Article
Biochemistry & Molecular Biology
Carina A. Valenzuela, Ella J. Baker, Camila O. De Souza, Elizabeth A. Miles, Philip C. Calder
Summary: Endothelial dysfunction and inflammation are key factors in atherosclerosis development. This study compared the effects of industrial and ruminant trans fatty acids on endothelial cells, finding that ruminant TFAs like TVA have anti-inflammatory properties while industrial TFAs like EA enhance inflammatory responses.
Article
Biochemistry & Molecular Biology
Arun Kumar Selvam, Rim Jawad, Roberto Gramignoli, Adnane Achour, Hugh Salter, Mikael Bjornstedt
Summary: The study evaluated a novel therapeutic regimen using MSC treatment and KYAT1 induction, which showed increased cytotoxicity in HCC cells. The use of miR122 to limit off-target effects and the addition of alpha-ketoacid to enhance cytotoxic efficacy in HCC cells demonstrate great potential to target hepatic tumors specifically.
Article
Cell Biology
Jia Ma, Jing Huang, Jinli Sun, Yanfeng Zhou, Xiaoyuan Ji, Daoxia Guo, Chang Liu, Jiyu Li, Jiye Zhang, Haiyun Song
Summary: The organic selenium compound SeMC showed high sensitivity in inhibiting A549 lung adenocarcinoma cells, inducing synergistic lethality when combined with chemotherapeutics. SeMC promoted lipid peroxidation and increased ROS generation in cancer cells. The in vivo efficacy of combination therapy was significantly enhanced by hydrogel-mediated drug delivery.
CELL PROLIFERATION
(2021)
Article
Food Science & Technology
Ting Hu, Huafen Li, Guishen Zhao, Yanbin Guo
Summary: The study revealed that the mushroom Hypsizygus marmoreus has a strong ability to absorb and convert selenium, converting inorganic selenium forms into organic selenium forms, with Se-methylselenocysteine being the most beneficial form. This suggests that selenium-enriched Hypsizygus marmoreus is a novel selenium food source for human beings.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xianwei Yang, Menghan Wang, Ximeng Kang, Fei Mo, Peiru Si, Jia Ma, Peipei Zhang, Shaohua Zheng, Jiyu Li, Yang Wang, Qingqing Li, Jiye Zhang
Summary: Vulvar candidiasis (VVC) is a common and harmful infection in women caused by Candida species. This study focused on the potential of L-Se-methylselenocysteine (L-SeMC) and a mucoadhesive thermogel (NAC-HA thermogel) for the treatment of VVC. The L-SeMC@NAC-HA thermogel showed sustained release and prolonged retention time in vitro, as well as demonstrated good safety and significant anti-VVC effects in vivo. These findings suggest that this thermogel could be a promising therapy for the clinical treatment of VVC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Jing Lu, Ziheng Chen, Xiujuan Bu, Shanshan Chen, Shuang Guan
Summary: This study found that exposure to Elaidic acid (EA) caused liver damage and hepatocyte pyroptosis through the autophagy-CTSB-NLRP3 inflammasome pathway. These findings provide new insights into the toxicity mechanism of EA.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Molly Muleya, Scott D. Young, Saul Vazquez Reina, Ivy S. Ligowe, Martin R. Broadley, Edward J. M. Joy, Prosper Chopera, Elizabeth H. Bailey
Summary: The study revealed that fertiliser-derived selenium accounted for the majority of selenium in the edible portions of crops, and both fertiliser-derived selenium and soil-derived selenium were transformed into similar organic species, with selenomethionine being the main form of fertiliser-derived selenium. Despite variations in selenium species among different crops, the bioaccessibility of fertiliser-derived selenium showed almost no difference.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Xiubo Du, Qingqing Shi, Yuxi Zhao, Yongli Xie, Xuexia Li, Qiong Liu, Javed Iqbal, Huajie Zhang, Xukun Liu, Liming Shen
Summary: The study found that Se-methylselenocysteine (SMC) can reverse the pathological phenomena of metabolic disorders, synaptic dysfunction, and oxidative stress in an Alzheimer's disease mouse model. After SMC treatment, the expression of related proteins was reversed, which may be the main mechanism of SMC intervention in AD.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Jiaxin Hu, Zhu Chen, Jing Yang, Qianhui Shi, Fuqian Jin, Qiyuan Pang, Yi Luo, Jukun Song
Summary: This study found an association between plasma elaidic acid levels and periodontal disease in American adults, with individuals having higher levels of plasma elaidic acid being more likely to have periodontitis.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Shanjie Wang, Wei Tian, Yige Liu, Guangcan Yan, Shaohong Fang, Yafeng Wang, Bo Yu
Summary: The study found that the major isomer of industrial TFAs, elaidic acid, was associated with increased long-term total mortality, while there were no significant inverse correlations with TFAs derived from ruminants. Additionally, the associations with death risk weakened with the reduction of TFAs consumption by half.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Xichen Bai, Hong Zhou, Dan Luo, Dan Chen, Jianyuan Fan, Xiaoting Shao, Jun Zhou, Wei Liu
Summary: Cyclocarya paliurus (CP) contains triterpene acids that improve glucose and lipid metabolism disorders. The main active components, including ursolic acid (UA), oleanolic acid (OA), and betulinic acid (BA), have antihyperglycemic and antihypertensive effects. The ratio of UA, OA, and BA was optimized to form a complex known as Cyclocarya paliurus triterpenoid acid (TAC). TAC was combined with Se-methylselenocysteine (MSC) to form the TAC/MSC complex, which improved insulin resistance and alleviated type 2 diabetes mellitus (T2DM) characteristics in vitro and in vivo.
Article
Engineering, Biomedical
Nicoli Dolores Goncalves Correa, Felipe Douglas Silva, Daniel Perez Vieira, Carlos Roberto Jorge Soares, Alvaro Antonio Alencar de Queiroz
Summary: Polymeric nanoparticles loaded with selenium (Se) have shown potential in cancer chemotherapy. The functionalization of polyglycerol dendrimer (DPGLy) with seleno-methyl-selenocysteine (SeMeCys) showed promising results in reducing the viability and proliferation of head and neck squamous cell carcinoma (HNSCC) cells, while exhibiting no significant toxicity against Chinese Hamster ovary cell line (CHO-K1).
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Immunology
Heping Shen, Hongyan Pei, Liping Zhai, Qiaobing Guan, Genghuan Wang
Summary: This study aimed to investigate the mechanism of salvianolic acid C (SAC) in improving cerebral ischemia injury. The results showed that SAC can suppress the polarization of microglial cells and promote tubule formation in endothelial cells to exert neuroprotection in cerebral ischemia. SAC also inhibits the expression of inflammatory factors and maintains the blood-brain barrier function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Inge Huybrechts, Fernanda Rauber, Genevieve Nicolas, Corinne Casagrande, Nathalie Kliemann, Roland Wedekind, Carine Biessy, Augustin Scalbert, Mathilde Touvier, Krasimira Aleksandrova, Paula Jakszyn, Guri Skeie, Rashmita Bajracharya, Jolanda M. A. Boer, Yan Borne, Veronique Chajes, Christina C. Dahm, Lucia Dansero, Marcela Guevara, Alicia K. Heath, Daniel B. Ibsen, Keren Papier, Verena Katzke, Cecilie Kyro, Giovanna Masala, Esther Molina-Montes, Oliver J. K. Robinson, Carmen Santiuste de Pablos, Matthias B. Schulze, Vittorio Simeon, Emily Sonestedt, Anne Tjonneland, Rosario Tumino, Yvonne T. van der Schouw, W. M. Monique Verschuren, Beatrice Vozar, Anna Winkvist, Marc J. Gunter, Carlos A. Monteiro, Christopher Millett, Renata Bertazzi Levy
Summary: This study analyzed the diet of European populations using the Nova classification system and found variations in the consumption of UPF among different countries and sociodemographic groups. The results support the accuracy of the Nova classification in characterizing the degree of food processing and validate it through correlations with circulating biomarkers.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Harshitha Madhusoodan Jathanna, Chandrayan Vaman Rao
Summary: Microbial lipids were successfully synthesized from an industrial residue using Aspergillus ochraceus. The best conditions for lipid production were determined to be a glycerol concentration of 80 g/L, a 12% (v/v) inoculum concentration, pH 6.0, and a temperature of 30 degrees C. The extracted lipids contained valuable constituents for commercial use.
WASTE AND BIOMASS VALORIZATION
(2022)