Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function

(2020) Yachen Shen et al.   Cell Reports

Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy

(2020) Ning Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy

(2020) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

(2020) Weiwei Mu et al.   Nano-Micro Letters

Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

(2020) Yalei Miao et al.   Nano-Micro Letters

Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy

(2020) Yang Li et al.   Nano-Micro Letters

Biochemical reprogramming of tumors for active modulation of receptor-mediated nanomaterial delivery

(2020) Seungbeom Ko et al.   BIOMATERIALS

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

(2019) Dongyoon Kim et al.   Acta Pharmaceutica Sinica B

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy

(2019) Michinari Nakamura et al.   Cell Metabolism

Properties of Poly-γ-Glutamic Acid Producing-Bacillus Species Isolated From Ogi Liquor and Lemon-Ogi Liquor

(2019) Titilayo A. Ajayeoba et al.   Frontiers in Microbiology

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence

(2019) Quoc-Viet Le et al.   ACS Nano

SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism

(2019) Tianshi Wang et al.   MOLECULAR CELL

Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism

(2019) Alexandra Collin de l’Hortet et al.   Cell Metabolism

Structural basis of assembly of the human T cell receptor–CD3 complex

(2019) De Dong et al.   NATURE

The Good and the Bad of Mitochondrial Breakups

(2019) Hans-Georg Sprenger et al.   TRENDS IN CELL BIOLOGY

Tumor Neoantigens: When Too Much of a Good Thing Is Bad

(2019) Anne Trinh et al.   CANCER CELL

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

(2019) Haoxin Li et al.   Nature Communications

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Advances in targeting the folate receptor in the treatment/imaging of cancers

(2018) Marcos Fernández et al.   Chemical Science

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy

(2018) Partha S. Chowdhury et al.   Cancer Immunology Research

Fenofibrate improves vascular endothelial function and contractility in diabetic mice

(2018) Nan Xu et al.   Redox Biology

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

(2017) Srinivasa Reddy Bonam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

(2017) Zhiyuan Niu et al.   Nature Communications

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

(2015) Hsiang-Ying Lee et al.   NATURE

γ-PGA-Coated Mesoporous Silica Nanoparticles with Covalently Attached Prodrugs for Enhanced Cellular Uptake and Intracellular GSH-Responsive Release

(2015) Xin Du et al.   Advanced Healthcare Materials

Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime–protein boost HIV-1 vaccine

(2014) Kimberly Pouliot et al.   VACCINE

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy

(2012) W. N. Brennen et al.   MOLECULAR CANCER THERAPEUTICS