标题
Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease?
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 14, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-12-04
DOI
10.3389/fnins.2020.614643
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Alzheimer’s disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation
- (2020) Shehata Anwar et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Drug Repositioning for Alzheimer’s Disease: Finding Hidden Clues in Old Drugs
- (2020) Masafumi Ihara et al. JOURNAL OF ALZHEIMERS DISEASE
- Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
- (2020) David Gate et al. NATURE
- Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses
- (2020) Songlin Li et al. Frontiers in Immunology
- CD38 in Neurodegeneration and Neuroinflammation
- (2020) Serge Guerreiro et al. Cells
- Neuroinflammation in Alzheimer’s Disease: Friend or Foe?
- (2020) Caterina Scuderi et al. FASEB JOURNAL
- Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis
- (2020) Mengshi Zhou et al. PLoS One
- A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery
- (2020) Thanigaimalai Pillaiyar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation
- (2020) Artem P. Gureev et al. EXPERIMENTAL NEUROLOGY
- Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy
- (2020) Giulia Castellani et al. TRENDS IN IMMUNOLOGY
- 3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
- (2020) Chih-Tung Lin et al. eLife
- The immune system on the TRAIL of Alzheimer’s disease
- (2020) Chiara Burgaletto et al. Journal of Neuroinflammation
- PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model
- (2019) Neta Rosenzweig et al. Nature Communications
- Rapamycin and Alzheimer’s disease: Time for a clinical trial?
- (2019) Matt Kaeberlein et al. Science Translational Medicine
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Systemic and CNS inflammation crosstalk: implications for Alzheimer’s Disease
- (2019) Evi Paouri et al. Current Alzheimer Research
- Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzheimer's disease
- (2019) JIAE Park et al. CYTOTHERAPY
- Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse
- (2019) Xia Wang et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination
- (2019) Jureepon Roboon et al. Frontiers in Cellular Neuroscience
- Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model
- (2019) Giulia Di Benedetto et al. Journal of Neuroinflammation
- Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression
- (2019) Nicolas Curdy et al. TRENDS IN CELL BIOLOGY
- Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases
- (2019) Nicole K. Rogers et al. JOURNAL OF ALZHEIMERS DISEASE
- Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
- (2019) Yoo Jin Jung et al. Frontiers in Cell and Developmental Biology
- Alzheimer’s Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?
- (2018) Melissa A. O’Neal et al. ACS Chemical Neuroscience
- Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment
- (2018) Candice E. Van Skike et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease
- (2018) Sophie Steeland et al. EMBO Molecular Medicine
- Immunomodulatory effects of CD38-targeting antibodies
- (2018) Niels W.C.J. van de Donk IMMUNOLOGY LETTERS
- Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice
- (2018) Tomomi Kiyota et al. JOURNAL OF NEUROIMMUNOLOGY
- Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer’s Disease: Mechanisms, Drug Candidates, and New Opportunities
- (2018) Wing-Yu Fu et al. ACS Chemical Neuroscience
- PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration
- (2018) J. Obst et al. BRAIN BEHAVIOR AND IMMUNITY
- Postmortem T2*- Weighted MRI Imaging of Cortical Iron Reflects Severity of Alzheimer’s Disease
- (2018) Marjolein Bulk et al. JOURNAL OF ALZHEIMERS DISEASE
- Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models
- (2017) Martine Latta-Mahieu et al. GLIA
- Cholinergic modulation of the hippocampal region and memory function
- (2017) Juhee Haam et al. JOURNAL OF NEUROCHEMISTRY
- Peripheral Tumor Necrosis Factor-Alpha (TNF-α) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice
- (2017) Evi Paouri et al. JOURNAL OF NEUROSCIENCE
- Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease
- (2017) Melissa K. Edler et al. NEUROBIOLOGY OF AGING
- Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice
- (2017) Kathryn P. MacPherson et al. NEUROBIOLOGY OF DISEASE
- Calcineurin inhibitors improve memory loss and neuropathological changes in mouse model of dementia
- (2017) Amit Kumar et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Adalimumab in the Treatment of Immune-Mediated Diseases
- (2017) G. Lapadula et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Infliximab ameliorates AD-associated object recognition memory impairment
- (2016) Dong Hyun Kim et al. BEHAVIOURAL BRAIN RESEARCH
- Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer’s Disease
- (2016) Fiammetta Monacelli et al. JOURNAL OF ALZHEIMERS DISEASE
- Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
- (2016) Anthony J. Filiano et al. NATURE
- PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease
- (2016) Kuti Baruch et al. NATURE MEDICINE
- Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model
- (2016) Chelsea Cavanagh et al. NEUROBIOLOGY OF AGING
- Drug development in Alzheimer’s disease: the path to 2025
- (2016) Jeffrey Cummings et al. Alzheimers Research & Therapy
- Effects of systemic Thalidomide and intracerebroventricular Etanercept and Infliximab administration in a Streptozotocin induced dementia model in rats
- (2015) H. Kübra Elçioğlu et al. ACTA HISTOCHEMICA
- Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model
- (2015) Eran Blacher et al. ANNALS OF NEUROLOGY
- Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease
- (2015) Yosef Koronyo et al. BRAIN
- How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story
- (2015) Arlan Richardson et al. EXPERIMENTAL GERONTOLOGY
- Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition
- (2015) Lalida Rojanathammanee et al. Journal of Neuroinflammation
- Innate immunity in Alzheimer's disease
- (2015) Michael T Heneka et al. NATURE IMMUNOLOGY
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial
- (2015) J. Butchart et al. NEUROLOGY
- On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation
- (2015) Alexander M. Lesokhin et al. Science Translational Medicine
- Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
- (2015) Kuti Baruch et al. Nature Communications
- T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment
- (2015) Li Chen et al. Scientific Reports
- Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons
- (2014) A.E. Ramírez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease
- (2014) Giuseppina Cantarella et al. BRAIN
- Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation
- (2014) Michal Schwartz et al. JOURNAL OF AUTOIMMUNITY
- CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles
- (2014) C. Raposo et al. JOURNAL OF NEUROSCIENCE
- Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
- (2014) Gabriel Olmos et al. MEDIATORS OF INFLAMMATION
- Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice
- (2014) E.R. Detrait et al. NEUROCHEMISTRY INTERNATIONAL
- Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease
- (2014) Teng Jiang et al. PHARMACOLOGICAL RESEARCH
- Parallel Discovery of Alzheimer's Therapeutics
- (2014) A. W. Lo et al. Science Translational Medicine
- Minocycline: far beyond an antibiotic
- (2013) N Garrido-Mesa et al. BRITISH JOURNAL OF PHARMACOLOGY
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Glatiramer Acetate: A Review of Its Use in Patients with Relapsing-Remitting Multiple Sclerosis and in Delaying the Onset of Clinically Definite Multiple Sclerosis
- (2013) Lesley J. Scott CNS DRUGS
- Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease
- (2013) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase
- (2013) Yudong Liu et al. NEUROCHEMISTRY INTERNATIONAL
- Neuroinflammatory Cytokine Signaling and Alzheimer's Disease
- (2013) W. Sue T. Griffin NEW ENGLAND JOURNAL OF MEDICINE
- Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease
- (2013) Ping He et al. PLoS One
- Immunomodulatory drugs: Oral and systemic adverse effects
- (2013) A. Bascones-Martinez et al. Medicina Oral Patologia Oral y Cirugia Bucal
- Role of the PD-1 Pathway in the Immune Response
- (2012) L. V. Riella et al. AMERICAN JOURNAL OF TRANSPLANTATION
- 3,6′-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit
- (2012) Isabella Russo et al. JOURNAL OF NEUROCHEMISTRY
- Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease
- (2012) S Prasad Gabbita et al. Journal of Neuroinflammation
- Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
- (2012) Maria Teresa Ferretti et al. Journal of Neuroinflammation
- TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
- (2012) Karim Belarbi et al. Journal of Neuroinflammation
- Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
- (2012) David Tweedie et al. Journal of Neuroinflammation
- Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?
- (2012) Zhiyou Cai et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease
- (2012) Barbara Biscaro et al. Neurodegenerative Diseases
- Inhibition of Soluble Tumor Necrosis Factor Ameliorates Synaptic Alterations and Ca2+ Dysregulation in Aged Rats
- (2012) Diana M. Sama et al. PLoS One
- Glatiramer Acetate in the Treatment of Multiple Sclerosis
- (2011) Patrice H. Lalive et al. CNS DRUGS
- Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
- (2011) Renato X. Santos et al. JOURNAL OF NEUROCHEMISTRY
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains
- (2010) Jian-Quan Shi et al. BRAIN RESEARCH
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inflammasome signaling at the heart of central nervous system pathology
- (2010) Swarupa Chakraborty et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Alzheimer's disease: strategies for disease modification
- (2010) Martin Citron NATURE REVIEWS DRUG DISCOVERY
- Microglia in neurodegenerative disease
- (2010) V. Hugh Perry et al. Nature Reviews Neurology
- Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice
- (2010) Anete Rozkalne et al. NEUROBIOLOGY OF DISEASE
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- TopHat: discovering splice junctions with RNA-Seq
- (2009) Cole Trapnell et al. BIOINFORMATICS
- Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism
- (2009) Fabienne Giuliani et al. BRAIN RESEARCH BULLETIN
- CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV-1 brain infection
- (2009) Wei Kou et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
- (2009) H Quach et al. LEUKEMIA
- Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
- (2009) Fiona E. McAlpine et al. NEUROBIOLOGY OF DISEASE
- Risk Factors for Alzheimer Dementia in a Community-Based Birth Cohort at the Age of 75 Years
- (2008) Peter Fischer et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
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