Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals

Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms

(2020) Ke Lin et al.   Oxidative Medicine and Cellular Longevity

Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition

(2020) Janice Taïlé et al.   Antioxidants

Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules

(2020) Wei‐Yin Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway

(2019) Chao Niu et al.   Autophagy

Nutraceuticals as therapeutic agents for atherosclerosis

(2018) Joe W.E. Moss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

(2018) Rong Ke et al.   CELL BIOLOGY INTERNATIONAL

Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage

(2018) Rosalinda Madonna et al.   VASCULAR PHARMACOLOGY

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

(2018) Wei-Yin Wu et al.   Frontiers in Pharmacology

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

(2018) Ting Yuan et al.   Redox Biology

Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice

(2017) Rituparna Ganguly et al.   Scientific Reports

Acacetin from Traditionally Used Saussurea involucrata Kar. et Kir. Suppressed Adipogenesis in 3T3-L1 Adipocytes and Attenuated Lipid Accumulation in Obese Mice

(2017) Chian-Jiun Liou et al.   Frontiers in Pharmacology

The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells

(2017) Kui-Hao Chen et al.   Frontiers in Pharmacology

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

(2017) Liming Yu et al.   Scientific Reports

Clinical Update: Cardiovascular Disease in Diabetes Mellitus

(2016) Cecilia C. Low Wang et al.   CIRCULATION

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes

(2016) Manasi S. Shah et al.   CIRCULATION RESEARCH

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

(2016) Violeta I. Gallardo-Montejano et al.   Nature Communications

The changing face of diabetes complications

(2016) Edward W Gregg et al.   Lancet Diabetes & Endocrinology

Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs

(2016) Hui Liu et al.   Scientific Reports

Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury

(2016) Hui Liu et al.   Scientific Reports

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis

(2015) Arpeeta Sharma et al.   DIABETES

2013 Russell Ross Memorial Lecture in Vascular Biology

(2014) Karin E. Bornfeldt   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II

(2013) Joshua A. Beckman et al.   EUROPEAN HEART JOURNAL

Acacetin inhibits expression of E-selectin on endothelial cells through regulation of the MAP kinase signaling pathway and activation of NF-κB

(2013) Naomi Tanigawa et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Acacetin (5,7-dihydroxy-4′-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-κB/Akt signaling in prostate cancer cells

(2013) HYE RI KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53- and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner

(2012) David Cerna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

(2011) G. Rao et al.   DIABETOLOGIA

Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions

(2011) Anna-Maria Joseph et al.   Experimental Diabetes Research

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain

(2011) Hui-Jun Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Dietary Cholesterol Plays a Role in CD36-Mediated Atherogenesis in LDLR-Knockout Mice

(2009) David J. Kennedy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acacetin Inhibits TPA-Induced MMP-2 and u-PA Expressions of Human Lung Cancer Cells Through Inactivating JNK Signaling Pathway and Reducing Binding Activities of NF-κB and AP-1

(2009) Yaou Fong et al.   JOURNAL OF FOOD SCIENCE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs

(2008) Gui-Rong Li et al.   CIRCULATION

Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita

(2008) Ye Yin et al.   JOURNAL OF ETHNOPHARMACOLOGY