MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

(2020) Rajashree A. Deshpande et al.   Science Advances

NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation

(2019) Roopesh Anand et al.   EMBO JOURNAL

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

(2019) Julio Aguado et al.   Nature Communications

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

(2018) Flavia Michelini et al.   CHEMICAL REVIEWS

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

(2018) Denisse Carvajal-Maldonado et al.   NUCLEIC ACIDS RESEARCH

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

(2018) Wei-Ting Lu et al.   Nature Communications

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

20 Years of Mre11 Biology: No End in Sight

(2018) Tanya T. Paull   MOLECULAR CELL

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment

(2018) Giuseppina D’Alessandro et al.   Nature Communications

Express or repress? The transcriptional dilemma of damaged chromatin

(2017) Ilaria Capozzo et al.   FEBS Journal

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

(2017) Weibin Wang et al.   GENES & DEVELOPMENT

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

(2017) Giordano Reginato et al.   GENES & DEVELOPMENT

Transcription and DNA Damage: Holding Hands or Crossing Swords?

(2017) Giuseppina D'Alessandro et al.   JOURNAL OF MOLECULAR BIOLOGY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

(2017) Francesca Rossiello et al.   Nature Communications

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling

(2017) Sarah Marie Henrich et al.   Scientific Reports

Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair

(2016) Qinhong Wang et al.   CANCER RESEARCH

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors

(2016) Sofia Francia et al.   JOURNAL OF CELL SCIENCE

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

(2016) Roopesh Anand et al.   MOLECULAR CELL

Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

(2016) Yiping Qi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair

(2016) Shuren Liao et al.   NUCLEIC ACIDS RESEARCH

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

(2016) Pauline Chanut et al.   Nature Communications

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex

(2015) Yaqi Liu et al.   EMBO JOURNAL

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

(2015) Petr Cejka   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

(2015) Andrea J Hartlerode et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

(2015) Andrea J Hartlerode et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

(2014) Min Gao et al.   CELL RESEARCH

The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes

(2014) Tanya T. Paull et al.   EXPERIMENTAL CELL RESEARCH

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks

(2014) Elda Cannavo et al.   NATURE

The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

(2014) Dorthe H. Larsen et al.   NATURE CELL BIOLOGY

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET

(2013) B. Cannon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A direct role for small non-coding RNAs in DNA damage response

(2013) Fabrizio d’Adda di Fagagna   TRENDS IN CELL BIOLOGY

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

(2011) Zhenbao Yu et al.   CELL RESEARCH

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Sub1 and RPA Associate with RNA Polymerase II at Different Stages of Transcription

(2011) Timothy W. Sikorski et al.   MOLECULAR CELL

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair

(2009) Céline Roques et al.   EMBO JOURNAL

Direct Inhibition of RNA Polymerase II Transcription by RECQL5

(2009) Ozan Aygün et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

A Glycine-Arginine Domain in Control of the Human MRE11 DNA Repair Protein

(2008) U. Dery et al.   MOLECULAR AND CELLULAR BIOLOGY

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology