The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
出版年份 2021 全文链接
标题
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-18
DOI
10.1038/s41573-020-00093-1
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics
- (2020) Tanya R. McKitrick et al. BIOCHEMISTRY
- Translational immune correlates of indirect antibody immunization in a randomized phase II study using scheduled combination therapy with carboplatin/paclitaxel plus oregovomab in ovarian cancer patients
- (2020) Alessandra Battaglia et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Front-line chemo-immunotherapy with carboplatin-paclitaxel using oregovomab indirect immunization in advanced ovarian cancer: A randomized phase II study
- (2020) Molly Brewer et al. GYNECOLOGIC ONCOLOGY
- On‐Chip Neo‐Glycopeptide Synthesis for Multivalent Glycan Presentation
- (2020) Marco Mende et al. CHEMISTRY-A EUROPEAN JOURNAL
- Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
- (2020) Valerie Barbier et al. Nature Communications
- Optimal Dissociation Methods Differ for N- and O-Glycopeptides
- (2020) Nicholas M. Riley et al. JOURNAL OF PROTEOME RESEARCH
- Targeted glycan degradation potentiates the anticancer immune response in vivo
- (2020) Melissa A. Gray et al. Nature Chemical Biology
- Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
- (2020) Evan S. Dellon et al. NEW ENGLAND JOURNAL OF MEDICINE
- A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
- (2020) Emily Rodrigues et al. Nature Communications
- Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS)
- (2019) Franck Morschhauser et al. Lancet Haematology
- Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing
- (2019) Satoshi Uchiyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
- (2019) Stacy A. Malaker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
- (2019) Jun Wang et al. NATURE MEDICINE
- CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen
- (2019) Shiteng Duan et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of CD33 Variants on Neuroimaging Biomarkers in Non-Demented Elders
- (2019) Ya-Juan Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
- (2019) John V. Pluvinage et al. NATURE
- Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis
- (2019) Mark Esposito et al. NATURE CELL BIOLOGY
- Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment
- (2019) Quentin Haas et al. Cancer Immunology Research
- Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy
- (2019) Heng-Huan Lee et al. CANCER CELL
- An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
- (2019) Yoshiki Narimatsu et al. MOLECULAR CELL
- CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
- (2019) Amira A. Barkal et al. NATURE
- TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
- (2019) Ana Griciuc et al. NEURON
- Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
- (2019) Barbara Muz et al. Blood Cancer Journal
- High E-Selectin Ligand Expression Contributes to Chemotherapy-Resistance in Poor Risk Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML) Patients and Can be Overcome with the Addition of Uproleselan
- (2019) Daniel J. DeAngelo et al. BLOOD
- Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses
- (2019) Rie Suematsu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VISTA is an acidic pH-selective ligand for PSGL-1
- (2019) Robert J. Johnston et al. NATURE
- A novel, fully human anti-fucosyl-GM1 antibody demonstrates potent in vitro and in vivo antitumor activity in preclinical models of small cell lung cancer
- (2018) Paul Ponath et al. CLINICAL CANCER RESEARCH
- Investigational CD33-targeted therapeutics for acute myeloid leukemia
- (2018) Roland B. Walter EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells
- (2018) Nandini Mondal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Galectins at a glance
- (2018) Ludger Johannes et al. JOURNAL OF CELL SCIENCE
- Next generation of immune checkpoint therapy in cancer: new developments and challenges
- (2018) Julian A. Marin-Acevedo et al. Journal of Hematology & Oncology
- Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
- (2018) Christopher W. Mount et al. NATURE MEDICINE
- Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection
- (2018) Vasilios Kalas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical Trials and Applications of Galectin Antagonists
- (2018) Armand Girard et al. TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
- Cell-based glycan arrays for probing glycan–glycan binding protein interactions
- (2018) Jennie Grace Briard et al. Nature Communications
- Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers
- (2018) Xiaodong Sun et al. BMC CANCER
- Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
- (2018) Michal A. Stanczak et al. JOURNAL OF CLINICAL INVESTIGATION
- Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells
- (2018) Jerry J. Fong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis
- (2018) Abdullah Kutlar et al. AMERICAN JOURNAL OF HEMATOLOGY
- A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia
- (2018) David R. Spiciarich et al. CANCER RESEARCH
- Leveraging Bioorthogonal Click Chemistry to Improve 225Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma
- (2018) Sophie Poty et al. CLINICAL CANCER RESEARCH
- Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?
- (2018) Francesco Panza et al. Immunotherapy
- Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties
- (2017) Huifeng Yu et al. GLYCOBIOLOGY
- Targeting the PSGL-1 pathway for immune modulation
- (2017) Roberto Tinoco et al. Immunotherapy
- Extrinsic sialylation is dynamically regulated by systemic triggersin vivo
- (2017) Charles T. Manhardt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Siglec Ligands Using a Proximity Labeling Method
- (2017) Lanyi Chang et al. JOURNAL OF PROTEOME RESEARCH
- Development of IsoTaG, a Chemical Glycoproteomics Technique for Profiling Intact N- and O-Glycopeptides from Whole Cell Proteomes
- (2017) Christina M. Woo et al. JOURNAL OF PROTEOME RESEARCH
- Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-α2b in patients with metastatic melanoma
- (2017) Ahmad A. Tarhini et al. MELANOMA RESEARCH
- CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
- (2017) Terry J Fry et al. NATURE MEDICINE
- Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
- (2017) Kenneth I. Ataga et al. NEW ENGLAND JOURNAL OF MEDICINE
- Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils
- (2017) Camilla Engblom et al. SCIENCE
- Molecular basis of human CD22 function and therapeutic targeting
- (2017) June Ereño-Orbea et al. Nature Communications
- Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects
- (2017) Laura F. Hutchins et al. Oncotarget
- Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines
- (2016) Danyang Feng et al. ACS Chemical Biology
- Dinutuximab
- (2016) Cady Ploessl et al. ANNALS OF PHARMACOTHERAPY
- Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion
- (2016) Marilyn J. Telen et al. BRITISH JOURNAL OF HAEMATOLOGY
- Hyaluronan: A modulator of the tumor microenvironment
- (2016) Theerawut Chanmee et al. CANCER LETTERS
- Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina
- (2016) Marcus Karlstetter et al. EMBO Molecular Medicine
- Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology
- (2016) Robert Sackstein GLYCOBIOLOGY
- Biological roles of glycans
- (2016) Ajit Varki GLYCOBIOLOGY
- Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
- (2016) Avery D. Posey et al. IMMUNITY
- Effects of P-Selectin Antagonist Inclacumab in Patients Undergoing Coronary Artery Bypass Graft Surgery
- (2016) Barbara E. Stähli et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
- (2016) Richard Beatson et al. NATURE IMMUNOLOGY
- Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia
- (2016) Hagop M. Kantarjian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Precision glycocalyx editing as a strategy for cancer immunotherapy
- (2016) Han Xiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- P-selectin is a nanotherapeutic delivery target in the tumor microenvironment
- (2016) Y. Shamay et al. Science Translational Medicine
- Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone
- (2016) Trevor T. Price et al. Science Translational Medicine
- Effects of the P‐Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention According to Timing of Infusion: Insights From the SELECT‐ACS Trial
- (2016) Barbara E. Stähli et al. Journal of the American Heart Association
- A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission
- (2016) Roisin O’Cearbhaill et al. Cancers
- Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
- (2015) M. J. Telen et al. BLOOD
- Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
- (2015) Rodger P. McEver CARDIOVASCULAR RESEARCH
- Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation
- (2015) Ismael Secundino et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
- (2015) S S Kenderian et al. LEUKEMIA
- Association of Alzheimer's disease GWAS loci with MRI markers of brain aging
- (2015) Ganesh Chauhan et al. NEUROBIOLOGY OF AGING
- A Phase I Study of the Anti-Idiotype Vaccine Racotumomab in Neuroblastoma and Other Pediatric Refractory Malignancies
- (2015) Walter Cacciavillano et al. PEDIATRIC BLOOD & CANCER
- Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer
- (2015) Jacob L. Houghton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation
- (2015) Shaun Spence et al. Science Translational Medicine
- Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo
- (2015) Venkata R. Krishnamurthy et al. Nature Communications
- The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic
- (2015) Elizabeth S. Gabitzsch et al. Oncotarget
- Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages
- (2015) Anahita Shahraz et al. Scientific Reports
- Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: Results of the ALFA-0701 trial
