Review
Gastroenterology & Hepatology
J. Scott Lee, Ruth X. Wang, Erica E. Alexeev, Sean P. Colgan
Summary: Inflammatory bowel disease is associated with significant changes in microbiota and host metabolic energy supply and demand. Components of the microbiota play important roles in various biochemical pathways within and outside of the mucosa, and adjusting energy acquisition in the gut may be beneficial for disease treatment.
Review
Oncology
Furong Qing, Tao Xie, Lu Xie, Tianfu Guo, Zhiping Liu
Summary: Dysregulation of gut microbiota is considered an important contributing factor to intestinal inflammatory disorders, and modifying innate immune receptors and relevant molecules could be a therapeutic approach for the treatment of these diseases.
Article
Immunology
Hongyan Lin, Xiaopeng Ma, Xiaorong Yang, Qingqing Chen, Zhongling Wen, Minkai Yang, Jiangyan Fu, Tongming Yin, Guihua Lu, Jinliang Qi, Hongwei Han, Yonghua Yang
Summary: This study identified SK and acetyl-SK, especially SK, as potential preventive agents for CAC through regulating both gut microbes and pathways involved in inflammation and cancer such as Wnt/β-catenin signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Lanzhou Li, Honghan Liu, Jinqi Yu, Zhen Sun, Ming Jiang, Han Yu, Chunyue Wang
Summary: Auricularia delicate can inhibit colitis-associated colorectal cancer (CAC) through regulating intestinal microbiota and affecting the NF-kappa B pathway and inflammation.
Review
Gastroenterology & Hepatology
Yue Yin, Jian Wan, Jingmin Yu, Kaichun Wu
Summary: This review summarizes the molecular pathogenesis of colitis-associated colorectal cancer (CAC) from the aspects of immunity, genetics, and intestinal microecology, and it points out the potential mechanisms worthy of further study. It highlights the complexity of the inflammation process to cancer and the dual effects of inflammatory mediators in order to provide inspiration for finding effective biomarkers or targets to make CAC more predictable and treatable.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Wenwen Zhu, Jia Li, Yujie Chen, Zhuo Liu, Qingyu Zhang, Chunsheng Kang
Summary: AC1Q3QWB (AQB) exhibits potent antitumor activity against colorectal cancer in vivo, possibly by modulating the immune system and altering the intestinal microbiota.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Yan Geng, Yuanjia Yue, Qijie Guan, Yilin Ren, Lin Guo, Yifei Fan, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu
Summary: The study demonstrated that CVS alleviates spontaneous ulcerative colitis in Il-10(-/-) mice by regulating inflammation and gut microbiota composition. CVS supplementation may serve as a protective dietary nutrient against colitis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Microbiology
Kai Xia, Renyuan Gao, Lin Li, Xiaocai Wu, Tianqi Wu, Yu Ruan, Lu Yin, Chunqiu Chen
Summary: Intestinal inflammation caused by gut microbiota plays a crucial role in promoting colorectal cancer, particularly in colitis-associated CRC. This review focuses on exploring the potential correlations between gut microbiota and colitis-associated CRC, as well as discussing promising microbiota-based strategies such as probiotics, prebiotics, microbiota-derived metabolites, and fecal microbiota transplantation.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Oncology
Alice Bertocchi, Sara Carloni, Paola Simona Ravenda, Giovanni Bertalot, Ilaria Spadoni, Antonino Lo Cascio, Sara Gandini, Michela Lizier, Daniele Braga, Francesco Asnicar, Nicola Segata, Chris Klaver, Paola Brescia, Elio Rossi, Achille Anselmo, Silvia Guglietta, Annalisa Maroli, Paola Spaggiari, Noelia Tarazona, Andres Cervantes, Silvia Marsoni, Luca Lazzari, Maria Giovanna Jodice, Chiara Luise, Marco Erreni, Salvatore Pece, Pier Paolo Di Fiore, Giuseppe Viale, Antonino Spinelli, Chiara Pozzi, Giuseppe Penna, Maria Rescigno
Summary: Bacteria from primary tumors can lead to bacterial dissemination from the intestine to the liver, disrupting the gut vascular barrier, boosting the formation of a premetastatic niche, and enhancing the recruitment of metastatic cells. High levels of PV-1, a marker of impaired gut vascular barrier, are associated with liver bacteria dissemination and metachronous distant metastases in colorectal cancer patients, making it a prognostic marker for distant recurrence and vascular impairment.
Article
Multidisciplinary Sciences
Xiaoyang Ma, Yoon-Jung Shin, Hyo-Min Jang, Min-Kyung Joo, Jong-Wook Yoo, Dong-Hyun Kim
Summary: The study showed that human fecal Lactobacillus rhamnosus NK210 and Bifidobacterium longum NK219 have positive effects on immune homeostasis, particularly in controlling immune imbalance and gut dysbiosis.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Yingjie Dong, Qiuli Yang, Ruiying Niu, Zhiyuan Zhang, Yijin Huang, Yujing Bi, Guangwei Liu
Summary: Intestinal macrophages play a crucial role in maintaining intestinal homeostasis, inflammation, and cancer development. Understanding their functions and regulatory mechanisms is of great importance for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Reiner Schneider, Patrick Leven, Shilpashree Mallesh, Mona Bresser, Linda Schneider, Elvio Mazzotta, Paola Fadda, Tim Glowka, Tim O. Vilz, Philipp Lingohr, Joerg C. Kalff, Fievos L. Christofi, Sven Wehner
Summary: IL1R1 signaling triggers enteric gliosis, resulting in macrophage activation and the development of postoperative ileus.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Nutrition & Dietetics
Daotong Li, Yu Feng, Meiling Tian, Xiaosong Hu, Ruimao Zheng, Fang Chen
Summary: The study found that barley leaf supplementation can prevent colorectal cancer by reducing weight loss, inhibiting tumor formation, improving tissue damage, reducing cell proliferation and gene expression levels, and promoting the enrichment of Bifidobacterium.
Review
Immunology
Sisi Mo, Haiming Ru, Maosen Huang, Linyao Cheng, Xianwei Mo, Linhai Yan
Summary: Microbial disorders are associated with the pathogenesis of various malignant tumors. The oral and intestinal tract are important microbial habitats in the human body, but they have limited communication. However, evidence suggests that oral microbiota can colonize the gut, leading to dysregulation of gut microbes and promoting the development of colorectal cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2022)