Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

(2020) Evan J Worden et al.   eLife

Phase separation directs ubiquitination of gene-body nucleosomes

(2020) Laura D. Gallego et al.   NATURE

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

(2020) Jessica L. Kelliher et al.   Nature Communications

The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

(2020) Matteo Berti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation

(2020) Bo Qin et al.   Science Advances

Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks

(2020) Lanni Aquila et al.   Cells

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

(2020) Franziska Walser et al.   MOLECULAR CELL

The role of FACT in managing chromatin: disruption, assembly, or repair?

(2020) Tim Formosa et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

(2019) Cathy J. Anderson et al.   Cell Reports

UFL1 promotes histone H4 ufmylation and ATM activation

(2019) Bo Qin et al.   Nature Communications

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

E3 ubiquitin ligases RNF20 and RNF40 are required for DSB repair: evidence for monoubiquitination of histone H2B lysine 120 as a novel axis of DSB signaling and repair

(2019) Clare C. So et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

(2019) Seongmin Jang et al.   GENES & DEVELOPMENT

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

(2019) Marco Igor Valencia-Sánchez et al.   MOLECULAR CELL

Structural basis of specific H2A K13/K15 ubiquitination by RNF168

(2019) Velten Horn et al.   Nature Communications

The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation

(2019) Hong‐Yeoul Ryu et al.   EMBO JOURNAL

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

(2019) Tarun S. Nambiar et al.   Nature Communications

H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly

(2019) Eriko Oya et al.   EMBO REPORTS

Structural basis of nucleosome recognition and modification by MLL methyltransferases

(2019) Han Xue et al.   NATURE

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases

(2019) Evan J Worden et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2

(2018) Marco Simonetta et al.   CELL CYCLE

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

(2018) Tao Li et al.   NUCLEIC ACIDS RESEARCH

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants

(2018) Felix Wojcik et al.   Nature Communications

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

(2018) Michael Uckelmann et al.   Nature Communications

Principles of Ubiquitin-Dependent Signaling

(2018) Eugene Oh et al.   Annual Review of Cell and Developmental Biology

Examination of the deubiquitination site-selectivity of USP51 using chemically synthesized ubiquitinated histones

(2018) Lei Liu   CHEMBIOCHEM

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

(2018) Jonas Andreas Schmid et al.   MOLECULAR CELL

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

(2018) Liwei An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks

(2018) Sihao Zheng et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

(2017) Chun-Song Yang et al.   MOLECULAR CELL

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

(2017) Qi Hu et al.   MOLECULAR CELL

Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

(2017) Satoshi Ishiyama et al.   MOLECULAR CELL

Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication

(2017) Shih-Hsun Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

(2017) I. K. Mandemaker et al.   Scientific Reports

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

(2017) Stefania Pellegrino et al.   Cell Reports

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

(2017) Julianne Kitevski-LeBlanc et al.   eLife

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

(2016) Zhiquan Wang et al.   GENES & DEVELOPMENT

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

(2016) Boyko S. Atanassov et al.   MOLECULAR CELL

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

(2016) Giulia Saredi et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Stop pulling my strings — what telomeres taught us about the DNA damage response

(2016) Eros Lazzerini-Denchi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

(2016) Yohei Niikura et al.   Cell Reports

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79

(2015) Shoudeng Chen et al.   MOLECULAR CELL

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

Ubiquitin acetylation inhibits polyubiquitin chain elongation

(2014) F. Ohtake et al.   EMBO REPORTS

Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions

(2014) Abhinav Dhall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair

(2014) Tingting Li et al.   JOURNAL OF CELL SCIENCE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

(2014) Francesca Mattiroli et al.   Nature Communications

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

H2B Mono-ubiquitylation Facilitates Fork Stalling and Recovery during Replication Stress by Coordinating Rad53 Activation and Chromatin Assembly

(2014) Chia-Yeh Lin et al.   PLoS Genetics

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

(2014) Justin W. Leung et al.   PLoS Genetics

A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly

(2013) Junhong Han et al.   CELL

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Systematic Identification of Proteins Binding to Chromatin-Embedded Ubiquitylated H2B Reveals Recruitment of SWI/SNF to Regulate Transcription

(2013) Efrat Shema-Yaacoby et al.   Cell Reports

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

(2012) S. B. Chernikova et al.   CANCER RESEARCH

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

(2012) Marco Gatti et al.   CELL CYCLE

Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage

(2012) Jie Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

A Role for H2B Ubiquitylation in DNA Replication

(2012) Kelly M. Trujillo et al.   MOLECULAR CELL

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

(2011) Yu Ye et al.   EMBO REPORTS

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

(2009) Sabrina Pinato et al.   BMC MOLECULAR BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL