Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wei-ping Hu, Liang Xie, Sheng-yu Hao, Qin-han Wu, Gui-ling Xiang, Shan-qun Li, Dong Liu
Summary: In this study, it was found that progesterone played a protective role on human pulmonary artery smooth muscle cells under inflammation by blocking the functions of STAT3. This could help explain the better prognosis for women with PAH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shenglin Wang, Yunqing Wang, Zhen Huang, Hongxiang Wei, Xinwen Wang, Rongkai Shen, Wenbin Lan, Guangxian Zhong, Jianhua Lin
Summary: This study confirms the moderate anti-tumor effects of gefitinib on osteosarcoma, via suppression of the PI3K/Akt and ERK pathways to reduce cell proliferation and migration. Combined treatment with stattic further enhances the inhibitory effects of gefitinib, reducing cell invasion and promoting apoptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Shi-Yu Wang, Jin-Hai Jiang, Si-Yuan Liu, Jie Zhang, Xiang Gao, Hang Liu, Kai-Xin Ke, Yue Jiang, Lu Liu, Bai-Cheng He
Summary: IL-6 plays a dual role in regulating bone metabolism, and its relationship with BMP9 in osteogenic differentiation needs further investigation. BMP9 can upregulate IL-6 and its osteoblastic markers in mouse embryonic fibroblasts (MEFs), but this effect is reduced when IL-6 is knocked down. The promotion of BMP9 osteoblastic potential by IL-6 may be mediated through activating Stat-3/mTORC1 pathway.
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Meng-Yao Wu, Yu-Xin Luo, Wen-Xiu Jia, Dan-Dan Wang, Dong-Lei Sun, Jia Song, Jing Wang, Wei-Wei Niu, Xiao-Lan Zhang
Summary: The study found that miRNA-320 inhibits tumorigenesis in mice with CAC by suppressing IL-6R/STAT3 expression.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Summary: Th17 cells play a significant role in the pathogenesis of myocarditis, and Bazedoxifene can affect STAT3 signaling to effectively inhibit the progression of cardiac inflammation. Therefore, Bazedoxifene may be a promising therapeutic strategy for the treatment of experimental autoimmune myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Danfei Liu, Xiangyuan Luo, Meng Xie, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Yijun Wang, Yangyang Feng, Xiaoyu Ji, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xia
Summary: The study reveals the clinical value, functional role, and molecular mechanism of heterogeneous nuclear ribonucleoprotein C (HNRNPC) in hepatocellular carcinoma (HCC), highlighting its potential as a biomarker for diagnosis, prognosis, and therapeutic targets.
Article
Integrative & Complementary Medicine
Chun-lei Zheng, Ke-zuo Hou, An-qi Wang, Wan-xia Fang, Shi-tong Yu, Jin-e Liang, Hai-yan Qi, Xiu-juan Qu, Yun-peng Liu, Xiao-fang Che
Summary: The study found that KAI exerts anti-proliferative effects in gastric cancer cells by inhibiting the IL-6/STAT3 signaling pathway and inducing G1 phase arrest.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Tadashi Matsuda
Summary: The IL-6 family of cytokines uses the common beta-receptor signaling subunit gp130 to promote various signals. They have diverse effects on different cell types, including immune and inflammatory cells, and also have hormone-like features involved in homeostasis. The signaling molecule STAT3 is crucial in regulating IL-6/gp130 and is highly implicated in pathological conditions. This review focuses on IL-6-mediated signal transduction and introduces novel proteins that interact with STAT3, which can aid in developing strategies to clinically control IL-6/STAT3 functions.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biology
Weikang Luo, Ruoqi Ding, Xiaohang Guo, Tao Zhan, Tao Tang, Rong Fan, Yang Wang
Summary: This study identified potential Chinese medicine formulas for moderate COVID-19 patients through clinical data mining and network pharmacology methods. Among them, the Gancao-Banxia herbal pair was considered the most promising. Bioinformatic data demonstrated that Gancao-Banxia may achieve dual inhibition of IL-6-STAT3 by directly interacting with IL-6 and STAT3, suppressing the IL-6 amplifier.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Jingwen Jiang, Fengting Zhu, Hui Zhang, Tao Sun, Fangfang Fu, Xuewu Chen, Yanhong Zhang
Summary: This study found that luteolin suppresses the growth and migration/invasion potential of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Cell Biology
Dandan Gu, Qiong Nan, Yinglei Miao, Hailong Yang, Maojuan Li, Yan Ye, Jiarong Miao
Summary: This study found that KT2 alleviates ulcerative colitis by repressing Th17 cell differentiation through the miR-302c-5p/STAT3 axis.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Siru Zhou, Qinggang Dai, Xiangru Huang, Anting Jin, Yiling Yang, Xinyi Gong, Hongyuan Xu, Xin Gao, Lingyong Jiang
Summary: The study found that inactivation of STAT3 in osteoblasts can induce AD-HIES-like skeletal defects, while pharmacological activation of STAT3 can rescue this phenotype. STAT3 cooperates with MSX1 to drive osteoblast differentiation, indicating the importance of STAT3 in modulating skeletal development and maintaining bone homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Kosuke Miyauchi, Sewon Ki, Masao Ukai, Yoshie Suzuki, Kentaro Inoue, Wataru Suda, Takeshi Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko J. Tanaka, Mariko Okada-Hatakeyama, Masato Kubo
Summary: The study suggests that STAT3 signaling in keratinocytes is essential for maintaining skin homeostasis by negatively regulating the expression of hair follicle-specific keratin genes. Expression patterns associated with dermatitis onset were observed under specific conditions, indicating the involvement of Toll-like receptor-mediated inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Bing Zheng, Xingtao Zhou, Xiaobo Hu, Yi Chen, Jianhua Xie, Qiang Yu
Summary: Polysaccharides have various biological activities, making them a potential natural drug for treating diseases. Apoptosis and autophagy play important roles in human health, and the regulation of apoptosis and autophagy by polysaccharides varies in different disease models. This review summarizes the relationship between apoptosis/autophagy and common human diseases, and discusses the role of apoptosis/autophagy pathway in regulating human health by polysaccharides.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Jiawen Lu, Ying Yang, Elisabeth Varga, Doris Marko, Qiang Yu, Jianhua Xie, Chang Li, Yi Chen
Summary: This study used RNA-Seq to screen the MAPK signaling pathway as one of the crucial pathways for PSG-F-2 pretreatment against AA-induced damage in IEC-6 cells. Western blot and immunofluorescence confirmed the RNA-Seq data, and revealed that PSG-F-2 protects intestinal cells from AA-induced damage through the MAPK/ERK signaling pathway. The findings suggest that PSG-F-2 can be used as a daily dietary supplement to protect intestinal cells from thermal processing hazards caused by AA.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Article
Biochemistry & Molecular Biology
Shuping Chen, Junqiao Wang, Nan Dong, Qiuyue Fang, Yanli Zhang, Chunhua Chen, Steve W. W. Cui, Shaoping Nie
Summary: Polysaccharides from Cordyceps sinensis showed promising effects on experimental acute ulcerative colitis in mice. They alleviated colitis symptoms, inhibited NF-kappa B pathway activation, and modulated the gut microbiota composition. These findings suggest that Cordyceps sinensis polysaccharides have potential as a treatment for ulcerative colitis.
Article
Medicine, General & Internal
Quanjiang Li, Qiang Yu, Beibei Gong, Youquan Ning, Xinwei Chen, Jinming Gu, Fajin Lv, Juan Peng, Tianyou Luo
Summary: The study aimed to develop radiomics models based on MR images to distinguish early-stage and advanced-stage nasopharyngeal carcinoma (NPC). Seven radiomics models were constructed using data from 329 patients. Model A (including contrast-enhanced T1WI, T1WI, and T2WI images) showed the best classification performance in the training cohort, effectively distinguishing early-stage from advanced-stage NPC patients. This study is of great importance for improving the accuracy of NPC staging and treatment.
Article
Agriculture, Multidisciplinary
Tongwen Huang, Ke Zhang, Junqiao Wang, Kaihong He, Xingtao Zhou, Shaoping Nie
Summary: This study found that quercetin can alleviate the hepatotoxicity caused by acrylamide generated in heat-treated foods. Experiments on mice showed that quercetin can reduce the oxidative stress levels induced by acrylamide and protect the liver from damage. The results demonstrated that quercetin suppressed acrylamide-induced ferroptosis by inhibiting oxidative stress-driven autophagy, leading to the mitigation of liver injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jinjin Liu, Junyi Yin, Xiaojun Huang, Cencen Liu, Liuyun Hu, Yansheng Huang, Fang Geng, Shaoping Nie
Summary: This study aimed to remove the controversial anthraquinones from Cassia obtusifolia seed water extracts (CWEs) using baking treatment (BT), stir-frying treatment (ST), and adsorption treatment (AT). Results showed that AT had the best removal effect on total anthraquinones and increased the content of neutral sugars in CWEs. However, AT decreased the antioxidant activity of CWEs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Dan Su, Jiawen Lu, Chunchao Nie, Ziyan Guo, Chang Li, Qiang Yu, Jianhua Xie, Yi Chen
Summary: This study aimed to investigate the effects of AA and OTA individually and collectively on Caco-2 cells. The results showed that AA and OTA significantly inhibited Caco-2 cell viability, decreased TEER values, and increased LY permeabilization, LDH release, and ROS levels. Furthermore, AA and OTA treatment led to increased levels of IL-1 beta, IL-6, and TNF-alpha, while IL-10 levels decreased. Western blot analysis revealed that AA and OTA damaged the intestinal barrier by reducing the expression of tight junction proteins.
Article
Food Science & Technology
Xin Wang, Liyuan Rong, Mingyue Shen, Qiang Yu, Yi Chen, Jinwang Li, Jianhua Xie
Summary: This study investigated the effects of four food supplements (vitamins, minerals, salt, and sugar) on swallowing characteristics and food properties for dysphagia patients. The results showed that all samples belonged to level 4 in the IDDSI framework and exhibited shear thinning behavior, which is beneficial for dysphagia patients. The sensory evaluation demonstrated that dysphagia foods made with rice starch, perilla seed oil, and whey isolate protein, combined with both vitamins and 0.5% salt and sugar, scored the highest.
Article
Food Science & Technology
Yuzhen Hong, Mingyue Shen, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The aim of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in mice. The results showed that MP could alleviate liver injury and promote the production of short chain fatty acids (SCFAs).
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biotechnology & Applied Microbiology
Hao Zhang, Chunhua Chen, Yanli Zhang, Hongmei Yin, Jielun Hu, Yadong Zhong, Shaoping Nie, Mingyong Xie
Summary: This study comprehensively investigated and compared the fermentation characteristics of indigestible glucans (IGs) with different structural properties and their effects on the gut microbiota. The results showed that different IGs were utilized by the gut microbiota at varying rates, and some remained unfermented after 48 hours. During fermentation, IGs released mono-, di-, or trisaccharides and lowered the pH of the broth, while producing short-chain fatty acids. The analysis also revealed that different IGs selectively promoted the proliferation of specific bacteria in the gut.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Shanshan Zhang, Yonggan Sun, Qixing Nie, Jielun Hu, Wenwen Su, Zheyu Guo, Yanli Zhang, Shaoping Nie
Summary: Polysaccharides are commonly used as carriers for colon-targeted drugs, but their degradation and effects on gut microbiota in colitis conditions are unclear. In this study, the fermentation of four polysaccharides using colonic content microbiota from mice with colitis was performed. The results show that pectin and guar gum have a greater degree of degradation and promote the production of beneficial bacteria, while carrageenan and xanthan gum promote the proliferation of harmful bacteria.
Article
Chemistry, Multidisciplinary
Anqi Xie, Haihua Ji, Zheyi Liu, Yiqun Wan, Xuecong Zhang, Huihuang Xiong, Shao-Ping Nie, Hao Wan
Summary: Oral administration of probiotics is a promising method to alleviate inflammatory bowel diseases (IBDs), but sensitivity to the gastrointestinal environment and poor intestinal colonization hinder their effectiveness. In this study, a modified prebiotic-based shield (Fe-TA@mGN) was developed to enhance the stress resistance ability and intestinal colonization of Escherichia coli Nissle 1917 (EcN). The shield improved the survival rate of EcN and its retention in the intestine, leading to efficient alleviation of colitis. Additionally, the shield synergized with EcN to regulate gut microbiota and promote the production of short-chain fatty acids, further enhancing the alleviation of colitis.
Article
Food Science & Technology
Jie Tang, Chaoran Yang, Xiaoting Qin, Jingyu Si, Xuewen Dong, Xiaobo Hu, Qiang Yu
Summary: A cellulose degrading strain (Penicillium griseofulvum) was used to ferment and modify soluble dietary fiber (SDF) extracted from Citrus aurantium L. (CAL). The fermentation process improved the structure characteristics and adsorption properties of CAL-SDF, resulting in an increased SDF yield. The modified SDF showed improved thermal stability, water solubility, and adsorption capacities. The study suggests that Penicillium griseofulvum can be used as a potential strain for modifying CAL-SDF to enhance its functional properties. Overall, the modification process has significant potential in increasing the value proposition of CAL. Evaluation: 8 out of 10.
Article
Food Science & Technology
Xiaoting Qin, Xuewen Dong, Jie Tang, Yi Chen, Jianhua Xie, Yanan Cheng, Bing Zheng, Xiaobo Hu, Qiang Yu
Summary: Ultrafine grinding treatment was used to process grapefruit peel, and the structural properties and adsorption capacities of extracted soluble dietary fibers (SDFs) were comparatively analyzed. The results showed that ultrafine grinding treatment reduced the crystallinity and thermal stability of SDFs, while increasing the pectin content. SDFs treated with ultrafine grinding were found to promote bacterial proliferation and stimulate the production of short-chain fatty acids by probiotic strains.
