Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

Mechanism of allosteric inhibition in the Plasmodiumfalciparum cGMP-dependent protein kinase

(2020) Jung Ah Byun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

(2020) Yuanyuan Jiang et al.   Nature Communications

Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes

(2020) Aditya S. Paul et al.   Nature Communications

Phosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform

(2019) Hugo Bisio et al.   Nature Microbiology

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signalling and motility in Toxoplasma gondii

(2019) Luning Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

(2019) Avnish Patel et al.   PLOS BIOLOGY

Structure and autoregulation of a P4-ATPase lipid flippase

(2019) Milena Timcenko et al.   NATURE

Phospholipid flippases in membrane remodeling and transport carrier biogenesis

(2019) Jordan T Best et al.   CURRENT OPINION IN CELL BIOLOGY

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

(2019) Masahiro Hiraizumi et al.   SCIENCE

cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway

(2018) Min Park et al.   BASIC RESEARCH IN CARDIOLOGY

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Uncovering the essential genes of the human malaria parasitePlasmodium falciparumby saturation mutagenesis

(2018) Min Zhang et al.   SCIENCE

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

(2018) James A. Thomas et al.   Nature Microbiology

ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility

(2018) Han Gao et al.   CURRENT BIOLOGY

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase

(2018) Kevin M. Brown et al.   Cell Host & Microbe

Cyclic nucleotide signalling in malaria parasites

(2017) David A. Baker et al.   Open Biology

On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport

(2016) Cédric Montigny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Decoding P4-ATPase substrate interactions

(2016) Bartholomew P. Roland et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite

(2016) Sanketha Kenthirapalan et al.   Nature Communications

A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum

(2016) Matthew L. Jones et al.   Scientific Reports

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum

(2016) James A. Thomas et al.   PLoS One

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs

(2015) Sujaan Das et al.   Cell Host & Microbe

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

(2015) Robert Stallmach et al.   MOLECULAR MICROBIOLOGY

Cyclic GMP Balance Is Critical for Malaria Parasite Transmission from the Mosquito to the Mammalian Host

(2015) Viswanathan Lakshmanan et al.   mBio

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity

(2014) Marijo S. Roiko et al.   PLoS Pathogens

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Spatiotemporal and Functional Characterisation of the Plasmodium falciparum cGMP-Dependent Protein Kinase

(2012) Christine S. Hopp et al.   PLoS One

Pumping lipids with P4-ATPases

(2011) Rosa L. López-Marqués et al.   BIOLOGICAL CHEMISTRY

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development

(2009) Adebola Falae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

(2009) Christine R. Collins et al.   PLoS Pathogens

Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity

(2008) Zongmin Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Flippases: still more questions than answers

(2008) L. R. Poulsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disruption of aPlasmodium falciparumcyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

(2008) Cathy J. Taylor et al.   MOLECULAR MICROBIOLOGY

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY