUROSCIENCE