Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

Antibody binding and complement-mediated killing of invasive Haemophilus influenzae isolates from Spain, Portugal, and the Netherlands

(2020) Elena Dudukina et al.   INFECTION AND IMMUNITY

Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation

(2019) Marjolein M. P. Oerlemans et al.   INFECTION AND IMMUNITY

Serum IgM and C-reactive protein binding to phosphorylcholine of non-typeable Haemophilus influenzae increases complement-mediated killing

(2019) Jeroen D. Langereis et al.   INFECTION AND IMMUNITY

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

(2019) Preston S. K. Ng et al.   mBio

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

(2019) Kunio Kawanishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc

(2019) Chirag Dhar et al.   Frontiers in Immunology

Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

(2019) Heinz Läubli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Underlying glycans determine the ability of sialylated lipooligosaccharide to protect nontypeable Haemophilus influenzae from serum IgM and complement

(2019) Mary Darby Jackson et al.   INFECTION AND IMMUNITY

The antibody/microbiota interface in health and disease

(2019) Delphine Sterlin et al.   Mucosal Immunology

Chemoenzymatic Assembly of Mammalian O-Mannose Glycans

(2018) Caicai Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

(2018) Pamela Ferretti et al.   Cell Host & Microbe

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk

(2018) Annie N. Samraj et al.   PLoS One

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera

(2018) Frederico Alisson-Silva et al.   PLoS Pathogens

Interrelation of Diet, Gut Microbiome, and Autoantibody Production

(2018) Ioanna Petta et al.   Frontiers in Immunology

Identification of a Kdn biosynthesis pathway in the haptophytePrymnesium parvumsuggests widespread sialic acid biosynthesis among microalgae

(2018) Ben A Wagstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution

(2018) Jonathan Okerblom et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nontypeable Haemophilus influenzae Lipooligosaccharide Expresses a Terminal Ketodeoxyoctanate In Vivo, Which Can Be Used as a Target for Bactericidal Antibody

(2018) Michael A. Apicella et al.   mBio

Evolution of the exclusively human pathogen Neisseria gonorrhoeae : Human-specific engagement of immunoregulatory Siglecs

(2018) Corinna S. Landig et al.   Evolutionary Applications

The role of gonococcal Neisserial surface protein A (NspA) in serum resistance and comparison of its factor H binding properties with that of its meningococcal counterpart

(2018) Lisa A. Lewis et al.   INFECTION AND IMMUNITY

Non-typeable Haemophilus influenzae invasive blood isolates are mainly phosphorylcholine negative and show decreased complement-mediated killing in comparison to colonizing isolates from the oropharynx, which is associated with lower binding of IgM and CRP to the bacterial surface

(2018) Jeroen D. Langereis et al.   INFECTION AND IMMUNITY

Enlisting commensal microbes to resist antibiotic-resistant pathogens

(2018) James W. Keith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

(2017) Eric Sterner et al.   Cell Reports

Defining Natural Antibodies

(2017) Nichol E. Holodick et al.   Frontiers in Immunology

A versatile assay to determine bacterial and host factors contributing to opsonophagocytotic killing in hirudin-anticoagulated whole blood

(2017) Erika van der Maten et al.   Scientific Reports

Combined Bacteria Microarray and Quartz Crystal Microbalance Approach for Exploring Glycosignatures of Nontypeable Haemophilus influenzae and Recognition by Host Lectins

(2016) Ioanna Kalograiaki et al.   ANALYTICAL CHEMISTRY

Cell wall glycopolymers of Streptomyces albus, Streptomyces albidoflavus and Streptomyces pathocidini

(2016) Alexander S. Shashkov et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Sialic acid acquisition in bacteria-one substrate, many transporters

(2016) G. H. Thomas   BIOCHEMICAL SOCIETY TRANSACTIONS

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR

(2016) Karina Hentrich et al.   Cell Host & Microbe

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Biochemical Characterization of Bifunctional 3-Deoxy-β-d-manno-oct-2-ulosonic Acid (β-Kdo) Transferase KpsC fromEscherichia coliInvolved in Capsule Biosynthesis

(2016) Olga G. Ovchinnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence ofSIGLEC9polymorphisms on COPD phenotypes including exacerbation frequency

(2016) Takeo Ishii et al.   RESPIROLOGY

Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens

(2016) Eric G. Pamer   SCIENCE

Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae

(2016) Sandy M. Wong et al.   Frontiers in Cellular and Infection Microbiology

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

LC–MS/MS glycomic analyses of free and conjugated forms of the sialic acids, Neu5Ac, Neu5Gc and KDN in human throat cancers

(2015) Fang Wang et al.   GLYCOBIOLOGY

Symbol Nomenclature for Graphical Representations of Glycans

(2015) Ajit Varki et al.   GLYCOBIOLOGY

Carbohydrate structure database merged from bacterial, archaeal, plant and fungal parts

(2015) Philip V. Toukach et al.   NUCLEIC ACIDS RESEARCH

Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

(2015) Sunita Gulati et al.   PLoS Pathogens

Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc

(2014) Stevan A. Springer et al.   IMMUNOGENETICS

Haemophilus influenzae Interacts with the Human Complement Inhibitor Factor H

(2014) T. Hallstrom et al.   JOURNAL OF IMMUNOLOGY

Binding of human factor H to outer membrane protein P5 of non-typeableHaemophilus influenzaecontributes to complement resistance

(2014) Jeroen D. Langereis et al.   MOLECULAR MICROBIOLOGY

A red meat-derived glycan promotes inflammation and cancer progression

(2014) Annie N. Samraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

(2014) Preston S.K. Ng et al.   Nature Communications

Oral Streptococci Utilize a Siglec-Like Domain of Serine-Rich Repeat Adhesins to Preferentially Target Platelet Sialoglycans in Human Blood

(2014) Lingquan Deng et al.   PLoS Pathogens

The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin — a review of its biosynthesis, function, and placement in the lipopolysaccharide core

(2013) Jolanta Lodowska et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Conservation of the 2-keto-3-deoxymanno-octulosonic acid (Kdo) biosynthesis pathway between plants and bacteria

(2013) Kevin M. Smyth et al.   CARBOHYDRATE RESEARCH

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

(2013) Takashi Angata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isolation and characterization of lipid rafts inEmiliania huxleyi: a role for membrane microdomains in host-virus interactions

(2013) Suzanne L. Rose et al.   ENVIRONMENTAL MICROBIOLOGY

Novel molecular determinants of viral susceptibility and resistance in the lipidome ofEmiliania huxleyi

(2013) James M. Fulton et al.   ENVIRONMENTAL MICROBIOLOGY

Outer Membrane Protein P5 Is Required for Resistance of Nontypeable Haemophilus influenzae to Both the Classical and Alternative Complement Pathways

(2013) Charles V. Rosadini et al.   INFECTION AND IMMUNITY

Relative Contributions of Lipooligosaccharide Inner and Outer Core Modifications to Nontypeable Haemophilus influenzae Pathogenesis

(2013) Pau Morey et al.   INFECTION AND IMMUNITY

d-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial

(2013) Bojana Kranjčec et al.   WORLD JOURNAL OF UROLOGY

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Metabolism of Vertebrate Amino Sugars withN-Glycolyl Groups

(2012) Kalyan Banda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-comparison of Protein Recognition of Sialic Acid Diversity on Two Novel Sialoglycan Microarrays

(2012) Vered Padler-Karavani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

TheAspergillus fumigatusSialidase Is a 3-Deoxy-d-glycero-d-galacto-2-nonulosonic Acid Hydrolase (KDNase)

(2011) Judith C. Telford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Infant-associated Bacterial Commensal Utilizes Breast Milk Sialyloligosaccharides

(2011) David A. Sela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green algae Chlamydomonas reinhardtii possess endogenous sialylated N-glycans

(2011) Tarlan Mamedov et al.   FEBS Open Bio

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Insights into the evolution of sialic acid catabolism among bacteria

(2009) Salvador Almagro-Moreno et al.   BMC EVOLUTIONARY BIOLOGY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

(2009) A. L. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Symbiont Bacteroides thetaiotaomicron Synthesizes 2-Keto-3-Deoxy-D-Glycero-D- Galacto-Nononic Acid (KDN)

(2008) Liangbing Wang et al.   CHEMISTRY & BIOLOGY