Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

Inhibition of Autophagy Causes Tau Proteolysis by Activating Calpain in Rat Brain

(2017) Jia-yu Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: A General Introduction and Pathomechanism

(2017) Verena H. Finder   JOURNAL OF ALZHEIMERS DISEASE

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

(2016) J. Julie Wu et al.   Aging-US

Delivery of cytoplasmic proteins to autophagosomes

(2014) Kazufumi Ohshiro et al.   Autophagy

Adaptive autophagy in Alexander disease-affected astrocytes

(2014) Guomei Tang et al.   Autophagy

Amelioration of protein misfolding disease by rapamycin: Translation or autophagy?

(2014) Andreas Wyttenbach et al.   Autophagy

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

Apomorphine and Alzheimer Aβ: Roles for regulated α cleavage, autophagy, and antioxidation?

(2011) John W. Steele et al.   ANNALS OF NEUROLOGY

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

Chasing the elusive mammalian microautophagy

(2011) Laura Santambrogio et al.   Autophagy

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Systems biology of the autophagy-lysosomal pathway

(2011) Anil G. Jegga et al.   Autophagy

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells

(2011) Mariko Taga et al.   FEBS LETTERS

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease

(2011) Renato X. Santos et al.   JOURNAL OF NEUROCHEMISTRY

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes A  Generation

(2011) I. Y. Tamboli et al.   JOURNAL OF NEUROSCIENCE

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

(2011) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Lysosome positioning coordinates mTORC1 activity and autophagy

(2011) Christian Poüs et al.   NATURE CELL BIOLOGY

Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases

(2011) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells

(2011) Fangfang Zhou et al.   Protein & Cell

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

(2010) Daijun Ling et al.   ACTA NEUROPATHOLOGICA

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

(2010) Maryam Mehrpour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Beclin 1 Complex in Autophagy and Alzheimer Disease

(2010) Philipp A. Jaeger et al.   ARCHIVES OF NEUROLOGY

Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells

(2010) Eliza Vakana et al.   Autophagy

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

(2010) Yipeng Wang et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Rapamycin promotes β-amyloid production via ADAM-10 inhibition

(2010) Sheqing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers

(2010) Iain C. Anthony et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

(2010) Itay Koren et al.   CURRENT BIOLOGY

MAP4K3 regulates body size and metabolism in Drosophila

(2010) Boris Bryk et al.   DEVELOPMENTAL BIOLOGY

Targeting Tau Protein in Alzheimerʼs Disease

(2010) Cheng-Xin Gong et al.   DRUGS & AGING

Potential Predictors of Hippocampal Atrophy in Alzheimerʼs Disease

(2010) Vikas Dhikav et al.   DRUGS & AGING

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation

(2010) Valérie Vingtdeux et al.   FASEB JOURNAL

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

(2010) Philip J. Dolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

(2010) Barry Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator

(2010) H.-J. Wen et al.   JOURNAL OF VIROLOGY

Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer's Disease

(2010) Sarah F. Funderburk et al.   MOUNT SINAI JOURNAL OF MEDICINE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease

(2010) J.-F. Ma et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of rapamycin in adrenal chromaffin cells: Effect on tau phosphorylation

(2010) Takayuki Nemoto et al.   NEUROPHARMACOLOGY

Activation of mammalian target of rapamycin signaling in spatial learning

(2010) Sihua Qi et al.   NEUROSCIENCE RESEARCH

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

(2010) Akiko Kuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A central role for autophagy in Alzheimer type neurodegeneration

(2009) Daijun Ling et al.   Autophagy

mTOR regulates autophagy-associated genes downstream of p73

(2009) Jennifer M. Rosenbluth et al.   Autophagy

Translational responses to growth factors and stress

(2009) Megan Cully et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells

(2009) Chia-Li Kao et al.   CANCER LETTERS

Vesicular trafficking and autophagosome formation

(2009) A Longatti et al.   CELL DEATH AND DIFFERENTIATION

Turnover of organelles by autophagy in yeast

(2009) Jean-Claude Farré et al.   CURRENT OPINION IN CELL BIOLOGY

The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice

(2009) Juan Perucho et al.   EXPERIMENTAL NEUROLOGY

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

(2009) Tsuyoshi Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability

(2009) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKR, a cognitive decline biomarker, can regulate translationviatwo consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

(2009) Milena Damjanac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

(2009) Milena Morel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2

(2009) Milena Morel et al.   NEUROBIOLOGY OF DISEASE

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

(2009) Yifeng Du et al.   NEUROBIOLOGY OF DISEASE

BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

(2009) Neville Marks et al.   NEUROCHEMICAL RESEARCH

Variations in the effects on synthesis of amyloidβprotein in modulated autophagic conditions

(2009) Kouki Makioka et al.   NEUROLOGICAL RESEARCH

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

(2009) J. Vogel et al.   NEUROPHARMACOLOGY

Immune Regulation by Rapamycin: Moving Beyond T Cells

(2009) M. R. Janes et al.   Science Signaling

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

(2008) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy: Principles and significance in health and disease

(2008) Virginia Todde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tau as a biomarker of neurodegenerative diseases

(2008) Susanna Schraen-Maschke et al.   Biomarkers in Medicine

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E

(2008) Atsuo Mizuno et al.   FEBS LETTERS

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

(2008) Jose A. Rodríguez-Navarro et al.   HUMAN MOLECULAR GENETICS

Glycogen Synthase Kinase (GSK) 3β Directly Phosphorylates Serine 212 in the Regulatory Loop and Inhibits Microtubule Affinity-regulating Kinase (MARK) 2

(2008) Thomas Timm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease

(2008) Seung Yong Yoon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ordered Organelle Degradation during Starvation-induced Autophagy

(2008) Anders Riis Kristensen et al.   MOLECULAR & CELLULAR PROTEOMICS

The mTOR pathway and its role in human genetic diseases

(2008) M ROSNER et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE

Survival in Alzheimer disease: A multiethnic, population-based study of incident cases

(2008) E. P. Helzner et al.   NEUROLOGY

mTOR—What Does It Do?

(2008) M.N. Hall   TRANSPLANTATION PROCEEDINGS

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer’s disease

(2007) Milena Damjanac et al.   NEUROBIOLOGY OF DISEASE