Review
Biochemistry & Molecular Biology
Zhen Zeng, Minyang Fu, Yuan Hu, Yuquan Wei, Xiawei Wei, Min Luo
Summary: This article reviews the origin, biological characteristics, and regulatory networks of cancer stem cells (CSCs), discusses the factors influencing therapy resistance in CSCs, and introduces some treatment strategies specifically targeting CSCs.
Review
Oncology
Fangfang Zhuo, Shuang Luo, Wei He, Zhanhui Feng, Ya'nan Hu, Jingxia Xu, Zejun Wang, Jianwei Xu
Summary: Signaling pathways, including phosphoinositide 3-kinase (PI3K)/AKT, nuclear factor-kappa B, Ras, interleukin (IL)-17B/IL-17RB, Wnt, and hepatocyte growth factor/c-MET, play important roles in the occurrence, development, and treatment of pancreatic cancer (PC). Chemotherapy is the main treatment method, but drug resistance is a major limitation. Abnormal activation of IL-17B/IL-17RB signaling pathway is associated with drug resistance. This article discusses the different roles of signaling pathways in PC and current research on their treatment.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Review
Cell Biology
Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez, Karla Vazquez-Santillan
Summary: Breast cancer stem cells (BCSCs) are a specific subpopulation of cells capable of self-renewal and differentiation into diverse tumor cells. The involvement of cancer stem cells in treatment resistance and cancer recurrence is well established. Specific signaling pathways, such as Wnt/beta-catenin, NF-kappa B, Notch, Hedgehog, TGF-beta, and Hippo, play crucial roles in regulating the self-renewal ability of cancer stem cells. Targeting these signaling pathways holds promise as a therapeutic strategy for combating breast cancer aggressiveness. This review discusses the main signaling pathways involved in maintaining the self-renewal ability of BCSCs and highlights current strategies to disrupt stemness-related signaling molecules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Bashdar Mahmud Hussen, Abbas Salihi, Sara Tharwat Abdullah, Mohammed Fatih Rasul, Hazha Jamal Hidayat, Mohammadreza Hajiesmaeili, Soudeh Ghafouri-Fard
Summary: This article investigates the mechanisms of miRNA regulation in tumor angiogenesis and highlights the applications of anti-angiogenic therapy and miRNA delivery methods in inhibiting angiogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Cell & Tissue Engineering
Kai Song, Maryam Farzaneh
Summary: Breast cancer stem cells play a critical role in the metastasis and aggressiveness of breast cancer, making them a suitable target for treatment. Signaling pathways such as Wnt, NF kappa B, and miRNAs are key players in regulating BCSC self-renewal and metastasis. Targeting these pathways may offer a novel therapeutic approach for breast cancer diagnosis and therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pathology
Ahmed S. Doghish, Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Elsayed G. E. Elsakka, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Ahmed Amr Raouf, Mohammed S. Elballal, Walaa A. El-Dakroury, Mohamed M. M. AbdelRazek, Mina Noshy, Hussein M. El-Husseiny, Ahmed I. Abulsoud
Summary: Esophageal cancer is a major cause of cancer-related deaths worldwide, and miRNAs play a crucial role in its pathogenesis and response to treatment. Dysregulation of miRNA expression is associated with various aspects of esophageal cancer, including initiation, progression, evasion of apoptosis, invasion, and epithelial-mesenchymal transition. Key pathways in esophageal cancer, such as Wnt/-catenin signaling, mTOR/P-gp, PI3K/AKT/c-Myc, EGFR, and TGF-β signaling, are modulated by miRNAs. This review provides an updated assessment of the role of miRNAs in esophageal cancer and their potential as therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Botle Precious Setlai, Rodney Hull, Meshack Bida, Chrisna Durandt, Thanyani Victor Mulaudzi, Aristotelis Chatziioannou, Zodwa Dlamini
Summary: Immune response is crucial for patient prognosis and response to cancer treatment. Tumors evade immune surveillance by altering antigen processing pathways and the tumor microenvironment. This review highlights the molecular signaling pathways involved in immune suppression and how cancer cells manipulate antigen processing to escape immune surveillance. Additionally, the review explores the potential use of these pathways in precision medicine and understanding drug resistance.
Article
Cell Biology
Ava Nasrolahi, Shirin Azizidoost, Klaudia Radoszkiewicz, Sajad Najafi, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Seyed Esmaeil Khoshnam, Maryam Farzaneh, Shahab Uddin
Summary: Glioma is a common malignant brain tumor that arises from glial tissue. Glioma cancer stem cells (GCSCs) have been identified as playing important roles in tumor initiation and metastasis. Targeting GCSCs and their associated signaling pathways, as well as non-coding RNAs, could be a novel strategy for glioma treatment. In this review, critical signaling pathways involved in GCSC tumorigenesis and invasiveness are summarized.
CELLULAR SIGNALLING
(2023)
Review
Oncology
Andrew M. Hersh, Hallie Gaitsch, Safwan Alomari, Daniel Lubelski, Betty M. Tyler
Summary: Glioblastoma stem cells (GSCs) are a unique population of tumor cells that play a key role in tumor growth and treatment resistance. Dysregulation of critical signaling pathways and epigenomic changes in GSCs have been identified as potential therapeutic targets. A multi-pronged therapeutic approach targeting multiple pathways and molecules may be necessary for effective treatment. Further research on GSCs and treatment methods is crucial as the outcomes for GSCs remain poor.
Review
Medicine, Research & Experimental
Pawan Kumar Raghav, Zoya Mann
Summary: Cancer stem cells play a crucial role in tumorigenesis and present challenges for treatment. Despite multiple treatment options available, the lack of specificity and dose limitation hinders complete efficacy in controlling CSCs.
Review
Oncology
Antara Banerjee, Dikshita Deka, Makalakshmi Muralikumar, Alexander Sun-Zhang, Atil Bisgin, Cynthia Christopher, Hong Zhang, Xiao-Feng Sun, Surajit Pathak
Summary: Colon cancer remains a major cause of death, and cancer stem cells play a significant role in its progression, metastasis, and recurrence. miRNAs have become increasingly important in the context of colon cancer, and a comprehensive understanding of their regulatory roles could lead to effective treatment strategies.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jia Guo, Hanyi Zhang, Wenri Lin, Lixia Lu, Juan Su, Xiang Chen
Summary: This review article provides an overview of the epidemiology, clinical subtypes, pathophysiology, and comorbidities of psoriasis. It discusses the signaling pathways, metabolic and epigenetic mechanisms, as well as current treatment options and potential mechanisms of disease recurrence.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
Bingxin Zheng, Yixin Zheng, Ningning Zhang, Yi Zhang, Baodong Zheng
Summary: This study aimed to evaluate the anti-pancreatic cancer effects of flavonoids in Plumula Nelumbinis. Rhoifolin was found to be the most abundant component and showed the maximum inhibitory effect on cell proliferation. Rhoifolin inhibited cell migration and invasion, and increased the antioxidant capacity. The study also showed that rhoifolin regulated the AKT/JNK/caspase-3 and TGF-beta 2/SMAD2 signaling pathways.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Hannes Borchardt, Alexander Ewe, Markus Morawski, Ulrike Weirauch, Achim Aigner
Summary: The replacement of miR24-3p may be an effective strategy for pancreatic cancer therapy, leading to cell inhibition through the induction of apoptosis, autophagy, and ROS. Comprehensive analyses revealed the transcriptional regulation of several important oncogenes and oncogenic pathways by miR24-3p on the molecular level.
Article
Cell Biology
Mihaela Chivu-Economescu, Coralia Bleotu, Camelia Grancea, Daniela Chiriac, Anca Botezatu, Iulia Iancu, Ioana Pitica, Laura G. Necula, Ana Neagu, Lilia Matei, Denisa Dragu, Camelia Sultana, Elena L. Radu, Alina Nastasie, Oana Voicu, Marius Ataman, Saviana Nedeianu, Cristina Mambet, Carmen C. Diaconu, Simona Maria Ruta
Summary: SARS-CoV-2 vaccines are effective in preventing severe forms of the disease, hospitalization, and death. However, they may provide insufficient protection against certain viral variants, indicating the need for additional vaccine doses. A study found that even after 6 months of vaccination or infection, the neutralizing activity remains high, although there is a slight decrease in the level of anti-S IgG antibodies. Vaccinated individuals who had a prior infection showed the highest neutralization titres. The study also observed cellular immune responses in vaccinated participants, even in those with declining antibody levels or low neutralizing activity, although the response was lower compared to those with preserved humoral responses.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mihaela Chivu-Economescu, Laura G. Necula, Lilia Matei, Denisa Dragu, Coralia Bleotu, Andrei Sorop, Vlad Herlea, Simona Dima, Irinel Popescu, Carmen C. Diaconu
Summary: In this study, through bioinformatics assessment and gene analysis, we identified nine candidate biomarker genes associated with gastric cancer progression and prognosis. The high expression of these genes is correlated with poor overall survival and immune infiltrate, making them potential new therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Laura Necula, Lilia Matei, Denisa Dragu, Ioana Pitica, Ana Neagu, Coralia Bleotu, Carmen C. Diaconu, Mihaela Chivu-Economescu
Summary: This article provides an overview of the application of the collagen family as biomarkers in cancer therapy, and discusses their role in promoting tumor growth and creating a permissive environment for metastatic dissemination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Diana Stan, Elena Codrici, Ana-Maria Enciu, Ewa Olewnik-Kruszkowska, Georgiana Gavril, Lavinia Liliana Ruta, Carmen Moldovan, Oana Brincoveanu, Lorena-Andreea Bocancia-Mateescu, Andreea-Cristina Mirica, Dana Stan, Cristiana Tanase
Summary: Healthcare professionals face challenges in managing wounds, but hydrogel wound dressings offer an effective solution with their affordability, ease of use, and ability to enhance wound healing. Our study developed and evaluated hybrid hydrogel membranes enriched with bioactive components, demonstrating favorable properties with minimal concentrations of bioactive agents.
Article
Oncology
Mihaela Chivu-Economescu, Vlad Herlea, Simona Dima, Andrei Sorop, Catalin Pechianu, Alexandru Procop, Shuji Kitahara, Laura Necula, Lilia Matei, Denisa Dragu, Ana-Iulia Neagu, Coralia Bleotu, Carmen C. Diaconu, Irinel Popescu, Dan G. Duda
Summary: In this study, the researchers compared the expression of PD-L1 in primary tissue samples and sPD-L1 concentration in preoperative plasma samples from gastric cancer patients. They found that sPD-L1 levels were associated with tissue PD-L1 expression, greater inflammatory cell infiltration, disease progression, and poor overall survival. The study suggests that sPD-L1 may serve as a useful minimally invasive diagnostic and prognostic biomarker in gastric cancer patients.
Article
Oncology
Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura G. Necula, Ana I. Neagu, Lilia Matei, Ioana M. Pitica, Saviana Nedeianu, Mihaela Chivu-Economescu, Coralia Bleotu, Marius Ataman, Gabriela Mocanu, Carmen Saguna, Anca G. Pavel, Danae Stambouli, Elise Sepulchre, Gabriela Anton, Carmen C. Diaconu, Stefan N. Constantinescu
Summary: This study reports an unusual case of primary myelofibrosis (PMF) in a patient with hepatitis C virus (HCV) cirrhosis, who developed leukemia transformation in less than 1 year, leading to a fatal outcome. Analysis revealed that genetic events in the RAS signaling pathway may have contributed to the development of the leukemia clone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Simona Isabelle Stoica, Gelu Onose, Ioana Madalina Pitica, Ana Iulia Neagu, Gabriela Ion, Lilia Matei, Laura Denisa Dragu, Lacramioara-Elena Radu, Mihaela Chivu-Economescu, Laura Georgiana Necula, Aurelian Anghelescu, Carmen Cristina Diaconu, Constantin Munteanu, Coralia Bleotu
Summary: This study evaluated cellular and molecular changes in chronic ethanol-consuming patients with a model mimicking spinal cord injury. The results showed that long-term ethanol exposure had a cytotoxic effect and induced apoptosis. However, under hypoxic stress, ethanol-exposed cells displayed reduced ROS levels and increased HIF-1 alpha protein levels, indicating an adaptation to stressful conditions.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Polymer Science
Petruta Preda, Ana-Maria Enciu, Cristiana Tanase, Maria Dudau, Lucian Albulescu, Monica-Elisabeta Maxim, Raluca Nicoleta Darie-Nita, Oana Brincoveanu, Marioara Avram
Summary: This study aimed to investigate and develop amorphous and crosslinked hydrogels based on natural compounds, such as sodium alginate, aloe vera gel powder, and chitosan, for tumor spheroid formation. The results showed that adding chitosan allowed the formation of spheroids at pH 5, while low viscosity and pH 12 aloe vera gels also promoted spheroid formation. Crosslinked hydrogel variants enhanced spheroid formation efficiency.
Meeting Abstract
Oncology
C. Tanase, E. Codrici, I. D. S. Popescu, A-M. Enciu, L. Albulescu, M. Dudau, M-L. Popa, R. Albulescu
ANNALS OF ONCOLOGY
(2022)
Review
Medicine, General & Internal
Iuliana Iordan, Minodora Onisai, Ana-Maria Vladareanu, Cristina Mambet, Elena Cristina Marinescu, Raluca Nistor, Horia Bumbea
Summary: ATL is a rare but highly aggressive T-cell neoplasm associated with HTLV-1 infection, characterized by a range of neurological symptoms. This review emphasizes the importance of a multidisciplinary approach in managing the neurological symptoms of ATL patients.
MEDICINA-LITHUANIA
(2022)
Article
Polymer Science
Petruta Preda, Ana-Maria Enciu, Bianca Adiaconita, Iuliana Mihalache, Gabriel Craciun, Adina Boldeiu, Ludmila Aricov, Cosmin Romanitan, Diana Stan, Catalin Marculescu, Cristiana Tanase, Marioara Avram
Summary: This study developed a new formulation of amorphous hydrogel and demonstrated its pro-proliferation and antibacterial properties. These hydrogels show potential as alternatives for wound healing.
Meeting Abstract
Biochemistry & Molecular Biology
I. D. Popescu, E. Codrici, A. M. Enciu, S. Pop, M. C. Pristavu, A. Moraru, C. Tanase
Meeting Abstract
Biochemistry & Molecular Biology
E. Codrici, A. M. Enciu, I. D. Popescu, L. Albulescu, C. Tanase
Meeting Abstract
Biochemistry & Molecular Biology
A. Enciu, P. Preda, E. Codrici, D. I. Popescu, N. Constantin, T. Burinaru, B. Tincu, C. Tanase, M. Avram
