Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
出版年份 2021 全文链接
标题
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-01-20
DOI
10.3389/fphar.2020.622153
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis
- (2020) Jing-Ting Chiou et al. CELL BIOLOGY AND TOXICOLOGY
- Amino acid-based compound activates atypical PKC and leptin receptor pathways to improve glycemia and anxiety like behavior in diabetic mice
- (2020) Aejin Lee et al. BIOMATERIALS
- A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement
- (2020) Mohammed Eslam et al. JOURNAL OF HEPATOLOGY
- DT-13 induced apoptosis and promoted differentiation of acute myeloid leukemia cells by activating AMPK-KLF2 pathway
- (2020) Chengqiang Wang et al. PHARMACOLOGICAL RESEARCH
- Empagliflozin protects heart from inflammation and energy depletion via AMPK activation
- (2020) Chintan N. Koyani et al. PHARMACOLOGICAL RESEARCH
- Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus
- (2019) Lee-Lee Lai et al. DIGESTIVE DISEASES AND SCIENCES
- Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
- (2019) Niki Katsiki et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet‐induced metabolic dysfunction and nonalcoholic fatty liver disease in mice
- (2019) Hao Chiang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Non‐alcoholic Fatty Liver Disease
- (2019) Fasiha Kanwal et al. HEPATOLOGY
- Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)
- (2018) Mohammad Shafi Kuchay et al. DIABETES CARE
- Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement
- (2018) Frédéric Brioude et al. Nature Reviews Endocrinology
- Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
- (2018) Hao Zhou et al. Redox Biology
- SGLT2 inhibitors and incretin agents: Associations with alanine aminotransferase activity in type 2 diabetes
- (2018) H.S. Bajaj et al. DIABETES & METABOLISM
- Evaluation of the effects of dapagliflozin, an SGLT2 inhibitor, on hepatic steatosis and fibrosis by transient elastography in patients with type 2 diabetes and non-alcoholic fatty liver disease
- (2018) Masanori Shimizu et al. DIABETES OBESITY & METABOLISM
- TET2 facilitates PPARγ agonist–mediated gene regulation and insulin sensitization in adipocytes
- (2018) Fuyun Bian et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
- (2018) Di Wu et al. NATURE
- Effect of sodium-glucose cotransporter 2 inhibitor, empagliflozin, and α-glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes
- (2018) Ji-Won Kim et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression
- (2017) Wen Pan et al. IMMUNITY
- Autophagy in the liver: functions in health and disease
- (2017) Takashi Ueno et al. Nature Reviews Gastroenterology & Hepatology
- ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
- (2017) Aishwarya Sathyanarayan et al. Cell Reports
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression
- (2016) Tae Seok Oh et al. Autophagy
- The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
- (2016) Simon A. Hawley et al. DIABETES
- Regulation of Liver Metabolism by Autophagy
- (2016) Julio Madrigal-Matute et al. GASTROENTEROLOGY
- Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus
- (2016) Yuya Seko et al. HEPATOLOGY RESEARCH
- Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells
- (2016) Ferdinand von Meyenn et al. MOLECULAR CELL
- NAFLD and diabetes mellitus
- (2016) Herbert Tilg et al. Nature Reviews Gastroenterology & Hepatology
- Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
- (2016) Teruo Jojima et al. Diabetology & Metabolic Syndrome
- Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE−/− mice
- (2016) Juan Peng et al. Oncotarget
- Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes
- (2015) Michael L. Multhaup et al. Cell Metabolism
- ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis
- (2015) Li Wang et al. HEPATOLOGY
- ER Stress and Autophagy Dysfunction Contribute to Fatty Liver in Diabetic Mice
- (2015) Quan Zhang et al. International Journal of Biological Sciences
- WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation
- (2015) Yiping Wang et al. MOLECULAR CELL
- TET1 is a tumor suppressor of hematopoietic malignancy
- (2015) Luisa Cimmino et al. NATURE IMMUNOLOGY
- Oxidized Low-Density Lipoprotein Inhibits THP-1-Derived Macrophage Autophagy via TET2 Down-regulation
- (2014) Guohua Li et al. LIPIDS
- Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
- (2014) Á González-Rodríguez et al. Cell Death & Disease
- Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models
- (2014) M Suzuki et al. Nutrition & Diabetes
- Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
- (2013) O. Abdel-Wahab et al. BLOOD
- Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
- (2013) Rohit A. Sinha et al. HEPATOLOGY
- Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease
- (2013) Yuka Fukuo et al. HEPATOLOGY RESEARCH
- AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail
- (2013) Mohamed Amine Zaouali et al. JOURNAL OF PINEAL RESEARCH
- Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
- (2013) William T Cefalu et al. LANCET
- Regulation of lipid stores and metabolism by lipophagy
- (2012) K Liu et al. CELL DEATH AND DIFFERENTIATION
- DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients
- (2012) Michael Volkmar et al. EMBO JOURNAL
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
- (2011) R. Grempler et al. DIABETES OBESITY & METABOLISM
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index
- (2010) A. P. Feinberg et al. Science Translational Medicine
- Glucose Control by the Kidney: An Emerging Target in Diabetes
- (2009) Olivera Marsenic AMERICAN JOURNAL OF KIDNEY DISEASES
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search