Article
Veterinary Sciences
Tianmei Qian, Pingping Qiao, Yingnan Lu, Hongkui Wang
Summary: The study revealed a potential role of SS18L1 in peripheral nerve injury, showing its influence on nerve recovery process by regulating Schwann cells proliferation, migration, and differentiation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Neurosciences
Shiying Li, Wenshuang Wu, Jing Zhang, Yu Chen, Yumeng Wu, Xinghui Wang
Summary: The study showed that miR-195-5p is dysregulated after peripheral nerve injury and plays a critical regulatory role in Schwann cell viability, proliferation, and migration. It also affects peripheral nerve regeneration by targeting the Crebl2 gene and modulating Schwann cell functions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yaxian Wang, Fuchao Zhang, Yunsong Zhang, Qi Shan, Wei Liu, Fengyuan Zhang, Feiyu Zhang, Sheng Yi
Summary: Research findings indicate that Btc plays essential roles in regulating Schwann cell migration and axon elongation, suggesting the potential application of Btc as a regenerative strategy for treating peripheral nerve injury.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Anton Borger, Sarah Stadlmayr, Maximilian Haertinger, Lorenz Semmler, Paul Supper, Flavia Millesi, Christine Radtke
Summary: miRNAs play a crucial role in peripheral nerve injuries by regulating specific pathways and proteins, which is essential for understanding the molecular mechanisms of nerve regeneration and providing targets for precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Panjian Lu, Gang Wang, Xiaoheng Lu, Pingping Qiao, Yifei Jin, Jun Yu, Qi Chen, Hongkui Wang
Summary: Matrix metalloproteinase 9 (MMP9) is an important gene up-regulated during peripheral nerve regeneration, and it plays a significant role in Schwann cell migration and phenotype modulation. The direct application of MMP9 recombinant protein enhances the regeneration process in injured rats by promoting Schwann cell migration, blood vessel formation, axon elongation, and myelin wrapping. MMP9 regulates both the extracellular and intracellular metabolism of Schwann cells.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Tian-Kun Hui, Xin-Sheng Lai, Xia Dong, Hongyang Jing, Ziyang Liu, Erkang Fei, Wen-Bing Chen, Shunqi Wang, Dongyan Ren, Suqi Zou, Hai-Tao Wu, Bing-Xing Pan
Summary: Schwann cells play a crucial role in peripheral nerve regeneration, while the conditional knockout of Lrp4 in SCs contributes to enhanced nerve regeneration by promoting SC proliferation and myelin debris clearance. These results suggest a novel role for Lrp4 in peripheral nerve recovery and provide a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Sailing Chen, Qianqian Chen, Xiaojiao Zhang, Yinying Shen, Xinyu Shi, Xiu Dai, Sheng Yi
Summary: Peripheral nerves have limited ability to regenerate after injury. The growth factor amphiregulin (AREG) is upregulated in Schwann cells of injured sciatic nerves and stimulates their proliferation and migration. Schwann cell-secreted AREG promotes neurite outgrowth and axon elongation. Administering AREG to injured nerves facilitates Schwann cell proliferation, cord formation, and axon regrowth. Overall, our study identifies AREG as an important neurotrophic factor and offers a promising therapeutic approach for peripheral nerve injuries.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Mar Bosch-Queralt, Robert Fledrich, Ruth M. Stassart
Summary: The Schwann cell (SC), a glial cell in the peripheral nervous system (PNS), is highly versatile in its functions. It plays a crucial role in ensuring the survival of neurons and guiding their axonal development. SCs also contribute to the structural organization of nerves, including blood vessels and various layers. They are involved in myelination of large axons and organization of non-myelinating bundles. SCs have diverse specialized functions in specific locations, such as the neuromuscular junction and cutaneous sensory end organs. They also interact closely with sensory and autonomic neurons. In response to nerve injuries, SCs exhibit remarkable plasticity and transform into repair cells that promote nerve regeneration. However, the molecular mechanisms underlying these functions are still not fully understood.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Haley Jeanette, Leandro N. Marziali, Urja Bhatia, Abigail Hellman, Jacob Herron, Ashley M. Kopec, Maria Laura Feltri, Yannick Poitelon, Sophie Belin
Summary: YAP and TAZ, effectors of the Hippo pathway, play a regulatory role in the proliferation and differentiation of repair Schwann cells during peripheral nerve regeneration, contributing to remyelination over time.
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Qing Min, David B. Parkinson, Xin-Peng Dun
Summary: Schwann cells in the peripheral nervous system have the ability to promote repair of various tissues, including nerve gaps, skin wounds, digit tips, and tooth regeneration. They are highly motile, secrete signaling molecules, attract macrophages, support neuronal survival, promote axonal regrowth, and interact with other cell types in the regeneration process. The migration of Schwann cells is essential for successful tissue repair, especially in cases of peripheral nerve transection injuries where the cells form cords to guide axon regeneration. Understanding the molecular mechanisms of Schwann cell migration may lead to new therapeutic strategies for peripheral nerve repair.
Review
Neurosciences
Sophie Charlotte Rhode, Justus Patrick Beier, Tim Ruhl
Summary: After peripheral nerve injury, Schwann cells play a crucial role in promoting nerve regeneration, with adipose tissue stem cells being a potential alternative for tissue reconstruction. These stem cells have the ability to differentiate into various cell types and secrete neurotrophic factors that support nerve growth.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Jue Ling, Chang He, Shuxuan Zhang, Yahong Zhao, Meifeng Zhu, Xiaoxuan Tang, Qiaoyuan Li, Liming Xu, Yumin Yang
Summary: This article provides an overview of evaluation methods used to study scaffold-based therapies for peripheral nerve injury (PNI) in experimental animal models, with particular focus on Schwann cell functions and axonal growth within the regenerated nerve.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Jingmin Liu, Xinrui Ma, Xiaofang Hu, Jinkun Wen, Haowen Zhang, Jiawei Xu, Ye He, Xianghai Wang, Jiasong Guo
Summary: Our study found that RhoA knockdown or inhibition can alleviate the proliferation, migration, and differentiation of Schwann cells. In this study, we developed two lines of conditional RhoA knockout (cKO) mice to investigate the role of RhoA in Schwann cells during nerve injury and repair. Our results indicate that RhoA cKO in Schwann cells can accelerate axonal regrowth and remyelination after sciatic nerve injury, promoting the recovery of nerve conduction and hindlimb gait. Mechanistic studies revealed that RhoA cKO facilitates Schwann cell dedifferentiation via the JNK pathway, subsequently promoting Wallerian degeneration and stimulating the production of neurotrophins.
Article
Neurosciences
Jun Sun, Zhi Liao, Zhangyu Li, Hao Li, Zhimin Wu, Chuan Chen, Hui Wang
Summary: This study focused on investigating the roles and mechanisms of exosomes derived from Schwann cells under different conditions in regulating macrophagic sub-phenotypes and peripheral nerve injury repair. The study found that exosomes from normal oxygen condition Schwann cells promoted M2 macrophagic polarization and facilitated axon elongation, while exosomes from post-injury oxygen-glucose-deprivation-condition Schwann cells promoted M1 polarization and inhibited axon elongation. The down-regulation of miR-146a-5p was closely related to the shift of exosomes to pro-inflammatory phenotype. The study concluded that miR-146a-5p played an important role in regulating macrophagic phenotype and had implications for axonal regeneration and functional recovery.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Ophthalmology
Jie Zhang, Minfang Zhang, Wangbin Ouyang, Fang Wang, Shiying Li
Summary: The purpose of this study was to describe the characteristics of multispectral imaging (MSI) in patients with punctate inner choroidopathy (PIC) and choroidal neovascularisation (CNV) and compare them with current standard multimodal imaging techniques. The results showed that MSI can help noninvasively detect and observe the changes in choroidal vasculature, making it a promising tool for better tracking pathological changes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Cell Biology
Ruirui Zhang, Qi Chen, Li Huang, Yunsong Zhang, Xinghui Wang, Sheng Yi
Summary: The study analyzed single-cell transcriptional profiling of Schwann cells in neonatal rat sciatic nerves, revealing cellular heterogeneity and dynamic changes. It also identified differentiation trajectory from certain Schwann cell subtypes to others, with functional interpretation showing genetic signatures of DNA replication and acquisition of mesenchymal traits in subtype 3 Schwann cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Yinying Shen, Zhangchun Cheng, Sailing Chen, Yunsong Zhang, Qi Chen, Sheng Yi
Summary: miR-29a-3p is up-regulated in injured sciatic nerves and inhibits Schwann cell proliferation and migration by negatively regulating PMP22. Injection of miR-29a-3p agomir hinders Schwann cell activities, delays axon elongation and myelination, and retards the functional recovery of injured nerves. This highlights the important role of miR-29a-3p/PMP22 in regulating Schwann cell phenotype following sciatic nerve injury and peripheral nerve regeneration.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Yin-Ying Shen, Rui-Rui Zhang, Qian-Yan Liu, Shi-Ying Li, Sheng Yi
Summary: Cellular senescence and proliferation are essential for wound healing and tissue remodeling. This study analyzed gene expression patterns in rat sciatic nerve stumps and dorsal root ganglia after injury to reveal the genetic changes associated with cellular senescence and proliferation. The study found that cellular senescence and proliferation were less vigorous in the dorsal root ganglia compared to the sciatic nerve stumps.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Shaoyi Chen, Zuxiao Chen, Zongyan Li, Shiying Li, Zilong Wen, Liangqi Cao, Yubin Chen, Ping Xue, Haiyan Li, Dawei Zhang
Summary: This study investigated the effect of exosomal circular RNAs (CircRNAs) produced by tumor-associated macrophages on the microenvironment of cholangiocarcinoma cells, and identified Circ_0020256 as a promoter of proliferation, migration, and invasion in cholangiocarcinoma cells. This promotional activity was mediated by the interaction between Circ_0020256 and its intracellular microRNA target, miR-432-5p.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Siyu Chen, Minghui Li, Jianguo Sun, Dan Wang, Chuanhuang Weng, Yuxiao Zeng, Yijian Li, Shujia Huo, Xiaona Huang, Shiying Li, Ting Zou, Haiwei Xu
Summary: This study found that transplantation of human umbilical cord blood CD133(+)CD34(+) cells can protect retinal endothelial and ganglion cells of X-irradiated rat retinas through the secretion of angioprotective and neurotrophic factors, leading to the restoration of retinal function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Yunsong Zhang, Qian Zhao, Qianqian Chen, Lingchi Xu, Sheng Yi
Summary: Transcription factors play important roles in nerve regeneration after peripheral nerve injury, including regulating axon elongation and Schwann cell phenotype modulation. Understanding these transcription factors can help promote functional recovery of injured peripheral nerves.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Qian-Qian Chen, Qian-Yan Liu, Pan Wang, Tian-Mei Qian, Xing-Hui Wang, Sheng Yi, Shi-Ying Li
Summary: Neurotrophic factors, especially nerve growth factor, can enhance neuronal regeneration, but their in vivo applications are limited. This study investigated the potential of let-7 as a regulator in nerve repair, as it targets and regulates nerve growth factor. Anti-let-7a was identified as the most suitable let-7 family molecule, and its controlled delivery was achieved using a chitosan-hydrogel scaffold, promoting nerve regeneration and functional recovery in a rat model of sciatic nerve transection.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Chen, Yang Miao, Zhipeng Xu, Ruirui Zhang, Sheng Yi
Summary: Schwann cells play a crucial role in nerve regeneration and are commonly used in tissue engineering. Identifying Schwann cells with enhanced migration ability is important for improving recovery effects. This study compared Schwann cells from different anatomical locations and found that dorsal root ganglia (DRG) Schwann cells have faster migration speed than sciatic nerve (SN) Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Yunsong Zhang, Yinying Shen, Li Zhao, Qian Zhao, Lili Zhao, Sheng Yi
Summary: Nerve injury-induced Schwann cell dedifferentiation promotes axon growth by creating a favorable microenvironment. Transcription factor BCL11A plays a crucial role in Schwann cell reprogramming during peripheral nerve regeneration. Silencing Bcl11a reduces Schwann cell viability, proliferation, migration rates, and debris clearance ability. Bcl11a deficiency leads to restricted axon elongation and myelin wrapping, resulting in failed recovery. Mechanistically, BCL11A regulates Schwann cell activity by binding to the Nr2f2 promoter and modulating Nr2f2 expression. In conclusion, BCL11A is essential for Schwann cell activation and peripheral nerve regeneration, making it a potential therapeutic target for peripheral nerve injury treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Lili Zhao, Weixiao Huang, Sheng Yi
Summary: Single-cell RNA sequencing enables the classification and transcriptional profiling of individual cells, leading to a better understanding of cellular diversity. In the peripheral nervous system (PNS), this technique has identified multiple cell types including neurons, glial cells, ependymal cells, immune cells, and vascular cells. Subtypes of neurons and glial cells have also been recognized in different physiological and pathological states. This article summarizes the heterogeneity of cells in the PNS and describes cellular variability during development and regeneration, which provides insights into the complex cellular architecture of the PNS and serves as a basis for future genetic manipulation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Fanchu Zeng, Zhijin Fan, Shiying Li, Lanqing Li, Tong Sun, Yang Qiu, Liming Nie, Guojia Huang
Summary: This study presents an all-in-one theranostic nanoprobe for precise chemotherapy and real-time immune response tracing of glioblastoma. The nanoprobe effectively targets regulatory T lymphocytes and can be monitored using photoacoustic-fluorescence imaging. The combination of chemotherapy and immunotherapy shows promising results in enhancing immune response and reducing lymphocyte infiltration.
Article
Biochemistry & Molecular Biology
Sailing Chen, Qianqian Chen, Xiaojiao Zhang, Yinying Shen, Xinyu Shi, Xiu Dai, Sheng Yi
Summary: Peripheral nerves have limited ability to regenerate after injury. The growth factor amphiregulin (AREG) is upregulated in Schwann cells of injured sciatic nerves and stimulates their proliferation and migration. Schwann cell-secreted AREG promotes neurite outgrowth and axon elongation. Administering AREG to injured nerves facilitates Schwann cell proliferation, cord formation, and axon regrowth. Overall, our study identifies AREG as an important neurotrophic factor and offers a promising therapeutic approach for peripheral nerve injuries.
JOURNAL OF NEUROCHEMISTRY
(2023)
