Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5′-nucleotidase (CD73) Inhibitors with Variable Binding Modes

(2020) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of the CD39–CD73–adenosine pathway in liver disease

(2020) Sheng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ecto-Nucleotidases CD73 and CD39

(2020) Jenna L. Jeffrey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold

(2020) Saira Afzal et al.   Medicinal Chemistry

Conversion of extracellular ATP into adenosine: a master switch in renal health and disease

(2020) Karen M. Dwyer et al.   Nature Reviews Nephrology

Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

(2019) Anna Junker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73)

(2019) Marquet Minor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CD73: an emerging checkpoint for cancer immunotherapy

(2019) Siqi Chen et al.   Immunotherapy

CD39-adenosinergic axis in renal pathophysiology and therapeutics

(2018) Bellamkonda K. Kishore et al.   Purinergic Signalling

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Purinergic signaling during intestinal inflammation

(2017) Maria Serena Longhi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

(2016) James C. Geoghegan et al.   mAbs

Regulation of the T Cell Response by CD39

(2016) Maisa C. Takenaka et al.   TRENDS IN IMMUNOLOGY

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors

(2015) Sang-Yong Lee et al.   BIOCHEMICAL PHARMACOLOGY

Insights into Ecto-5’-Nucleotidase as a New Target for Cancer Therapy: A Medicinal Chemistry Study

(2015) Patricia Corbelini et al.   CURRENT MEDICINAL CHEMISTRY

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

(2015) Younis Baqi   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

(2014) Gennady G. Yegutkin   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Purinergic Signaling in Liver Disease

(2014) Byron P. Vaughn et al.   DIGESTIVE DISEASES

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Therapeutic Potentials of Ecto-Nucleoside Triphosphate Diphosphohydrolase, Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto-5′-Nucleotidase, and Alkaline Phosphatase Inhibitors

(2013) Mariya al-Rashida et al.   MEDICINAL RESEARCH REVIEWS

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Role of the ectonucleotidase NTPDase2 in taste bud function

(2013) Aurelie Vandenbeuch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic Snapshots along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases

(2013) Matthias Zebisch et al.   STRUCTURE

Crystal Structure of a Soluble Form of Human CD73 with Ecto-5′-Nucleotidase Activity

(2012) Dominic P. H. M. Heuts et al.   CHEMBIOCHEM

Ectonucleotidases in Solid Organ and Allogeneic Hematopoietic Cell Transplantation

(2012) Petya Chernogorova et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape

(2012) François Ghiringhelli et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Superior working memory and behavioural habituation but diminished psychomotor coordination in mice lacking the ecto-5′-nucleotidase (CD73) gene

(2012) Armin Zlomuzica et al.   Purinergic Signalling

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells

(2011) Michael Romio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury

(2011) Ming Cai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crystallographic Evidence for a Domain Motion in Rat Nucleoside Triphosphate Diphosphohydrolase (NTPDase) 1

(2011) Matthias Zebisch et al.   JOURNAL OF MOLECULAR BIOLOGY

The GDA1_CD39 superfamily: NTPDases with diverse functions

(2011) Aileen F. Knowles   Purinergic Signalling

Purinergic signaling in neural development

(2011) Herbert Zimmermann   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adenine nucleotide control of coronary blood flow during exercise

(2010) Mark W. Gorman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases

(2010) Julian P. Vivian et al.   STRUCTURE

Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling

(2008) M. Zebisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP and acetylcholine, equal brethren

(2007) Herbert Zimmermann   NEUROCHEMISTRY INTERNATIONAL