Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

(2018) Wei-Yin Wu et al.   Frontiers in Pharmacology

Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress

(2018) Lisha Zhao et al.   Redox Biology

Updates in Anthracycline-Mediated Cardiotoxicity

(2018) Canan G. Nebigil et al.   Frontiers in Pharmacology

Pharmacologic Inhibition of Autophagy Sensitizes Human Acute Leukemia Jurkat T Cells to Acacetin-Induced Apoptosis

(2017) Ji Young Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Flavonoids from Agrimonia pilosa Ledeb: Free Radical Scavenging and DNA Oxidative Damage Protection Activities and Analysis of Bioactivity-Structure Relationship Based on Molecular and Electronic Structures

(2017) Liancai Zhu et al.   MOLECULES

Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application

(2017) Fan Lan et al.   Nutrients

The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells

(2017) Kui-Hao Chen et al.   Frontiers in Pharmacology

Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells

(2017) Reenu Punia et al.   PLoS One

Cardiotoxicity of anthracycline therapy: current perspectives

(2016) Mihaela Valcovici et al.   Archives of Medical Science

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria

(2016) Ahmad Salimi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells

(2016) Yuan Wang et al.   Oncotarget

Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs

(2016) Hui Liu et al.   Scientific Reports

Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury

(2016) Hui Liu et al.   Scientific Reports

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

(2015) Yang Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sulforaphane protects the heart from doxorubicin-induced toxicity

(2015) Preeti Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis

(2015) Furqan Shaikh et al.   JNCI-Journal of the National Cancer Institute

Cardiotoxicity of anticancer treatments

(2015) Michael S. Ewer et al.   Nature Reviews Cardiology

Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis

(2015) Furqan Shaikh et al.   JNCI-Journal of the National Cancer Institute

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression

(2014) Qinghua Dong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure

(2014) X.S. Gu et al.   GENETICS AND MOLECULAR RESEARCH

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

(2012) Martin Štěrba et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain

(2011) Hui-Jun Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: A prospective, parallel-group, randomized, controlled study with 36-month follow-up

(2010) Peter Georgakopoulos et al.   AMERICAN JOURNAL OF HEMATOLOGY

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Acacetin Inhibits TPA-Induced MMP-2 and u-PA Expressions of Human Lung Cancer Cells Through Inactivating JNK Signaling Pathway and Reducing Binding Activities of NF-κB and AP-1

(2009) Yaou Fong et al.   JOURNAL OF FOOD SCIENCE

Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway

(2009) Kun-Hung Shen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs

(2008) Gui-Rong Li et al.   CIRCULATION

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY