Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
出版年份 2019 全文链接
标题
Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
作者
关键词
Temozolomide, Afatinib, Glioblastoma, Cancer stem cells, Epidermal growth factor receptor
出版物
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-06-18
DOI
10.1186/s13046-019-1264-2
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Crizotinib and erlotinib inhibits growth of c-Met + /EGFRvIII + primary human glioblastoma xenografts
- (2018) C. Rory Goodwin et al. CLINICAL NEUROLOGY AND NEUROSURGERY
- Effects of Aptamer to U87-EGFRvIII Cells on the Proliferation, Radiosensitivity, and Radiotherapy of Glioblastoma Cells
- (2018) Xingmei Zhang et al. Molecular Therapy-Nucleic Acids
- hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells
- (2017) Saswati Karmakar et al. Oncotarget
- Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells
- (2017) Muzafar A. Macha et al. Oncotarget
- GADD45A plays a protective role against temozolomide treatment in glioblastoma cells
- (2017) Hsiao-Han Wang et al. Scientific Reports
- Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
- (2017) Jessica E. C. Jones et al. PLoS One
- Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice
- (2016) Shi-rong Zhang et al. ACTA PHARMACOLOGICA SINICA
- First-Line Afatinib versus Chemotherapy in Patients with Non–Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases
- (2016) Martin Schuler et al. Journal of Thoracic Oncology
- Mechanisms regulating glioma invasion
- (2015) Ivy Paw et al. CANCER LETTERS
- Efficacy of the Irreversible ErbB Family Blocker Afatinib in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI)–Pretreated Non–Small-Cell Lung Cancer Patients with Brain Metastases or Leptomeningeal Disease
- (2015) Petra Hoffknecht et al. Journal of Thoracic Oncology
- Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial
- (2015) Jean-Charles Soria et al. LANCET ONCOLOGY
- CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012
- (2015) Quinn T. Ostrom et al. NEURO-ONCOLOGY
- Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: A case report
- (2015) Jad Alshami et al. Oncotarget
- Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells
- (2015) Sachi Horibata et al. Jove-Journal of Visualized Experiments
- The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases
- (2015) Vinochani Pillay et al. NEOPLASIA
- Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition
- (2015) Paul A. Clark et al. NEOPLASIA
- HER2 aberrations in cancer: Implications for therapy
- (2014) Min Yan et al. CANCER TREATMENT REVIEWS
- Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
- (2014) Floris H. Groenendijk et al. INTERNATIONAL JOURNAL OF CANCER
- Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial
- (2014) Yi-Long Wu et al. LANCET ONCOLOGY
- Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase
- (2014) Ross Carruthers et al. Molecular Oncology
- JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma
- (2014) Q. Zheng et al. NEURO-ONCOLOGY
- MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway
- (2014) M A Macha et al. ONCOGENE
- EGFR and c-Met Cross Talk in Glioblastoma and Its Regulation by Human Cord Blood Stem Cells
- (2014) Kiran Kumar Velpula et al. Translational Oncology
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1
- (2014) Eun-Jung Kim et al. TUMOR BIOLOGY
- Differentiation of glioblastoma multiforme stem-like cells leads to downregulation of EGFR and EGFRvIII and decreased tumorigenic and stem-like cell potential
- (2013) Marie-Thérése Stockhausen et al. CANCER BIOLOGY & THERAPY
- Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling
- (2013) Muzafar A. Macha et al. CANCER LETTERS
- Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III
- (2013) D. R. Emlet et al. CANCER RESEARCH
- Afatinib: First Global Approval
- (2013) Rosselle T. Dungo et al. DRUGS
- Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma
- (2013) Lei Ma et al. FEBS Journal
- Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
- (2013) Mark R. Gilbert et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma WithEGFRMutations
- (2013) Lecia V. Sequist et al. JOURNAL OF CLINICAL ONCOLOGY
- MET Signaling Regulates Glioblastoma Stem Cells
- (2012) K. M. Joo et al. CANCER RESEARCH
- JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation
- (2012) Daijiro Harada et al. CANCER SCIENCE
- Standards of care for treatment of recurrent glioblastoma—are we there yet?
- (2012) Michael Weller et al. NEURO-ONCOLOGY
- CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib
- (2011) Daniel B. Costa et al. JOURNAL OF CLINICAL ONCOLOGY
- Glioblastoma survival in the United States before and during the temozolomide era
- (2011) Derek R. Johnson et al. JOURNAL OF NEURO-ONCOLOGY
- FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion
- (2011) Therese B. Deramaudt et al. MOLECULAR BIOLOGY OF THE CELL
- MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells
- (2011) I Lakshmanan et al. ONCOGENE
- c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
- (2011) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting the Dimerization of Epidermal Growth Factor Receptors with Small-Molecule Inhibitors
- (2010) Robert Y. C. Yang et al. Chemical Biology & Drug Design
- Minimally Cytotoxic Doses of Temozolomide Produce Radiosensitization in Human Glioblastoma Cells Regardless of MGMT Expression
- (2010) M. S. Bobola et al. MOLECULAR CANCER THERAPEUTICS
- EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
- (2009) B. Lal et al. MOLECULAR CANCER THERAPEUTICS
- Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators
- (2008) H.-W. Lo et al. CLINICAL CANCER RESEARCH
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
- (2008) D Li et al. ONCOGENE
- HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
- (2008) H Korkaya et al. ONCOGENE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now