- (2015) Aline Renneville et al. Oncotarget
- Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice
- (2014) T. Toubai et al. BLOOD
- Immunological response induced by abagovomab as a maintenance therapy in patients with epithelial ovarian cancer: relationship with survival—a substudy of the MIMOSA trial
- (2014) Alexia Buzzonetti et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Globo-H Ceramide Shed from Cancer Cells Triggers Translin-Associated Factor X-Dependent Angiogenesis
- (2014) J.-Y. Cheng et al. CANCER RESEARCH
- Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with β-Glucan for High-Risk Neuroblastoma in Second or Later Remission
- (2014) Brian H. Kushner et al. CLINICAL CANCER RESEARCH
- A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients
- (2014) S. Alfonso et al. CLINICAL CANCER RESEARCH
- Siglec-7 is an inhibitory receptor on human mast cells and basophils
- (2014) Sa'ar Mizrahi et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Mechanism and Function of Monoclonal Antibodies Targeting Siglec-15 for Therapeutic Inhibition of Osteoclastic Bone Resorption
- (2014) Matthew Stuible et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs
- (2014) Heinz Läubli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance
- (2014) Camilla Jandus et al. JOURNAL OF CLINICAL INVESTIGATION
- Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus
- (2014) Syed Raza Ali et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
- (2014) Ted Wun et al. PLoS One
- PILR and PILR have a siglec fold and provide the basis of binding to sialic acid
- (2014) Q. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
- (2014) Heinz Läubli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR
- (2014) K. Kuroki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b 2-integrin-dependent signaling
- (2013) S. J. McMillan et al. BLOOD
- A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
- (2013) S. H. Petersdorf et al. BLOOD
- Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients
- (2013) Michael A. Morse et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
- (2013) Catharina Steentoft et al. EMBO JOURNAL
- Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis
- (2013) Matthew S. Macauley et al. JOURNAL OF CLINICAL INVESTIGATION
- Adjuvant Ganglioside GM2-KLH/QS-21 Vaccination Versus Observation After Resection of Primary Tumor > 1.5 mm in Patients With Stage II Melanoma: Results of the EORTC 18961 Randomized Phase III Trial
- (2013) Alexander M.M. Eggermont et al. JOURNAL OF CLINICAL ONCOLOGY
- Abagovomab As Maintenance Therapy in Patients With Epithelial Ovarian Cancer: A Phase III Trial of the AGO OVAR, COGI, GINECO, and GEICO—The MIMOSA Study
- (2013) Paul Sabbatini et al. JOURNAL OF CLINICAL ONCOLOGY
- CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing
- (2013) M. Malik et al. JOURNAL OF NEUROSCIENCE
- Applying PET to Broaden the Diagnostic Utility of the Clinically Validated CA19.9 Serum Biomarker for Oncology
- (2013) N. T. Viola-Villegas et al. JOURNAL OF NUCLEAR MEDICINE
- Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non–ST-Segment Elevation Myocardial Infarction
- (2013) Jean-Claude Tardif et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth
- (2013) C. Bull et al. MOLECULAR CANCER THERAPEUTICS
- Account for the 'dark matter' of biology
- (2013) Ajit Varki NATURE
- Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
- (2013) Jason E Hudak et al. Nature Chemical Biology
- T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
- (2013) Esther Bandala-Sanchez et al. NATURE IMMUNOLOGY
- CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
- (2013) Elizabeth M Bradshaw et al. NATURE NEUROSCIENCE
- Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
- (2013) Ana Griciuc et al. NEURON
- CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling
- (2013) J. Muller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of PSI‐697, a Novel P‐Selectin Inhibitor, on Platelet–Monocyte Aggregate Formation in Humans
- (2013) Alan G. Japp et al. Journal of the American Heart Association
- Survival Advantage in Patients with Metastatic Breast Cancer Receiving Endocrine Therapy plus Sialyl Tn-KLH Vaccine: Post Hoc Analysis of a Large Randomized Trial
- (2013) Nuhad K. Ibrahim et al. Journal of Cancer
- Click and Pick: Identification of Sialoside Analogues for Siglec-Based Cell Targeting
- (2012) Cory D. Rillahan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- MUC1 Vaccine for Individuals with Advanced Adenoma of the Colon: A Cancer Immunoprevention Feasibility Study
- (2012) T. Kimura et al. Cancer Prevention Research
- Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9
- (2012) K. Miyazaki et al. JOURNAL OF IMMUNOLOGY
- Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins
- (2012) Kamil Godula et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study
- (2012) Sylvie Castaigne et al. LANCET
- Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome
- (2012) Cory D Rillahan et al. Nature Chemical Biology
- Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
- (2012) Ingrid G Winkler et al. NATURE MEDICINE
- Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169
- (2012) Weihsu C. Chen et al. PLoS One
- Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD
- (2012) Henrik Watz et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- rPSGL-Ig for Improvement of Early Liver Allograft Function: A Double-Blind, Placebo-Controlled, Single-Center Phase II Study†
- (2011) R. W. Busuttil et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease
- (2011) T. Grader-Beck et al. ANNALS OF THE RHEUMATIC DISEASES
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3
- (2011) Nicolas Porquet et al. BMC CANCER
- Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity
- (2011) R. Sawada et al. CLINICAL CANCER RESEARCH
- Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
- (2011) Guo-Yun Chen et al. NATURE BIOTECHNOLOGY
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
- (2011) Adam C Naj et al. NATURE GENETICS
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
- (2011) Paul Hollingworth et al. NATURE GENETICS
- Mining the O-glycoproteome using zinc-finger nuclease–glycoengineered SimpleCell lines
- (2011) Catharina Steentoft et al. NATURE METHODS
- Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer
- (2011) D. Miles et al. ONCOLOGIST
- Efficacy of the pan-selectin antagonist Bimosiamose on ozone-induced airway inflammation in healthy subjects – A double blind, randomized, placebo-controlled, cross-over clinical trial
- (2011) Anne Kirsten et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Rolling Cell Adhesion
- (2010) Rodger P. McEver et al. Annual Review of Cell and Developmental Biology
- In vivo targeting of B-cell lymphoma with glycan ligands of CD22
- (2010) W. C. Chen et al. BLOOD
- GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
- (2010) J. Chang et al. BLOOD
- Effects of anti-adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts1,2
- (2010) Chris Cheadle et al. CLINICAL TRANSPLANTATION
- YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study1,2,3
- (2010) A. Osama Gaber et al. CLINICAL TRANSPLANTATION
- Sialylation of 3-Methylcholanthrene-Induced Fibrosarcoma Determines Antitumor Immune Responses during Immunoediting
- (2010) M. Cohen et al. JOURNAL OF IMMUNOLOGY
- CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity
- (2010) J. Jellusova et al. JOURNAL OF IMMUNOLOGY
- CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells
- (2010) M. K. O'Reilly et al. JOURNAL OF IMMUNOLOGY
- Alleviation of Neurotoxicity by Microglial Human Siglec-11
- (2010) Y. Wang et al. JOURNAL OF NEUROSCIENCE
- Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma
- (2010) Alice L. Yu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
- (2009) A. F. Carlin et al. BLOOD
- Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine
- (2009) Govind Ragupathi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling
- (2009) D. J. Song et al. JOURNAL OF IMMUNOLOGY
- From carbohydrate leads to glycomimetic drugs
- (2009) Beat Ernst et al. NATURE REVIEWS DRUG DISCOVERY
- CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses
- (2009) G.-Y. Chen et al. SCIENCE
- Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
- (2008) Lars Bertram et al. AMERICAN JOURNAL OF HUMAN GENETICS
- E-selectin receptors on human leukocytes
- (2008) L. Nimrichter et al. BLOOD
- Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc
- (2008) T. Ju et al. CANCER RESEARCH
- Oregovomab Maintenance Monoimmunotherapy Does Not Improve Outcomes in Advanced Ovarian Cancer
- (2008) Jonathan Berek et al. JOURNAL OF CLINICAL ONCOLOGY
- Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
- (2008) David Rabuka et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
- (2008) Martin A Pule et al. NATURE MEDICINE
- Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
- (2008) Robert Sackstein et al. NATURE MEDICINE
- Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement
- (2007) Hidenori Yokoi et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started