In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

The promise of mRNA vaccines: a biotech and industrial perspective

(2020) Nicholas A. C. Jackson et al.   npj Vaccines

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities

(2020) Johan Karlsson et al.   Expert Opinion on Drug Delivery

Allogeneic CAR T cell therapies for leukemia - R1

(2019) Waseem Qasim   AMERICAN JOURNAL OF HEMATOLOGY

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

(2019) Jessica B. Foster et al.   MOLECULAR THERAPY

How mRNA therapeutics are entering the monoclonal antibody field

(2019) Lien Van Hoecke et al.   Journal of Translational Medicine

Manufacturing chimeric antigen receptor T cells: issues and challenges

(2019) Claire Roddie et al.   CYTOTHERAPY

Taking a "BiTE out of ALL" - Blinautmomab approval for MRD positive ALL

(2019) Emily Curran et al.   BLOOD

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma

(2019) Cesar Sommer et al.   MOLECULAR THERAPY

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

(2018) Gregory L. Beatty et al.   GASTROENTEROLOGY

T cells grafted with HBV-specific T-cell receptors of high functional avidity achieve functional cure of HBV infection in humanized mice

(2018) K. Wisskirchen et al.   JOURNAL OF HEPATOLOGY

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

(2018) Kevin J. Kauffman et al.   Molecular Therapy-Nucleic Acids

Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells

(2018) Pappanaicken R. Kumaresan et al.   Frontiers in Immunology

The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies

(2018) Maja M. Janas et al.   TOXICOLOGIC PATHOLOGY

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

Roadmap and strategy for overcoming infusion reactions to nanomedicines

(2018) Janos Szebeni et al.   Nature Nanotechnology

Allogeneic CAR-T Cells: More than Ease of Access?

(2018) Charlotte Graham et al.   Cells

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

(2017) Janine Kah et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma

(2017) Frederick L. Locke et al.   MOLECULAR THERAPY

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

(2017) Yuri V. Svitkin et al.   NUCLEIC ACIDS RESEARCH

Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey

(2017) Maja Sedic et al.   VETERINARY PATHOLOGY

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

(2017) H. F. Moffett et al.   Nature Communications

FDA Approves Second CAR T-cell Therapy

(2017)   Cancer Discovery

Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants

(2017) Giedre Krenciute et al.   Cancer Immunology Research

Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial

(2016) Chun-Meng Wang et al.   CLINICAL CANCER RESEARCH

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

(2015) Ingunn M. Stromnes et al.   CANCER CELL

T-Cell Therapy: Options for Infectious Diseases: Table 1.

(2015) Shreemanta K. Parida et al.   CLINICAL INFECTIOUS DISEASES

CAR therapy: the CD19 paradigm

(2015) Michel Sadelain   JOURNAL OF CLINICAL INVESTIGATION

Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells

(2015) Julia A.M. Sung et al.   JOURNAL OF CLINICAL INVESTIGATION

Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells

(2015) Dongmei Fan et al.   Journal of Hematology & Oncology

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

(2015) Max S Topp et al.   LANCET ONCOLOGY

Are BiTEs the “missing link” in cancer therapy?

(2015) Carter M Suryadevara et al.   OncoImmunology

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

(2013) T. M. Schmitt et al.   BLOOD

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

(2013) Marina A. Dobrovolskaia et al.   JOURNAL OF CONTROLLED RELEASE

Kinetics of Tumor Destruction by Chimeric Antigen Receptor-modified T Cells

(2013) Usanarat Anurathapan et al.   MOLECULAR THERAPY

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

(2013) Marco L. Davila et al.   PLoS One

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

(2013) Amruta Manke et al.   Biomed Research International

Non-viral gene delivery nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma

(2011) Stephany Y. Tzeng et al.   BIOMATERIALS

Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma

(2011) Ulrike Gerdemann et al.   MOLECULAR THERAPY

Hepatitis B: The virus and disease

(2010) T. Jake Liang   HEPATOLOGY

Blood Cytokines as Biomarkers of In Vivo Toxicity in Preclinical Safety Assessment: Considerations for Their Use

(2010) Jacqueline M. Tarrant   TOXICOLOGICAL SCIENCES

Promising tumor-associated antigens for future prostate cancer therapy

(2009) Yong Li et al.   MEDICINAL RESEARCH REVIEWS

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA