Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Rab27a plays a dual role in metastatic propensity of pancreatic cancer

(2020) Nancy Kren et al.   Scientific Reports

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

(2019) Vincent Hyenne et al.   DEVELOPMENTAL CELL

Metastasis Organotropism: Redefining the Congenial Soil

(2019) Yang Gao et al.   DEVELOPMENTAL CELL

Metastatic-niche labelling reveals parenchymal cells with stem features

(2019) Luigi Ombrato et al.   NATURE

The ProteomeXchange consortium in 2020: enabling ‘big data’ approaches in proteomics

(2019) Eric W Deutsch et al.   NUCLEIC ACIDS RESEARCH

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

(2018) James Monypenny et al.   Cell Reports

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

(2018) Giulia Zago et al.   eLife

RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer

(2017) Chao Yan et al.   PHARMACOLOGICAL REVIEWS

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

(2017) Michael P. Plebanek et al.   Nature Communications

Going live with tumor exosomes and microvesicles

(2017) Vincent Hyenne et al.   Cell Adhesion & Migration

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

(2016) Soshi Kanemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics

(2016) Samuel Wieczorek et al.   BIOINFORMATICS

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

(2015) L Treps et al.   ONCOGENE

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

KRAS-dependent sorting of miRNA to exosomes

(2015) Diana J Cha et al.   eLife

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding

(2015) Shijing Yue et al.   Oncotarget

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

(2015) Thorsten Jung et al.   NEOPLASIA

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame

(2014) Leanna R. Gentry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival

(2014) Qingqing Wang et al.   MEDICAL ONCOLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis

(2014) Claudia Mattissek et al.   MOLECULAR MEMBRANE BIOLOGY

Discovery and characterization of small molecules that target the GTPase Ral

(2014) Chao Yan et al.   NATURE

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Elevated Concentration of Microvesicles Isolated from Peripheral Blood in Breast Cancer Patients

(2013) Octavio Galindo-Hernandez et al.   ARCHIVES OF MEDICAL RESEARCH

A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease

(2012) Punit Kaur et al.   BMC CANCER

CD146, a multi-functional molecule beyond adhesion

(2012) Zhaoqing Wang et al.   CANCER LETTERS

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells

(2011) Guo-fang Zeng et al.   BMC CANCER

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer

(2011) Q. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

(2011) Paul Timpson et al.   Jove-Journal of Visualized Experiments

CD146 Short Isoform Increases the Proangiogenic Potential of Endothelial Progenitor Cells In Vitro and In Vivo

(2010) Abdeldjalil Kebir et al.   CIRCULATION RESEARCH

CD146 and its Soluble Form Regulate Monocyte Transendothelial Migration

(2009) Nathalie Bardin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

(2009) Jana A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Circulating tumour-derived microvesicles in plasma of gastric cancer patients

(2009) Jaroslaw Baran et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

(2008) Yuanmei Lou et al.   DEVELOPMENTAL DYNAMICS