Ion channels as lipid sensors: from structures to mechanisms

Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer

(2020) Pramod Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1

(2020) Michael David Clark et al.   NATURE

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels

(2020) Anna L. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for pharmacological modulation of the TRPC6 channel

(2020) Yonghong Bai et al.   eLife

Structural basis for the modulation of pentameric ligand-gated ion channel function by lipids

(2020) Mackenzie J. Thompson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

(2019) Giray Enkavi et al.   CHEMICAL REVIEWS

Emerging Diversity in Lipid–Protein Interactions

(2019) Valentina Corradi et al.   CHEMICAL REVIEWS

Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes

(2019) Moutusi Manna et al.   Annual Review of Biophysics

Structural mechanisms of phospholipid activation of the human TPC2 channel

(2019) Ji She et al.   eLife

Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

(2019) Tim Rasmussen et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

(2019) Anna L. Duncan et al.   Annual Review of Pharmacology and Toxicology

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

(2019) Anant Gharpure et al.   NEURON

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

(2019) Camille M. Hénault et al.   Nature Chemical Biology

Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction

(2019) Charles D. Cox et al.   Cell Reports

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

(2019) Ailing Tong et al.   eLife

Structural Basis of Human KCNQ1 Modulation and Gating

(2019) Ji Sun et al.   CELL

Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

(2019) Bharat Reddy et al.   eLife

Bacterial Mechanosensors

(2018) Charles D. Cox et al.   Annual Review of Physiology

Structural Biology: Piezo Senses Tension through Curvature

(2018) Xin Liang et al.   CURRENT BIOLOGY

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

(2018) Ji She et al.   NATURE

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

(2018) Michaela Lichtenegger et al.   Nature Chemical Biology

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules

(2018) Nicolas Barbera et al.   BIOPHYSICAL JOURNAL

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

(2018) Richard M. Walsh et al.   NATURE

Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels

(2018) Ismail Ben Soussia et al.   Frontiers in Molecular Neuroscience

Triple arginine residues in the proximal C-terminus of TREK K+channels are critical for the biphasic regulation by PIP2

(2018) JooHan Woo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

(2018) Duncan Laverty et al.   NATURE

Fenestrations control resting-state block of a voltage-gated sodium channel

(2018) Tamer M. Gamal El-Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Piezo’s membrane footprint and its contribution to mechanosensitivity

(2018) Christoph A Haselwandter et al.   eLife

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Molecular structure of human KATP in complex with ATP and ADP

(2017) Kenneth Pak Kin Lee et al.   eLife

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations

(2016) George Hedger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids

(2016) Sun-Joo Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

(2016) Navid Bavi et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2

(2015) Stephen G. Brohawn   Annals of the New York Academy of Sciences

Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels

(2015) Francisco J. Barrantes   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function

(2015) John E. Baenziger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

(2015) Marco Cecchini et al.   NEUROPHARMACOLOGY

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Intramembrane Aromatic Interactions Influence the Lipid Sensitivities of Pentameric Ligand-gated Ion Channels

(2014) Casey L. Carswell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

(2014) Yannick Comoglio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidic acid modulation of Kv channel voltage sensor function

(2014) Richard K Hite et al.   eLife

Cholesterol binding to ion channels

(2014) Irena Levitan et al.   Frontiers in Physiology

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors

(2013) Corrie J B daCosta et al.   Nature Chemical Biology

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening

(2013) M. A. Zaydman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Dual-Mode Phospholipid Regulation of Human Inward Rectifying Potassium Channels

(2011) Wayland W.L. Cheng et al.   BIOPHYSICAL JOURNAL

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Electron spin resonance in membrane research: protein–lipid interactions from challenging beginnings to state of the art

(2009) Derek Marsh   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

A Lipid-dependent Uncoupled Conformation of the Acetylcholine Receptor

(2009) Corrie J. B. daCosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anionic Lipids Allosterically Modulate Multiple Nicotinic Acetylcholine Receptor Conformational Equilibria

(2009) Corrie J. B. daCosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE