Decreased KLHL3 expression is involved in the activation of WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling

(2019) Kenichi Ishizawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice

(2019) Kenichi Ishizawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus

(2019) Trevor P. Fidler et al.   DIABETES

MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling

(2019) Rui Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling

(2019) Suji Han et al.   Cancers

An Update on Hypertension in Children With Type 1 Diabetes

(2018) Mallory L. Downie et al.   Canadian Journal of Diabetes

Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo

(2018) Sayaka Yoshida et al.   Clinical and Experimental Nephrology

Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel

(2018) Ming-Xiao Wang et al.   KIDNEY INTERNATIONAL

Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent

(2018) Cary R. Boyd-Shiwarski et al.   MOLECULAR BIOLOGY OF THE CELL

Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway

(2018) Ryan J. Cornelius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3

(2017) Emi Sasaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases

(2016) Juliette Hadchouel et al.   Annual Review of Physiology

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3

(2015) Yuki Yoshizaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

(2015) Andrew S. Terker et al.   Cell Metabolism

Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy

(2015) Rui Ni et al.   DIABETES

Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder

(2015) Eisei Sohara et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer

(2015) Ping Chen et al.   Oncotarget

Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association

(2014) Sarah D. de Ferranti et al.   DIABETES CARE

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice

(2014) Koichiro Susa et al.   HUMAN MOLECULAR GENETICS

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation

(2014) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin increases the functional activity of the renal NaCl cotransporter

(2013) María Chávez-Canales et al.   JOURNAL OF HYPERTENSION

Phosphorylation Regulates NCC Stability and Transporter Activity In Vivo

(2013) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

Enhanced phosphorylation of Na+–Cl−co-transporter in experimental metabolic syndrome: role of insulin

(2012) Radko Komers et al.   CLINICAL SCIENCE

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

(2012) Hidenori Nishida et al.   HYPERTENSION

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule

(2010) Nis B. Pedersen et al.   KIDNEY INTERNATIONAL

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

(2009) David J. Rozansky et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL