Article
Biochemistry & Molecular Biology
Dulce Maria Delgadillo, Adriana Ivonne Cespedes-Cruz, Emmanuel Rios-Castro, Maria Guadalupe Rodriguez Maldonado, Mariel Lopez-Nogueda, Miguel Marquez-Gutierrez, Rocio Villalobos-Manzo, Lorena Ramirez-Reyes, Misael Dominguez-Fuentes, Jose Tapia-Ramirez
Summary: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease that is often misdiagnosed. This study provides further insights into the molecular and proteomic analysis of ALPS by studying peripheral blood mononuclear cells (PBMCs) from two ALPS patients, and highlights potential mechanisms involved in the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jasmin H. Shahinian, Cosima B. Hauser-Stadler, Tim Walter, Philipp Discher, Ines Derya Steenbuck, Oliver Schilling, Martin Czerny
Summary: This study demonstrates the applicability of serum proteomics in the investigation of aortic diseases and highlights the potential to establish disease-specific prognostic markers.
Article
Multidisciplinary Sciences
Meimei Chen, Zhaoyang Yang, Huijian Gan, Yang Wang, Chandong Li, Yuxing Gao
Summary: This study conducted an integrated analysis of proteomic and metabonomic data to investigate the potential mechanisms of metabolic syndrome and identified several shared metabolic pathways between metabolic syndrome and diabetes. The study also found differential metabolites and proteins that are closely associated with metabolic processes and biosynthetic processes. Additionally, potential drugs for metabolic syndrome were suggested through database searching and molecular docking.
Article
Biochemistry & Molecular Biology
Yehuda M. Danino, Lena Molitor, Tamar Rosenbaum-Cohen, Sebastian Kaiser, Yahel Cohen, Ziv Porat, Hagai Marmor-Kollet, Corine Katina, Alon Savidor, Ron Rotkopf, Eyal Ben-Isaac, Ofra Golani, Yishai Levin, David Monchaud, Ian D. Hickson, Eran Hornstein
Summary: This study reveals a novel role of Bloom's syndrome protein in the regulation of cytoplasmic processes. It demonstrates that BLM can unwind RNA G-quadruplexes and acts as a negative regulator of stress granule formation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Zhuochao Zhou, Yijun You, Fan Wang, Yue Sun, Jialin Teng, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Qiongyi Hu, Huihui Chi, Jinchao Jia, Liyan Wan, Tingting Liu, Mengyan Wang, Ce Shi, Chengde Yang, Junna Ye
Summary: The study found that urinary levels of CXCL12 and PDGFB could serve as potential non-invasive markers to differentiate primary TAPS from primary OAPS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Candela Castillo-Felipe, Lorena Franco-Martinez, Asta Tvarijonaviciute, Pia Lopez-Jornet, Elsa Lamy
Summary: Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Proteomic analysis of saliva from BMS patients reveals alterations in proteins related to stress, immune system, and inflammation, suggesting their involvement in BMS development. Saliva may serve as a valuable biofluid for studying and diagnosing BMS.
Article
Genetics & Heredity
Urszula Smyczynska, Marcin Stanczak, Miljan Kuljanin, Aneta Wlodarczyk, Ewelina Stoczynska-Fidelus, Joanna Taha, Bartlomiej Pawlik, Maciej Borowiec, Joseph D. D. Mancias, Wojciech Mlynarski, Piotr Rieske, Wojciech Fendler, Agnieszka Zmyslowska
Summary: This study conducted transcriptomic and proteomic analysis on cellular models of Alstrom syndrome and Bardet-Biedl syndrome, identifying common and distinct pathological mechanisms between the two syndromes. Genes related to lipid and glycosaminoglycan metabolism and small molecule transport were downregulated, while those associated with signal transduction, immune system, cell cycle control, and DNA replication and repair were upregulated. Protein pathways involved in autophagy, apoptosis, cilium assembly, and Gli1 protein were also upregulated in both syndromes.
Review
Biochemistry & Molecular Biology
Ting-Wei Kao, Chin-Chou Huang
Summary: Metabolic syndrome is a challenging disease with increasing incidence and diverse affected populations, requiring thorough investigation. Recent studies have shown differential expression of substances in MetS, as well as the influence of diet and exercise on energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartlomiej Pawlik, Magdalena Lebiedzinska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski, Wojciech Fendler
Summary: The study evaluated protein levels and gene transcription changes in a human WFS cell model under experimental ER stress. Proteomic analysis revealed differences in specific signal pathways and down-regulation of respiratory chain subunits in NSC WFS cells, with up-regulation of proteins related to Krebs cycle and glycolysis. Pathway enrichment analysis showed significant down-regulation of mitochondrial protein import machinery and OXPHOS in mice hippocampi samples with WFS1 deficiency.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Miji Shin, Sang Hyun Park, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Acute coronary syndrome (ACS) is a condition where the coronary artery is obstructed, leading to abnormalities in blood supply to the heart. This study aimed to identify new ACS diagnostic biomarkers using a proteomic approach, showing potential for increasing the accuracy of ACS diagnosis. By analyzing proteins in ACS patients and healthy controls, specific biomarkers such as hemopexin and vitronectin were found to be upregulated, while fibronectin was downregulated.
