Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

115OAfatinib in EGFR TKI-naïve patients (pts) with locally advanced/metastatic NSCLC harbouring EGFR mutations: An interim analysis of a phase IIIB trial

(2019) A Passaro et al.   ANNALS OF ONCOLOGY

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

(2019) Raghupathy Vengoji et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

(2018) Rama Krishna Nimmakayala et al.   GASTROENTEROLOGY

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

(2017) Saswati Karmakar et al.   Oncotarget

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

(2017) Muzafar A. Macha et al.   Oncotarget

Successful treatment with afatinib for pancreatic metastasis of lung adenocarcinoma: a case report

(2017) Tatsuo Furuya et al.   Journal of Thoracic Disease

Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

(2016) Linda S. Steelman et al.   CURRENT PHARMACEUTICAL DESIGN

Next-Generation Covalent Irreversible Kinase Inhibitors in NSCLC: Focus on Afatinib

(2015) Vera Hirsh   BIODRUGS

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling

(2015) H. Jiang et al.   MOLECULAR CANCER RESEARCH

Pancreatic cancer: from state-of-the-art treatments to promising novel therapies

(2015) Ignacio Garrido-Laguna et al.   Nature Reviews Clinical Oncology

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

(2015) Parthasarathy Seshacharyulu et al.   Oncotarget

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

(2015) Alice Nomura et al.   Oncotarget

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

(2015) Paul A. Clark et al.   NEOPLASIA

Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer

(2014) J. A. Engle et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells

(2014) A P Vaz et al.   BRITISH JOURNAL OF CANCER

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

(2014) Qiang Ding et al.   Molecular Cancer

A comprehensive review of the preclinical efficacy profile of the ErbB family blocker afatinib in cancer

(2014) Helmout Modjtahedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma

(2014) KAI CHEN et al.   ONCOLOGY REPORTS

IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells

(2014) Ying Yang et al.   PLoS One

MicroRNA-7 Inhibits Tumor Metastasis and Reverses Epithelial-Mesenchymal Transition through AKT/ERK1/2 Inactivation by Targeting EGFR in Epithelial Ovarian Cancer

(2014) Xingchen Zhou et al.   PLoS One

Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics

(2014) Cristiana Pistol Tanase   WORLD JOURNAL OF GASTROENTEROLOGY

SnapShot: Pancreatic Cancer

(2013) Haiyong Han et al.   CANCER CELL

SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms

(2013) Stuti Shroff et al.   HUMAN PATHOLOGY

Pathobiological Implications of MUC4 in Non–Small-Cell Lung Cancer

(2013) Prabin Dhangada Majhi et al.   Journal of Thoracic Oncology

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells

(2013) Partha Mukhopadhyay et al.   PLoS One

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy

(2013) María P. Torres et al.   PLoS One

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

Detection and Clinical Significance of CD44v6 and Integrin-β1 in Pancreatic Cancer Patients using a Triplex Real-Time RT-PCR Assay

(2012) Gang Zhou et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine

(2012) Anke Van den broeck et al.   BMC CANCER

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Pancreatic cancer stem cells: Emerging target for designing novel therapy

(2012) Yiwei Li et al.   CANCER LETTERS

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

EGFR Kinase Promotes Acquisition of Stem Cell-Like Properties: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma Stem Cells

(2012) Eric L. Abhold et al.   PLoS One

Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells

(2011) N Ioannou et al.   BRITISH JOURNAL OF CANCER

An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer

(2011) S. Ling et al.   CANCER RESEARCH

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE