Article
Pharmacology & Pharmacy
Yan Huang, Gang Wang, Zhan Zhou, Zhengshan Tang, Ningning Zhang, Xiaoyan Zhu, Xin Ni
Summary: The gasotransmitter H2S plays a crucial role in maintaining normal oxygen saturation in the lungs and preventing lung injury, inflammation, and oxidative stress. GYY4137 treatment was effective in ameliorating these conditions in both genetic deficiency and hypoxia-induced mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bindu D. Paul, Juan I. Sbodio, Solomon H. Snyder
Summary: This study found that cysteine metabolism is compromised at both transcriptional and post-translational levels in Huntington's disease, indicating that restoring cysteine homeostasis may be beneficial in treating this neurodegenerative disorder.
Article
Immunology
Andrea Porzionato, Aron Emmi, Martina Contran, Elena Stocco, Silvia Riccetti, Alessandro Sinigaglia, Veronica Macchi, Luisa Barzon, Raffaele De Caro
Summary: Analysis of carotid bodies from autopsies of COVID-19 cases revealed evidence of direct invasion of SARS-CoV-2 virus and local inflammatory reactions, along with vascular congestion and microthrombosis in some cases, suggesting potential effects on chemoreception even without direct invasion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qian Lin, Bin Geng
Summary: This article discusses the significant impact of atherosclerosis on cardiovascular events and global mortality, as well as the role of hydrogen sulfide in plaque stability and its regulation mechanism on different cell populations.
Review
Multidisciplinary Sciences
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Summary: H2S plays a crucial role in glucose metabolism by affecting insulin secretion, apoptosis of islet β cells, insulin sensitivity, glucose uptake, adipogenesis, lipolysis, and modulation of circadian-clock genes. Further studies are needed to determine whether H2S could be a promising target for diabetes mellitus treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang
Summary: The study highlights the important role of hydrogen sulfide in regulating ferroptosis and lipid peroxidation in mouse myoblasts and skeletal muscles. The downregulation of CSE/H2S signaling contributes to mitochondrial damage, abnormal lipid metabolism, membrane lipid peroxidation, and ferroptotic cell death, making CSE/H2S system a potential target for preventing ferroptosis in skeletal muscle.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Maria Romerowicz-Misielak, Katarzyna Koziol, Slawomir Nowak, Marek Koziorowski
Summary: Circadian clock genes play a crucial role in regulating rhythmic processes within cells and disruptions in their functioning are associated with various disorders. H2S has been identified as a key regulator of the circadian rhythm. Pharmacological inhibition of CBS and CSE affects the expression of the Per2 gene, with exposure to AOAA potentially influenced by factors other than CBS and CSE activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Agriculture, Dairy & Animal Science
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang
Summary: This study identified differentially expressed proteins (DEPs) associated with hydrogen sulfide metabolism in Holstein cows with clinical mastitis (CM), indicating the important role of cystathionine-gamma-lyase (CTH)/H2S in CM. The findings provide insight into the function and regulatory mechanism of CTH/H2S in Holstein cows and can contribute to the prevention and treatment of CM.
Article
Microbiology
Olga Martzoukou, Panayiotis D. Glekas, Margaritis Avgeris, Diomi Mamma, Andreas Scorilas, Dimitris Kekos, Sotiris Amillis, Dimitris G. Hatzinikolaou
Summary: In this study, researchers performed precise genome editing on the model biocatalyst Rhodococcus qingshengii IGTS8 for the first time, shedding light on the regulation of dsz gene expression and biocatalyst activity dependent on the presence of two reverse transsulfuration enzymes, C beta S and MetB. Additionally, they observed an enhancement of biodesulfurization capability in the presence of otherwise repressive sulfur sources like sulfate and L-methionine. The interconnection of cellular sulfur assimilation strategies was revealed and validated.
Article
Veterinary Sciences
Shaodong Fu, Zhenglei Wang, Xiangan Han, Yuanyuan Xu, Jinfeng Miao
Summary: We reported that E. coli infection enhances the expression of CSE in macrophages, leading to excessive inflammation. Excessive autophagy mediated this process. Our study highlights the importance of CSE in regulating the macrophage-mediated response to E. coli and provides a new drug target for treating intestinal infections.
VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai
Summary: This study found that transgenic mice overexpressing cystathionine gamma-lyase had higher plasma concentrations of cysteine persulfide (CysSSH). However, there were no significant differences in tissue concentrations of reactive sulfur species (RSS) between wild-type and transgenic mice. It was also observed that excess intracellular CysSSH could be exported from primary hepatocytes through a cystine-dependent transporter. The poor efflux of excess CysSSH resulted in increased cellular stresses, such as polysulfidation of proteins, mitochondrial damage, and cytotoxicity.
Article
Biochemistry & Molecular Biology
Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J. Lees, Rui Wang, Guangdong Yang
Summary: Hydrogen sulfide (H2S) plays a crucial role in maintaining myogenesis and may serve as a potential candidate for preventing age-related sarcopenia and treating muscle injury.
Article
Medicine, General & Internal
Nicole Denoix, Oscar McCook, Angelika Scheuerle, Thomas Kapapa, Andrea Hoffmann, Harald Guendel, Christiane Waller, Csaba Szabo, Peter Radermacher, Tamara Merz
Summary: This study investigated the effects of systemic H2S administration on the brain using neuro-histopathology and immunohistochemistry analysis. The results showed that Na2S2O3 could not penetrate the blood brain barrier in the hypothalamic PVN region, indicating no therapeutic effects in this area.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sunil Jamuna Tripathi, Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul
Summary: The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective effects in the brain through post-translational modification of cysteine residues by sulfhydration. It cannot be stored in vesicles due to its gaseous nature and is either synthesized or released from endogenous stores. Sulfhydration has both specific and general neuroprotective effects and is diminished in neurodegenerative disorders, while excessive cellular H2S is linked to certain forms of neurodegenerative disease. This review explores the role of H2S in signaling across various neurodegenerative diseases and age-related neurodegeneration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Mathan Kumar Marimuthu, Anbalagan Moorthy, Tamizhselvi Ramasamy
Summary: This study investigates the anti-inflammatory effect of diallyl disulfide (DADS) in acute pancreatitis and its molecular mechanisms. The results show that DADS can reduce the expression of inflammatory molecules and induce the expression of specific genes through the PPAR-γ pathway. This provides a new therapeutic strategy for the treatment of acute pancreatitis.
Article
Critical Care Medicine
Michael Groeger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Veronique Saub, Nicole Denoix, Oscar McCook, Enrico Calzia, Eva-Maria Wolfschmitt, Ulrich Wachter, Josef A. Vogt, Rui Wang, Peter Radermacher, Tamara Merz, Benedikt L. Nussbaum
Summary: This study investigated the effects of sodium thiosulfate (Na2S2O3) administration during resuscitation from trauma-and-hemorrhage in mice under conditions of whole body cystathionine gamma-lyase (CSE) deficit. The results showed that Na2S2O3 exerted beneficial effects in terms of organ protection and anti-inflammatory properties, improving lung function, reducing norepinephrine requirements, increasing urine output, and regulating inflammatory response and oxidative stress in the kidney tissue. These findings suggest that Na2S2O3 could be a potential therapeutic option in the context of impaired CSE activity and/or reduced endogenous H2S availability.
Article
Pharmacology & Pharmacy
Yan Yu, Jing-Jing Li, Xiao-Qian He, Zi-Ying Lai, Rui Hao, Yu Qi, Dong-Qing Cao, Ming Fu, Hong Ma, Qiu-Chen Xie, Mu Sun, Zhi-Li Huang, Ling-Jing Jin, Hui-hui Sun, Ning Lu, Rui Wang, Wing-Ho Yung, Ying Huang
Summary: This study found that dysfunction of the 5-HT3R affects synaptic plasticity between hippocampal neurons, leading to impairment in spatial memory. This effect is mediated through the CB1R-GABA(A) pathway on the 5-HT3R.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Huiying Huang, Siqing Zhu, Yuemei Han, Dong Liu, Sihao Liu, Duoduo Lu, Rui Wang, Quankui Lin
Summary: Posterior capsule opacification (PCO) is a common complication in cataract surgery, primarily caused by residual lens epithelial cells. Despite advancements in IOL surface modification techniques for PCO prevention, issues such as long-term efficacy and intraocular biocompatibility remain. This study presents a novel IOL modification approach with enzymes for efficient PCO suppression without toxic drugs, showcasing promising results in in vitro and in vivo evaluations.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Jiayi Xia, Yuemei Han, Liangliang Shen, Rui Wang, Shimin Wen, Siqing Zhu, Quankui Lin
Summary: A photo-responsive drug release coating was successfully constructed on IOL surface to inhibit PCO incidence. In vitro assay showed excellent anti-adhesion and anti-proliferation effects of the coating on LECs under irradiation, with photo-controlled drug release achieved by adjusting irradiation intensity and time.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Medicinal
Dongping Li, Kexin Jiang, Dan Teng, Zengrui Wu, Weihua Li, Yun Tang, Rui Wang, Guixia Liu
Summary: This study describes the discovery of novel potent agonists or inverse agonist of ERR alpha using a combined virtual screening approach. These compounds showed activity against ERR alpha in biological investigations and have different chemical structures from known agonists. The study also demonstrates the successful application of molecular dynamics-guided virtual screening in identifying ERR alpha agonists.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Medicine, General & Internal
Michael Groger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Enrico Calzia, Ulrich Wachter, Josef A. Vogt, Rui Wang, Tamara Merz, Peter Radermacher, Oscar McCook
Summary: This study investigated the therapeutic effects of sodium thiosulfate (STS) in mice with type 1 diabetes mellitus (DMT1). The results showed that STS did not have a therapeutic effect in DMT1 mice, possibly due to the more severe circulatory shock caused by DMT1.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zheling Feng, Jiali Chen, Cheng Chen, Lu Feng, Rui Wang, Jianzhong Zhu, Ruohan Lou, Jia Liu, Yang Ye, Ligen Lin
Summary: This study discovered that polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia cambogia have lipid-lowering effects and can induce browning of adipocytes. Among them, guttiferone J (GOJ) is the most potent inducer of browning, which activates the deacetylase SIRT3 to enhance mitochondrial biogenesis and thermogenesis. In high-fat diet-induced obese mice, GOJ protected against obesity and related disorders by promoting browning of adipose tissue.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ketan K. Thanki, Paul Johnson, Edward J. Higgins, Manjit Maskey, Ches'Nique Phillips, Swetaleena Dash, Francisco Arroyo Almenas, Armita Abdollahi Govar, Bing Tian, Romain Villeger, Ellen Beswick, Rui Wang, Csaba Szabo, Celia Chao, Irina Pinchuk, Mark R. Hellmich, Katalin Modis
Summary: Hydrogen sulfide (H2S) plays an important role in the development of ulcerative colitis (UC) and colitis-associated cancer (CAC). Inhibition of H2S production may worsen colitis and delay tissue healing. The expression of cystathionine-gamma-lyase (CSE) is critical in limiting mucosal inflammation and promoting epithelial cell proliferation, and CSE expression in bone marrow (BM) cells plays a key role in suppressing CAC.
Review
Biochemistry & Molecular Biology
Rui Wang, Chaoshu Tang
Summary: China has been conducting biomedical research on hydrogen sulfide (H2S) metabolism and function for the past 20 years, leading the way in investigating the correlation between abnormal H2S metabolism and cardiovascular diseases. Chinese research teams have made significant breakthrough discoveries in areas such as hypertension, atherosclerosis, and pulmonary hypertension, advancing both laboratory study and clinical applications. An integrated and collaborative research strategy can further promote and sustain H2S biomedical research in China and globally.
Review
Peripheral Vascular Disease
Rui Wang
Summary: Hypertension is a complex health challenge with multiple causes, while hydrogen sulfide (H2S) serves as a multifunctional gasotransmitter. Animal studies conducted 15 years ago have established the critical role of endogenous H2S deficiency in hypertension development, leading to further investigations into its cardiovascular effects and underlying molecular and cellular mechanisms. We are also beginning to understand the involvement of altered H2S metabolism in human hypertension. This article aims to provide a comprehensive understanding of H2S's roles in hypertension development in both animals and humans, and review H2S-based antihypertension therapeutic strategies.
Article
Biochemistry & Molecular Biology
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
Summary: Reactive sulfur species, such as cysteine hydropersulfide and glutathione persulfide, are produced abundantly in both prokaryotes and eukaryotes, including mammals. Cysteinyl-tRNA synthetase (CARS) has been identified as a new cysteine persulfide synthase (CPERS) responsible for the production of most reactive persulfides. However, the contribution of other enzymes, such as 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS), and cystathionine gamma-lyase (CSE), to reactive persulfide production is still debated. In this study, the authors used sulfur metabolome analysis to demonstrate that 3-MST, CBS, and CSE are not major sources of reactive persulfides in mammals, and CARS/CPERS is the principal enzyme involved.
Article
Chemistry, Medicinal
Rui Wang, Zhecheng Zhou, Xiaonan Wu, Xin Jiang, Linlin Zhuo, Mingzhe Liu, Hao Li, Xiangzheng Fu, Xiaojun Yao
Summary: This study proposes a feature-correction-based model for plant SSP recognition, called SE-SSP. The model uses Transformer encoders and a feature correction module to improve prediction performance, and applies contrastive learning strategy to mitigate the problem of sparse samples. Experimental results demonstrate the excellent performance of the proposed model.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Chemistry, Multidisciplinary
Tayebeh Amanpour, Rui Wang
Summary: Sulfenamides are organosulfur compounds that have a nitrogen-sulfur single bond structure. They play important roles in polymers used in various fields such as medicine, agrochemicals, veterinary medications, and environmental studies. This review focuses on the chemical reactions leading to sulfenamide production and their applications in cell biology and biochemistry.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Min Chen, Rui Wang, Qing-Xuan Ren, Bin Li, Ping Li, Hua Yang, Wen Gao
Summary: In this study, an online PB reaction coupled with SFC-MS was established to analyze C--C bonds in UFAs. The setup allowed for rapid capture of both prototype and product ions of FAs at the same retention time, significantly enhancing the accuracy of lipid identification. Additionally, a high C--C bond conversion rate was achieved, and the method demonstrated excellent relative quantification abilities.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Zhaoyu Ran, Yaru Zhang, Zhen Luo, Yujie Zhu, Mingti Wang, Rui Wang, Jing Fu, Qing Shao, Hui Quan, Hao Yuan, Jun Hu, Jinliang He, Qi Li
Summary: This study demonstrates the improved dielectric and capacitive performance of a polypropylene composite by grafting a molecular semiconductor onto polypropylene chains. The grafted molecular semiconductor introduces deep traps to inhibit the migration of high-energy charge carriers and enhances the regulation effect by positively influencing the microstructure of the polymer. The composite exhibits reduced leakage current, dielectric loss, electric field distortion, and increased breakdown strength at high temperatures.
MATERIALS TODAY ENERGY
(2023)
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)