Article
Biochemistry & Molecular Biology
Nicoletta Di Giorgi, Antonella Cecchettini, Elena Michelucci, Giovanni Signore, Elisa Ceccherini, Francesco Ferro, Elena Elefante, Chiara Tani, Chiara Baldini, Silvia Rocchiccioli
Summary: In this study, mass spectrometry was used to analyze the salivary proteomics of patients with established primary Sjogren's syndrome (pSS) and patients with pre-clinical SS. A common protein signature was identified in their salivary fluid. Differential expression of inflammatory, immunity-related, and acinar proteins suggests that saliva may reflect exocrine gland inflammation in the early phases of the disease. Salivary proteomics can be a valuable tool for identifying reliable biomarkers for SS, even in the preclinical phase of the disease.
Article
Immunology
Sarah Kamounah, Maria Lynn Sembler-Moller, Claus Henrik Nielsen, Anne Marie Lynge Pedersen
Summary: Sjogren's syndrome is a systemic autoimmune disease that affects the exocrine glands and causes symptoms of oral and ocular dryness. The cause of the disease is unknown and there are no distinctive clinical features. The current diagnostic methods are complex and invasive, so there is a need for non-invasive immunological and molecular biomarkers to simplify the diagnostic process and assist in monitoring the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yubin Long, Yiran Li, Tao Wang, Andrew Ni, Jialiang Guo, Qi Dong, Shuo Yang, Junfei Guo, Ling Wang, Zhiyong Hou
Summary: This study provides the first characterization of fracture blister fluid using proteomics and compares its expression profile to cupping and burn blisters. The results show that fracture blisters have significantly higher levels of 50 proteins compared to cupping and 26 proteins compared to burn blisters. Additionally, principal component analysis reveals that fracture blisters closely resemble the protein expression profile of burn blisters but are distinct from the protein expression profile of cupping blisters. This study provides valuable insights for further analysis of the difference between blisters caused by fractures and those caused by other pathogenic factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Nazli Durmaz Celik, Ebru Erzurumluoglu, Serkan Ozben, Ugur Toprak, Goeknur Yorulmaz, Sevilhan Artan, Serhat Ozkan
Summary: Here we report a rare case of a patient with Gordon Holmes syndrome (GHS) who presented with hypogonadotropic hypogonadism, cognitive decline, and cerebellar ataxia. A novel homozygous frameshift mutation in the RNF216 gene was identified in this patient. The characteristics of this case corresponded to those of GHS; however, the specific genotype-phenotype correlations of this syndrome are still limited.
BMC MEDICAL GENOMICS
(2023)
Article
Chemistry, Analytical
Qinghua Yan, Shijiang Ma, Wenbin Nan, Hongli Chen, Qiqing Zhang
Summary: Sijunzi decoction, a classic prescription in traditional Chinese medicine, was found to restore damaged liver tissue and enzymatic activities, mainly regulating metabolic processes and being closely related to bile secretion, pyruvate metabolism, cysteine and methionine metabolism, and fatty acid metabolism pathways in the intervention of spleen deficiency syndrome. Prominent proteins like H2afx, ISG15, and STAT1 were predicted to play important roles in the action networks of Sijunzi decoction. This study offers novel perspectives for understanding the therapeutic mechanisms of Sijunzi decoction on spleen deficiency syndrome.
MICROCHEMICAL JOURNAL
(2021)
Article
Peripheral Vascular Disease
Mitsuhiro Nishimoto, Hiroshi Ohtsu, Takeshi Marumo, Wakako Kawarazaki, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Shigeru Shibata, Miki Nagase, Masashi Isshiki, Shigeyoshi Oba, Tatsuo Shimosawa, Toshiro Fujita
HYPERTENSION RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Kazuhiro Sakai, Osamu Yamazaki, Kenichi Ishizawa, Yoshifuru Tamura, Qin Wang, Masaki Ueno, Yuto Hayama, Yoshihide Fujigaki, Shigeru Shibata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Pharmacology & Pharmacy
Takuji Hosoya, Shunya Uchida, Shigeru Shibata, Naoko H. Tomioka, Makoto Hosoyamada
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chikayuki Morimoto, Yoshifuru Tamura, Shinichiro Asakawa, Emiko Kuribayashi-Okuma, Yoshikazu Nemoto, Jinping Li, Takayo Murase, Takashi Nakamura, Makoto Hosoyamada, Shunya Uchida, Shigeru Shibata
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2020)
Article
Biochemistry & Molecular Biology
Takahiro Kikuyama, Takao Susa, Mimi Tamamori-Adachi, Masayoshi Iizuka, Miho Akimoto, Hiroko Okinaga, Yoshihide Fujigaki, Shunya Uchida, Shigeru Shibata, Tomoki Okazaki
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Review
Peripheral Vascular Disease
Shigeru Shibata, Hisatomi Arima, Kei Asayama, Satoshi Hoshide, Atsuhiro Ichihara, Toshihiko Ishimitsu, Kazuomi Kario, Takuya Kishi, Masaki Mogi, Akira Nishiyama, Mitsuru Ohishi, Takayoshi Ohkubo, Kouichi Tamura, Masami Tanaka, Eiichiro Yamamoto, Koichi Yamamoto, Hiroshi Itoh
HYPERTENSION RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Osamu Yamazaki, Daigoro Hirohama, Kenichi Ishizawa, Shigeru Shibata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Daigoro Hirohama, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Hiroki Omizo, Yoshifuru Tamura, Chikayuki Morimoto, Masaki Ueno, Yuto Hayama, Emiko Kuribayashi-Okuma, Shunya Uchida, Shigeru Shibata
SCIENTIFIC REPORTS
(2020)
Article
Biology
Qin Wang, Kenichi Ishizawa, Jinping Li, Wataru Fujii, Yoshikazu Nemoto, Osamu Yamazaki, Yoshifuru Tamura, Yutaka Miura, Xuedan Nie, Ryo Abe, Hiroko Segawa, Makoto Kuro-O, Shigeru Shibata
COMMUNICATIONS BIOLOGY
(2020)
Review
Medicine, General & Internal
Kohei Odajima, Ryo Togashi, Yoshikazu Nemoto, Yuto Hayama, Shinichiro Asakawa, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Makoto Mochizuki, Ryuji Ohashi, Shigeru Shibata, Yoshihide Fujigaki
Summary: The article discusses a case of acute pyelonephritis leading to acute kidney injury, describing its clinical presentation, pathological features, and treatment process. The idea that NSAID use may be a potential risk factor is proposed.
Article
Peripheral Vascular Disease
Daigoro Hirohama, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Wakako Kawarazaki, Wataru Fujii, Shigeyoshi Oba, Shigeru Shibata, Takeshi Marumo, Toshiro Fujita
Summary: The study revealed that the activation of the Rac1-MR pathway contributes to the progression of DKD by causing hypertension and podocyte injury, highlighting MR antagonism and Rac1 inhibition as a novel strategy for DKD treatment.
Article
Peripheral Vascular Disease
Fumika Ochiai-Homma, Emiko Kuribayashi-Okuma, Yuya Tsurutani, Kenichi Ishizawa, Wataru Fujii, Kohei Odajima, Mika Kawagoe, Yoshihiro Tomomitsu, Masataka Murakawa, Shinichiro Asakawa, Daigoro Hirohama, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Yoshihide Fujigaki, Tetsuo Nishikawa, Shigeru Shibata
Summary: The study demonstrates the correlation between pendrin levels in uEVs and human PA, suggesting that therapeutic interventions can attenuate pendrin abundance in patients with PA. The analysis of pendrin in uEVs, along with other proteins, may be useful in understanding the pathophysiology of hypertensive disorders.
HYPERTENSION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Wataru Fujii, Shigeru Shibata
Summary: This article reviews the extensive research conducted over the past 80 years on the regulation and action of the mineralocorticoid receptor (MR). It highlights the role of MR and the steroid hormone aldosterone in integrating responses of tubular cells and maintaining fluid homeostasis, as well as their dysregulation in kidney diseases. Experimental studies have shown the pathological consequences of MR overactivity and the mechanisms of enhanced MR signaling, while clinical studies have demonstrated the renoprotective effects of MR blockade. The article also discusses future areas of investigation, including the use of non-steroidal MR antagonists in non-diabetic kidney disease patients and the search for downstream mediators of renoprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Kazuhiro Sakai, Hiroki Omizo, Ryo Togashi, Yuto Hayama, Masaki Ueno, Yoshihiro Tomomitsu, Yoshikazu Nemoto, Shinichiro Asakawa, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Shunya Uchida, Shigeru Shibata, Yoshihide Fujigaki
RENAL REPLACEMENT THERAPY
(2020)