Posttranslational modifications as therapeutic targets for intestinal disorders

KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation

(2020) Haijie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways

(2019) Qiuke Hou et al.   BMC Complementary and Alternative Medicine

Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice

(2019) Keyvan Amirshahrokhi   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

(2019) Minori Kubota et al.   PLoS One

Analgesic effect of resveratrol on colitis-induced visceral pain via inhibition of TRAF6/NF-κB signaling pathway in the spinal cord

(2019) Ying Lu et al.   BRAIN RESEARCH

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3

(2018) Lei Liu et al.   CANCER RESEARCH

Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation

(2018) Davide Di Fusco et al.   CLINICAL SCIENCE

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

(2018) Mirna Šimurina et al.   GASTROENTEROLOGY

Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway

(2018) Li Qiao Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Diseases

(2018) Gillian Dekkers et al.   Frontiers in Immunology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epithelial expression and function of trypsin-3 in irritable bowel syndrome

(2017) Claire Rolland-Fourcade et al.   GUT

ColonicN-methyl-d-aspartate receptor contributes to visceral hypersensitivity in irritable bowel syndrome

(2017) Qingqing Qi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats

(2017) Changchun Yu et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

NF-kappa B activation correlates with disease phenotype in Crohn’s disease

(2017) Yoo Min Han et al.   PLoS One

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

(2017) Ting-Hong Ye et al.   Cell Death & Disease

Modulation of inflammation by toll-like receptor 4/nuclear factor-kappa B in diarrhea-predominant irritable bowel syndrome

(2017) Xing He et al.   Oncotarget

Colitis Is Effectively Ameliorated by (±)-8-Acetonyl-dihydrocoptisine via the XBP1-NF-κB Pathway

(2017) HaiJing Zhang et al.   Frontiers in Pharmacology

14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells

(2016) M Gómez-Suárez et al.   CELL DEATH AND DIFFERENTIATION

IgG Glycome in Colorectal Cancer

(2016) F. Vuckovic et al.   CLINICAL CANCER RESEARCH

Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases

(2016) Sascha Rutz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

(2016) Wen-Jing Liang et al.   Gut and Liver

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

(2016) Dylan K. McDaniel et al.   INFLAMMATORY BOWEL DISEASES

RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease

(2016) Jelle de Wit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways

(2016) Run-Wei Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression

(2016) Richard L Wu et al.   LABORATORY INVESTIGATION

The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population

(2016) Yang Gong et al.   MEDIATORS OF INFLAMMATION

Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis

(2016) Lin Yang et al.   Molecular Medicine Reports

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination

(2016) Mahesh Kathania et al.   NATURE IMMUNOLOGY

The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis

(2016) Kun Ji et al.   PLoS One

Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances

(2016) Gustaw Lech   WORLD JOURNAL OF GASTROENTEROLOGY

Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF–κB, uPA activator and MMP9

(2016) Weihua Tong et al.   Oncology Letters

A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells

(2016) Chongqiang Zhao et al.   Oncotarget

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

(2016) Shenglan Yang et al.   RSC Advances

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

(2016) Mercedes Soares-Silva et al.   Frontiers in Microbiology

Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice

(2016) Shengnan Zhao et al.   Frontiers in Immunology

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Glycosylation of plasma IgG in colorectal cancer prognosis

(2016) Evropi Theodoratou et al.   Scientific Reports

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis

(2016) Shigehiro Itani et al.   Scientific Reports

ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development

(2015) Lekun Fang et al.   CANCER CELL

Genistein Inhibits Human Colorectal Cancer Growth and Suppresses MiR-95, Akt and SGK1

(2015) Jian Qin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

RORγt+hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice

(2015) Maria Martin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway

(2015) Fei Mao et al.   FASEB JOURNAL

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer

(2015) Vineeta Khare et al.   INFLAMMATORY BOWEL DISEASES

The TGF-β/Smad System in IBD Pathogenesis

(2015) Silvia Sedda et al.   INFLAMMATORY BOWEL DISEASES

1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway

(2015) Jie Du et al.   INFLAMMATORY BOWEL DISEASES

A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation

(2015) Yiwen Bu et al.   INTERNATIONAL JOURNAL OF CANCER

Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review

(2015) Emanual Maverakis et al.   JOURNAL OF AUTOIMMUNITY

Synthesis and Structure–Activity Relationships of Quaternary Coptisine Derivatives as Potential Anti-ulcerative Colitis Agents

(2015) Zhi-Hui Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

(2015) Manfred Wuhrer et al.   Journal of Neuroinflammation

NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis

(2015) Hua Wu et al.   JOURNAL OF PATHOLOGY

Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats

(2015) ZAIFENG YI et al.   Molecular Medicine Reports

Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway

(2015) Xiang-An Zhang et al.   Pharmacognosy Magazine

The PI3K-PKB/Akt Pathway

(2015) Brian A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Natural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination

(2015) Ke-Wu Zeng et al.   Scientific Reports

Increased production of BDNF in colonic epithelial cells induced by fecal supernatants from diarrheic IBS patients

(2015) Peng Wang et al.   Scientific Reports

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer

(2014) K Malinowsky et al.   BRITISH JOURNAL OF CANCER

Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab

(2014) E Zulato et al.   BRITISH JOURNAL OF CANCER

Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis

(2014) Gowrikumar Saiprasad et al.   EUROPEAN JOURNAL OF CANCER

Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways

(2014) Jin-Ju Jeong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stat3

(2014) Jie Han et al.   INFLAMMATORY BOWEL DISEASES

Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis

(2014) Hoa T. Tran et al.   INFLAMMATORY BOWEL DISEASES

Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53

(2014) Junzhe Jin et al.   International Journal of Biological Sciences

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6

(2014) T Watanabe et al.   Mucosal Immunology

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

(2014) Sascha Rutz et al.   NATURE

Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine

(2014) Lekha Saha   WORLD JOURNAL OF GASTROENTEROLOGY

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

RORγt Modulators Are Potentially Useful for the Treatment of the Immune-Mediated Inflammatory Diseases

(2014) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes

(2014) Sanja A Farkas et al.   Epigenomics

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

Protease-Activated Receptors as Therapeutic Targets in Visceral Pain

(2013) Nicolas Cenac   Current Neuropharmacology

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis

(2013) Georgios Koukos et al.   GASTROENTEROLOGY

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Non-canonical ubiquitylation: Mechanisms and consequences

(2013) Gary S. McDowell et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer

(2013) Seong-Joon Koh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease

(2013) Jun Shen et al.   MEDIATORS OF INFLAMMATION

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2

(2013) Patricia R Taylor et al.   NATURE IMMUNOLOGY

Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS

(2013) E. Wilcz-Villega et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway

(2013) Min Cao et al.   PLoS One

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation

(2013) Peng Sun et al.   PLoS One

Targeting inflammation and wound healing by opioids

(2013) Christoph Stein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anti-cancer potential of flavonoids: recent trends and future perspectives

(2013) Priya Batra et al.   3 Biotech

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Impact of STAT3 Phosphorylation on the Clinical Effectiveness of Anti-EGFR–Based Therapy in Patients With Metastatic Colorectal Cancer

(2012) Erion Dobi et al.   Clinical Colorectal Cancer

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Myosin Light Chain Kinase Inhibitor Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice

(2012) Xiaochang Liu et al.   DIGESTIVE DISEASES AND SCIENCES

Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR

(2012) Jinsong Peng et al.   DRUG AND ALCOHOL DEPENDENCE

STAT3 repressed USP7 expression is crucial for colon cancer development

(2012) Yang Zhi et al.   FEBS LETTERS

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis

(2012) Kirstin Reinecke et al.   PLoS One

Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

(2012) Athina Stravodimou et al.   PPAR Research

Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeability

(2011) Tamia K. Lapointe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

Black tea extract prevents lipopolysaccharide-induced NF-κB signaling and attenuates dextran sulfate sodium-induced experimental colitis

(2011) Young-A Song et al.   BMC Complementary and Alternative Medicine

Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells

(2011) RC Dutra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of epithelial STAT3 regulates intestinal homeostasis

(2011) Clemens Neufert et al.   CELL CYCLE

Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells

(2011) Chun-Chuan Chen et al.   CLINICAL IMMUNOLOGY

The Expression of Protease-Activated Receptor 2 and 4 in the Colon of Irritable Bowel Syndrome Patients

(2011) Ju-hui Zhao et al.   DIGESTIVE DISEASES AND SCIENCES

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Brain-derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome

(2011) Yan-Bo Yu et al.   GUT

Meta-analysis of new genome-wide association studies of colorectal cancer risk

(2011) Ulrike Peters et al.   HUMAN GENETICS

PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis

(2011) Xiao Li Huang et al.   INFLAMMATION RESEARCH

NF-κB p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients

(2011) Andreas Lewander et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

(2011) Ruiying Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ

(2011) H H Choi et al.   ONCOGENE

Twists and turns in ubiquitin-like protein conjugation cascades

(2011) Brenda A. Schulman   PROTEIN SCIENCE

The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status

(2011) Martin Kruschewski et al.   Cancers

Interleukin-17-producing T helper cells in autoimmunity

(2010) Nasr YA. Hemdan et al.   AUTOIMMUNITY REVIEWS

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

(2010) Y Baba et al.   BRITISH JOURNAL OF CANCER

Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease

(2010) G. Docena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Galactosylation of Serum IgA1 O-Glycans in Celiac Disease

(2010) Katri Lindfors et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Hydrogen Sulphide Induces μ Opioid Receptor-Dependent Analgesia in a Rodent Model of Visceral Pain

(2010) Eleonora Distrutti et al.   Molecular Pain

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

(2009) Moïse Coëffier et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

(2009) M P Charalambous et al.   BRITISH JOURNAL OF CANCER

The nuclear signaling of NF-κB: current knowledge, new insights and future perspectives

(2009) Fengyi Wan et al.   CELL RESEARCH

The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease

(2009) S. Inoue et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth

(2009) K. Sakamoto et al.   CLINICAL CANCER RESEARCH

Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPAR  downregulation in intestinal epithelial cells and coeliac mucosa

(2009) A. Luciani et al.   GUT

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients

(2009) Zhao Xiang Bian et al.   JOURNAL OF GASTROENTEROLOGY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE

FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice

(2008) Takashi Nishimura et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

(2008) Peter Laszlo Lakatos et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES