STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Cell Senescence, DNA Damage, and Metabolism

(2020) Riva Shmulevich et al.   ANTIOXIDANTS & REDOX SIGNALING

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

(2020) Abhishek Jauhari et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

(2020) Christina A. von Roemeling et al.   Nature Communications

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

(2020) Mounir El Maï et al.   eLife

DNA-induced 2′3′-cGAMP enhances haplotype-specific human STING cleavage by dengue protease

(2020) Chan-I Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences

(2019) Xuan Song et al.   JOURNAL OF NEUROSCIENCE

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

(2019) Vinod Tiwari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cartilage and Bone Destruction in Arthritis: Pathogenesis and Treatment Strategy: A Literature Review

(2019) Tateiwa et al.   Cells

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis

(2018) Marta Varela-Eirin et al.   AGEING RESEARCH REVIEWS

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sargassum serratifolium Extract Attenuates Interleukin-1β-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-κB, p38 MAPK, and PI3K/Akt

(2018) Cheol Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

DNA damage-induced immune response: Micronuclei provide key platform

(2017) Nelson O. Gekara   JOURNAL OF CELL BIOLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Osteoarthritis year in review 2016: clinical

(2017) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

(2017) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel NF-κB inhibitors: a patent review (2011 – 2014)

(2015) Sateesh Kumar Arepalli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

(2011) J.S. Lewis et al.   OSTEOARTHRITIS AND CARTILAGE

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway

(2011) Azadeh Montaseri et al.   PLoS One

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig

(2010) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

(2009) M. Blagojevic et al.   OSTEOARTHRITIS AND CARTILAGE

Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis

(2007) C.M. Davies et al.   OSTEOARTHRITIS AND CARTILAGE