Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

(2020) Alejandro Moreno-Domínguez et al.   Science Signaling

Cellular adaptation to oxygen deficiency beyond the Nobel award

(2020) José López-Barneo et al.   Nature Communications

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

(2020) Jaclyn A Smith et al.   Lancet Respiratory Medicine

Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

(2020) David Pajuelo Reguera et al.   Cells

Differentiating COVID-19 Pneumonia from Acute Respiratory Distress Syndrome (ARDS) and High Altitude Pulmonary Edema (HAPE): Therapeutic Implications

(2020) Stephen L. Archer et al.   CIRCULATION

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

(2020) Xiaotong Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia

(2020) Ying-Jie Peng et al.   JOURNAL OF NEUROPHYSIOLOGY

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Why COVID-19 Silent Hypoxemia Is Baffling to Physicians

(2020) Martin J. Tobin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress

(2019) Lifei Meng et al.   Thoracic Cancer

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Physiology of the Carotid Body: From Molecules to Disease

(2019) Patricia Ortega-Sáenz et al.   Annual Review of Physiology

Acute O 2 Sensing: Role of Coenzyme QH 2 /Q Ratio and Mitochondrial ROS Compartmentalization

(2018) Ignacio Arias-Mayenco et al.   Cell Metabolism

Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia

(2018) Verónica Sobrino et al.   EMBO REPORTS

Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression

(2018) Santhosh M. Baby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

High fat diet blunts the effects of leptin on ventilation and on carotid body activity

(2018) Maria J. Ribeiro et al.   JOURNAL OF PHYSIOLOGY-LONDON

PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies

(2018) James W. Fielding et al.   JOURNAL OF PHYSIOLOGY-LONDON

Variable role of carotid bodies in cardiovascular responses to exercise, hypoxia and hypercapnia in spontaneously hypertensive rats

(2018) Wioletta Pijacka et al.   JOURNAL OF PHYSIOLOGY-LONDON

HIF-2α is essential for carotid body development and function

(2018) David Macias et al.   eLife

The role of Olfr78 in the breathing circuit of mice

(2018) Hortensia Torres-Torrelo et al.   NATURE

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

(2018) Giuseppe Lucarelli et al.   Aging-US

Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells

(2017) Lin Gao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acute oxygen sensing by the carotid body: a rattlebag of molecular mechanisms

(2017) Ryan J. Rakoczy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adenosine and dopamine oppositely modulate a hyperpolarization-activated current I h in chemosensory neurons of the rat carotid body in co-culture

(2017) Min Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of cystathionine-γ-lyase in hypoxia-induced changes in TASK activity, intracellular [Ca 2+ ] and ventilation in mice

(2017) Jiaju Wang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body

(2017) Valentina Annese et al.   Cell Reports

Lifetime imaging of GFP at CoxVIIIa reports respiratory supercomplex assembly in live cells

(2017) Bettina Rieger et al.   Scientific Reports

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia

(2016) José López-Barneo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea

(2016) Amira D. Mahmoud et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structure of Mammalian Respiratory Supercomplex I 1 III 2 IV 1

(2016) Meng Wu et al.   CELL

Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study

(2016) Piotr Niewinski et al.   EUROPEAN JOURNAL OF HEART FAILURE

Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in RatsNovelty and Significance

(2016) Rodrigo Del Rio et al.   HYPERTENSION

Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion

(2016) Patricia Ortega-Sáenz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single cell transcriptome analysis of mouse carotid body glomus cells

(2016) Ting Zhou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Purinergic receptors in the carotid body as a new drug target for controlling hypertension

(2016) Wioletta Pijacka et al.   NATURE MEDICINE

Gene Expression Profiling Supports the Neural Crest Origin of Adult Rodent Carotid Body Stem Cells and Identifies CD10 as a Marker for Mesectoderm-Committed Progenitors

(2016) Elena Navarro-Guerrero et al.   STEM CELLS

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency

(2016) Johannes K. Ehinger et al.   Nature Communications

Nesfatin-1 promotes brown adipocyte phenotype

(2016) Yuexin Wang et al.   Scientific Reports

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers

(2015) M Roozekrans et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

(2015) Emma J. Hodson et al.   JOURNAL OF PHYSIOLOGY-LONDON

The subunit composition and function of mammalian cytochrome c oxidase

(2015) Bernhard Kadenbach et al.   MITOCHONDRION

Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics

(2015) Yeng F. Her et al.   International Journal of Endocrinology

An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia

(2014) Aida Platero-Luengo et al.   CELL

Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

(2014) D. Macias et al.   EMBO Molecular Medicine

Increase in cytosolic Ca2+produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body

(2014) Dawon Kang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors

(2014) Colin A. Nurse   JOURNAL OF PHYSIOLOGY-LONDON

A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21WAF1/Cip1 Induction and Mitochondrial Dysfunction

(2014) África Millán-Uclés et al.   PLoS One

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Role of the Carotid Body in the Pathophysiology of Heart Failure

(2013) Harold D. Schultz et al.   CURRENT HYPERTENSION REPORTS

Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets

(2013) Maria J. Ribeiro et al.   DIABETES

Post-translational Modifications near the Quinone Binding Site of Mammalian Complex I

(2013) Joe Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Carotid Body Denervation

(2013) Blair D. Johnson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Carotid Chemoreceptor Ablation Improves Survival in Heart Failure

(2013) Rodrigo Del Rio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

(2013) Siddhesh Aras et al.   NUCLEIC ACIDS RESEARCH

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension

(2013) Fiona D. McBryde et al.   Nature Communications

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

(2012) Maik Hüttemann et al.   FASEB JOURNAL

The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases

(2012) Julian F.R. Paton et al.   HYPERTENSION

P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP

(2012) Min Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Differential Impairment of Catecholaminergic Cell Maturation and Survival by Genetic Mitochondrial Complex II Dysfunction

(2012) B. Diaz-Castro et al.   MOLECULAR AND CELLULAR BIOLOGY

The carotid body in Sudden Infant Death Syndrome

(2012) Andrea Porzionato et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Hypoxia-inducible factor 2  (HIF-2 ) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension

(2011) Y.-J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: Role of the angiotensin II type 1 receptor

(2010) Noah J. Marcus et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Chronic Nicotine Blunts Hypoxic Sensitivity in Perinatal Rat Adrenal Chromaffin Cells via Upregulation of KATP Channels: Role of  7 Nicotinic Acetylcholine Receptor and Hypoxia-Inducible Factor-2 

(2009) J. Buttigieg et al.   JOURNAL OF NEUROSCIENCE

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Absolute requirement of GDNF for adult catecholaminergic neuron survival

(2008) Alberto Pascual et al.   NATURE NEUROSCIENCE

Sustained hypoxia-induced proliferation of carotid body type I cells in rats

(2007) Z.-Y. Wang et al.   JOURNAL OF APPLIED PHYSIOLOGY