Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Retrogenic Modeling of Experimental Allergic Encephalomyelitis Associates T Cell Frequency but Not TCR Functional Affinity with Pathogenicity

(2014) R. Alli et al.   JOURNAL OF IMMUNOLOGY

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

(2012) Carolina M. Soto et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination

(2011) C. Pospori et al.   BLOOD

Allogeneic HLA-A*02-Restricted WT1-Specific T Cells from Mismatched Donors Are Highly Reactive but Show Off-Target Promiscuity

(2011) W. J. J. Falkenburg et al.   JOURNAL OF IMMUNOLOGY

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

(2010) D. A. Schmid et al.   JOURNAL OF IMMUNOLOGY

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

T Cell Receptor Gene Therapy for Cancer

(2009) Thomas M. Schmitt et al.   HUMAN GENE THERAPY

The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

On the Pathogenicity of Autoantigen-Specific T-Cell Receptors

(2008) A. R. Burton et al.   DIABETES

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Engineering higher affinity T cell receptors using a T cell display system

(2008) Adam S. Chervin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

(2008) Takeshi Egawa et al.   PLoS One